PubHawk
JAMA January 2010 PMID 20051569

Antidepressant drug effects and depression severity: a patient-level meta-analysis.

Jay C Fournier, Robert J DeRubeis, Steven D Hollon, Sona Dimidjian, Jay D Amsterdam, Richard C Shelton, Jan Fawcett

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Mentions

178
Peak: 4 in Oct 2025
across 6 sources since Aug 2020

Extended reach

17,460
potential audience

Total likes

61

Video views

1,071

Mentions per month

Aug 2020 – Oct 2025

Where it's discussed

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AI synopsis

What people are saying

Overall, the discussions reflect a consensus that the article's findings on the limited efficacy of antidepressants in milder depression are impactful and resonate across different languages and forums, with posts citing specific data, such as 'medication benefit is very small' and showing interest with phrases like 'beautiful figure' and references to key studies, which demonstrates a deep and meaningful engagement with the research findings.

AgreementStrong agreement

Most discussions align with the article's conclusions that antidepressants show limited effects, especially in mild cases of depression.

InterestModerate interest

While there is some curiosity about the findings, many posts are more focused on confirming existing knowledge than exploring new ideas.

EngagementHigh engagement

Several discussions reference specific studies, figures, and methods, indicating a deeper engagement with the research.

ImpactHigh impact

The conversations highlight the significant influence of the publication on ongoing debates about depression treatment effectiveness.

Abstract in brief

  • This study analyzed data from randomized controlled trials to compare the effects of antidepressant medications versus placebo across different levels of depression severity.
  • Results showed that for patients with less severe depression (HDRS scores below 23), the benefit of medication over placebo was very small and possibly insignificant, while for more severely depressed patients (HDRS scores of 25 or higher), antidepressants offered a clinically meaningful advantage.
  • Overall, the effectiveness of antidepressants increases with the severity of depression, suggesting they may be less helpful for milder cases and more beneficial for patients with more severe symptoms.
Read the full abstract

Top posts

Most liked on X and Bluesky
almaleksia
@almaleksia · X

@bardulya Ссылки будут? Я начну: https://t.co/0Yf4kqcYio то что АД неэффективны при депрессии средней тяжести - это уже научный консенсус

Oct 30, 2025 · 19 likes · 1 share · 1,473 followers View post →
Walden Dos
@WaldenDos_ · X

6. Solo se ha visto que son más efectivas QUE EL PLACEBO en las depresiones graves ------------------ Fournier et al. Antidepressant Drug Effects and Depression Severity. A Patient-Level Meta-analysis. JAMA 2010; 303(1):47-53.

Jul 9, 2021 · 8 likes · 8,956 followers View post →
Hynek Cígler
@HynekCigler · X

To zní fajn. Co antidepresiva? Jejich průměrná efektivita je menší než d < 0,20. Pokud by tedy WHM fungovala stejně dobře jako antidepresiva na depresi, výzkumníci by měli méně než 25% pravděpodobnost, že se WHM bude jevit jako efektivní, spíš méně! 7/n https://t.co/OVOAOmtzHR

Oct 25, 2023 · 7 likes · 1,370 followers View post →
almaleksia
@almaleksia · X

@aurin2012 @py3456thon10255 Так почитай: https://t.co/0twMhtmsI0

Oct 30, 2025 · 6 likes · 1,473 followers View post →
GuevarraDarwin
@GuevarraDarwin · X

One of my favorite papers comparing antidepressants with placebos by Fournier et al. (2010). What a beautiful figure. Article Info: doi:10.1001/jama.2009.1943 https://t.co/pVNPgUq6vD

Aug 19, 2020 · 2 likes · 1 share · 852 followers View post →
y
@astatinfinity · X

Человек кидает ссылку на пабмед (https://t.co/jjxHEgp4CC) как доказательство того, что АД неэффективны. Теперь читаем, что об этом думают сами авторы скинутой статьи: https://t.co/nADBh3RBNM

