Am J Physiol Regul Integr Comp Physiol January 2010 PMID 19889869

Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects.

Rochelle Goldsmith, Denis R Joanisse, Dympna Gallagher, Katherine Pavlovich, Elisabeth Shamoon, Rudolph L Leibel, Michael Rosenbaum

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Mentions

10
Peak: 1 in Jul 2020
across 5 sources since Jul 2020

Extended reach

9,216,413
potential audience

Total likes

154,718

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Mentions per month

Jul 2020 – May 2023

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AI synopsis

What people are saying

The overall tone reflects a recognition of the importance of skeletal muscle efficiency in energy regulation, with specific mentions of how muscle biochemical changes, such as enzyme activity, affect energy use during low-intensity activities. Phrases like 'disproportionate decline' and references to biochemical mechanisms demonstrate an engaged and thoughtful discussion, indicating these findings may influence future research and clinical strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, noting how muscle efficiency influences energy expenditure after weight changes.

InterestModerate interest

Posts show moderate curiosity about the biochemical mechanisms and implications for weight management.

EngagementModerate engagement

There is a reasonable level of depth as some posts delve into relationships between muscle biochemistry and energy expenditure, but some remain superficial.

ImpactModerate impact

Participants recognize that these findings could influence future approaches to weight control and metabolic health.

Abstract in brief

  • Maintaining a body weight 10% above or below typical for lean or obese individuals leads to changes in how efficiently muscles work and how they use fuel during low-intensity activities.
  • These changes are mainly due to alterations in skeletal muscle biochemistry, specifically a decrease in glycolytic enzyme activity (PFK) and a lower ratio of glycolytic to oxidative enzyme activity (COX) after weight loss, without affecting muscle fiber type or mitochondrial density.
  • The observed muscle biochemical changes are linked to improvements in muscle efficiency and fuel use during low-power exercise, such as cycling at low wattage, indicating that weight management can influence muscle function at a biochemical level.]

Top posts

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Nick Krontiris
@nick_krontiris · X

- Skeletal muscle work efficiency appears to be the primary determinant of the disproportionate decline in 24- hour energy expenditure following weight loss, with additional declines in resting energy expenditure Ref: https://t.co/k1L33q54Ht

Apr 6, 2023 · 1 like · 19,553 followers View post →

All mentions

Nick Krontiris
@nick_krontiris · X

- Skeletal muscle work efficiency appears to be the primary determinant of the disproportionate decline in 24- hour energy expenditure following weight loss, with additional declines in resting energy expenditure Ref: https://t.co/k1L33q54Ht

Apr 6, 2023 · 1 like · 19,553 followers View post →
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