March 2010 PMID 20374604

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.

J J J Fu, G G Hillebrand, P Raleigh, J Li, M J Marmor, V Bertucci, P E Grimes, S H Mandy, M I Perez, S H Weinkle, J R Kaczvinsky

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Mentions

Peak: 9 in Apr 2021

across 4 sources since Oct 2020

Extended reach

521,296

potential audience

Total likes

10,364

Video views

475,541

Mentions per month

Oct 2020 – Mar 2025

Where it's discussed

X / Twitter13 posts
News5 articles
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a focus on personal skincare experiences and preferences, with posts like those mentioning peptide molecules' tolerance and individual success stories. The tone and word choice highlight personal relevance rather than critical analysis, underscoring moderate interest and engagement with limited broader impact.

AgreementNeither agree nor disagree

The discussions are neutral, with some posts highlighting the potential benefits of peptides and criticizing tretinoin's strength, but without strong consensus.

InterestModerate interest

Posts show mild to moderate interest, focusing on personal experiences and comparing treatments rather than deep scientific analysis.

EngagementNeutral engagement

There is some engagement, as users mention their own skincare routines and preferences, but little evidence of in-depth discussion of the study's methodology or broader implications.

ImpactModerate impact

The overall impact appears modest, influencing personal choices more than prompting widespread changes or critical evaluations of the research.

Abstract in brief

This study compares the effectiveness of a cosmetic niacinamide-peptide product regimen to a prescription tretinoin (0.02%) treatment for reducing facial wrinkles, focusing on both efficacy and skin tolerance over 8 and 24 weeks.
Results showed that the cosmetic products significantly improved wrinkle appearance within 8 weeks, and their benefits were similar to tretinoin after 24 weeks, while being better tolerated in terms of skin irritation and barrier effects.
The findings suggest that a well-designed cosmetic regimen can offer similar wrinkle improvements to tretinoin with fewer tolerance issues, providing a viable alternative for those concerned about skin irritation.]

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All mentions

Comparing Cosmetic Niacinamide-Peptide Regimen to Tretinoin for Wrinkle Reduction

This study compares the effectiveness of a cosmetic niacinamide-peptide product regimen to a prescription tretinoin 0.02% treatment for reducing facial wrinkles, showing similar improvements with better skin tolerance…

ingck · Jun 5, 2022 475,482 views

Niacinamide's Role in Reducing Skin Pigmentation and Hyperpigmentation

This video explores how niacinamide helps reduce skin pigmentation by inhibiting melanosome transfer from melanocytes to skin cells, leading to skin lightening and reduced hyperpigmentation, as demonstrated in clinical…

Dr. Sean Skin School · Jun 23, 2023 59 views

Jai Day

@JaiDay404 · X

@amtherealangy Wrong. Some peptide molecules are small enough to reach dermis and are way better tolerated than tret. IMO Tret should only be used for people with bad acne bc it’s too strong for most. I went thru this last yr and pep is the best for me https://t.co/OwJalla5qj

Mar 1, 2025 · 77 followers View post →

ซันเล่าเรื่องผิว Sean Skin School

@DrSeanSkinSch · X

แชร์ได้ชัวร์ #อ้างอิงแล้ว

Jun 23, 2023 · 1 share · 12,952 followers View post →

tabittop

@tabittop · X

May 5, 2021 · 17 shares · 147 followers View post →

Sad

@Sad87446366 · X

Apr 9, 2021 · 17 shares View post →

Roger Smith, Chief Operating Officer

@augmentinabuser · X

Apr 8, 2021 · 17 shares · 7,804 followers View post →

ภอ อู

@DarJeelingPu · X

Apr 8, 2021 · 17 shares · 276 followers View post →

ʚїɞ

@Gunnery_girl · X

Apr 8, 2021 · 17 shares · 312 followers View post →

NerverZ JustOnly Me

@NerverZ · X

Apr 8, 2021 · 17 shares · 262 followers View post →

mingstalik

@mingstalik · X

Apr 8, 2021 · 17 shares · 485 followers View post →

หลอน

@lhorn_lhorn · X

Apr 8, 2021 · 17 shares · 7,767 followers View post →

lll ที่ใจสั่นเพราะกาแฟหรือแกฟะ

@BorntoeatBaconn · X

Apr 8, 2021 · 17 shares · 378 followers View post →

Roger Smith, Chief Operating Officer

@augmentinabuser · X

Apr 8, 2021 · 5 likes · 17 shares · 7,804 followers View post →

Kiki

@friedelcraft · X

@disease_____ https://t.co/JN3DLkScWy

Oct 22, 2020 · 7,150 followers View post →