May 2009 PMID 19538307

Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms.

Jeroen Visser, Jan Rozing, Anna Sapone, Karen Lammers, Alessio Fasano

Mentions

73
Peak: 1 in Aug 2019
across 5 sources since Aug 2019

Extended reach

1,114,516
potential audience

Total likes

26,292

Video views

1,085,874

Mentions per month

Aug 2019 – Aug 2024

Where it's discussed

  • Facebook64 posts
  • News3 articles
  • Blogs3 articles
  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Discussions reflect a supportive tone, exemplified by expressions like 'You're welcome, best wishes to you,' which indicates a positive reception. The sharing of relevant links and references demonstrates moderate engagement, with words and tone signaling interest in expanding understanding rather than profound critique.

AgreementModerate agreement

Most discussions acknowledge the significance of the publication and express a generally supportive attitude toward its conclusions.

InterestModerate interest

The topics of intestinal permeability and autoimmunity appear to attract moderate interest, as participants are engaged enough to share related links and well-wishes.

EngagementModerate engagement

Comments show some level of engagement, with personal responses and sharing additional resources, indicating an active but perhaps superficial involvement.

ImpactModerate impact

The discussions suggest that the article resonates with the audience, though no deep debates or calls to action are evident, pointing to a moderate impact.

Abstract in brief

  • Autoimmune diseases like celiac disease (CD) and type 1 diabetes (T1D) involve immune systems attacking specific organs, leading to damage and loss of function.
  • CD is unique because it has a strong genetic link to HLADQ2/DQ8 and is triggered by gluten-containing grains, while the trigger for T1D’s autoimmune attack on insulin-producing cells is still unclear, though recent evidence suggests gliadin may be involved.
  • Increased intestinal permeability, or a “leaky gut,” might play a crucial role in the development of these autoimmune diseases, alongside genetic and environmental factors, by allowing harmful substances to trigger immune reactions.]

Top posts

Most liked on X and Bluesky
Jennifer Depew, RD
@deNutrients · X

@amm3209 @wapmom @AllergyKidsDoc You're welcome, best wishes to you. this link I just added for that other person may be of interest too Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms https://t.co/mTyI9Jbwf7

Aug 13, 2019 · 28,642 followers View post →

All mentions

Jennifer Depew, RD
@deNutrients · X

@amm3209 @wapmom @AllergyKidsDoc You're welcome, best wishes to you. this link I just added for that other person may be of interest too Tight Junctions, Intestinal Permeability, and Autoimmunity Celiac Disease and Type 1 Diabetes Paradigms https://t.co/mTyI9Jbwf7

Aug 13, 2019 · 28,642 followers View post →