Oct 30, 2025 · 2 likes · 34 followers View post →

All mentions

13-надцатая
@kazziava2015 · X

RT @almaleksia: @bardulya Ссылки будут? Я начну: https://t.co/0Yf4kqcYio то что АД неэффективны при депрессии средней тяжести - это уже нау…

Oct 31, 2025 · 1 share · 889 followers View post →
y
@astatinfinity · X

Человек кидает ссылку на пабмед (https://t.co/jjxHEgp4CC) как доказательство того, что АД неэффективны. Теперь читаем, что об этом думают сами авторы скинутой статьи: https://t.co/nADBh3RBNM

Oct 30, 2025 · 2 likes · 34 followers View post →
almaleksia
@almaleksia · X

@bardulya Ссылки будут? Я начну: https://t.co/0Yf4kqcYio то что АД неэффективны при депрессии средней тяжести - это уже научный консенсус

Oct 30, 2025 · 19 likes · 1 share · 1,473 followers View post →
almaleksia
@almaleksia · X

@aurin2012 @py3456thon10255 Так почитай: https://t.co/0twMhtmsI0

Oct 30, 2025 · 6 likes · 1,473 followers View post →
Hiroshi
@Jarlaxle111 · X

-https://t.co/ZSyUPwSbZd -https://t.co/iDRGi2ab8L

Jul 26, 2024 · 56 followers View post →
Hynek Cígler
@HynekCigler · X

To zní fajn. Co antidepresiva? Jejich průměrná efektivita je menší než d < 0,20. Pokud by tedy WHM fungovala stejně dobře jako antidepresiva na depresi, výzkumníci by měli méně než 25% pravděpodobnost, že se WHM bude jevit jako efektivní, spíš méně! 7/n https://t.co/OVOAOmtzHR

Oct 25, 2023 · 7 likes · 1,370 followers View post →
Paulo Santos
@pjsosantos · X

@pedromorgado @joannamoncrieff @suzypuss @PsychSleepy @bmj_latest @tony_kendrick @jonathanstea @tylerblack32 @psychunseen @BettyBlue168 @leylasanai A investigação parece indicar que somente em casos graves de depressão a medicação antidepressiva evidencia um efeito clínico superior ao do placebo (https://t.co/5YUm9F1Zyl), mas mesmo aqui existem estudos não partilham esta opinião (https://t.co/OWJsmqNARm).

Aug 6, 2022 · 119 followers View post →
Ally Rooney
@allyrooney · X

@PadbergThorsten @PloederlM @HengartnerMP https://t.co/U8GAdWr7cg Do you mean this study? If not - please add refs, thanks

Jul 22, 2022 · 417 followers View post →
Conservative Cat Lady -
@LaraKD_2020 · X

@deriamis @WillReidWeb @LieblichSam @BodhiWeaver 1. I'd ask who paid for those studies. 2. Independent reviews consistently find the effects of SSRIs on depression to be minimal. Except, perhaps, for MDD. https://t.co/Sw0wVBHPYM

Jul 22, 2022 · 576 followers View post →
Walden Dos
@WaldenDos_ · X

6. Solo se ha visto que son más efectivas QUE EL PLACEBO en las depresiones graves ------------------ Fournier et al. Antidepressant Drug Effects and Depression Severity. A Patient-Level Meta-analysis. JAMA 2010; 303(1):47-53.

Jul 9, 2021 · 8 likes · 8,956 followers View post →
MSU Clinical Psychophysiology Lab
@therealcpl_msu · X

RT @GuevarraDarwin: One of my favorite papers comparing antidepressants with placebos by Fournier et al. (2010). What a beautiful figure.…

Aug 19, 2020 · 1 share · 166 followers View post →
GuevarraDarwin
@GuevarraDarwin · X

One of my favorite papers comparing antidepressants with placebos by Fournier et al. (2010). What a beautiful figure. Article Info: doi:10.1001/jama.2009.1943 https://t.co/pVNPgUq6vD

Aug 19, 2020 · 2 likes · 1 share · 852 followers View post →