Nat Neurosci May 2010 PMID 20348917

Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats.

Paul M Johnson, Paul J Kenny

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Mentions

99
Peak: 1 in Nov 2020
across 5 sources since Nov 2020

Extended reach

13,794
potential audience

Total likes

147

Video views

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Nov 2020 – Sep 2024

Where it's discussed

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AI synopsis

What people are saying

Discussions display strong interest in how certain foods, especially processed and high-calorie items, influence neural reward pathways, supported by phrases like 'overcome by endorphin rush' and references to landmark research, which reflect an earnest attempt to connect scientific findings with personal and common experiences of overeating and food addiction.

AgreementModerate agreement

Most discussions acknowledge the study's findings on how overeating processed, high-calorie foods affects reward mechanisms, aligning with the research's implications.

InterestHigh interest

Users show high interest, referencing related studies, discussing neurobiological mechanisms, and sharing personal observations about food addiction.

EngagementModerate engagement

There is active engagement, with mentions of specific studies, scientific concepts, and recommendations to look up sources, indicating thoughtful consideration.

ImpactModerate impact

While not universally revolutionary, these discussions highlight the importance of understanding food's effects on brain reward systems, suggesting moderate impact on perspectives about diet and addiction.

Abstract in brief

  • The study shows that as rats become obese, they develop a worsening decrease in neural reward responses, similar to what is seen in drug addiction, leading to compulsive-like eating behavior resistant to negative consequences.
  • Obese rats have lower levels of dopamine D2 receptors in their striatum, a brain area involved in reward processing, which is also observed in humans with drug addiction.
  • Reducing D2 receptor levels in the brain makes rats more likely to develop addiction-like reward deficits and compulsive eating behaviors, suggesting that overconsumption of tasty food can cause neuroadaptive changes similar to those caused by drugs.

Top posts

Most liked on X and Bluesky
Iqbal Malik
@LCC_DrMalik · X

@adnanalkhouli rats eat sugar, but not to excess. They eat fat, but not to excess. But them together- ie cheesecake, and they bloat up- the satiety centre overcome by endorphin rush with cheesecake https://t.co/KwN688ZQ1D

Feb 21, 2021 · 2 likes · 2,029 followers View post →
Breakman Radio
@breakman_radio · X

@LoCarbFreshwell One of the problems I keep encountering is, with landmark studies like Dr. Paul Kenny's 2010 paper in Nature Neuroscience, they feed the rats food like "cheesecake, sausage, and bacon," and refer to it as a "high fat, high calorie diet." https://t.co/HRF1Q2kJLj

Jan 12, 2023 · 1 like · 13 followers View post →
Prince ⚓
@DiceyPrince_ · X

Type this in Google for one of such sources

Nov 27, 2020 · 6,974 followers View post →
Todd R.
@ToddRowen · X

Study: rats given healthy food, stopped when sated, no obesity. Same rats then given US junk food. Obesity soared, lost all interest in heathy food. Then study took away processed food, only healthy food. Rats barely ate it. Only touched it when starving. https://t.co/bdxbLNLsa1

May 7, 2024 · 219 followers View post →

All mentions

Todd R.
@ToddRowen · X

Study: rats given healthy food, stopped when sated, no obesity. Same rats then given US junk food. Obesity soared, lost all interest in heathy food. Then study took away processed food, only healthy food. Rats barely ate it. Only touched it when starving. https://t.co/bdxbLNLsa1

May 7, 2024 · 219 followers View post →
Breakman Radio
@breakman_radio · X

@LoCarbFreshwell One of the problems I keep encountering is, with landmark studies like Dr. Paul Kenny's 2010 paper in Nature Neuroscience, they feed the rats food like "cheesecake, sausage, and bacon," and refer to it as a "high fat, high calorie diet." https://t.co/HRF1Q2kJLj

Jan 12, 2023 · 1 like · 13 followers View post →
Iqbal Malik
@LCC_DrMalik · X

@adnanalkhouli rats eat sugar, but not to excess. They eat fat, but not to excess. But them together- ie cheesecake, and they bloat up- the satiety centre overcome by endorphin rush with cheesecake https://t.co/KwN688ZQ1D

Feb 21, 2021 · 2 likes · 2,029 followers View post →
Prince ⚓
@DiceyPrince_ · X

Type this in Google for one of such sources

Nov 27, 2020 · 6,974 followers View post →