Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.

Abstract in brief

• The review highlights that Rhodiola rosea contains around 140 compounds, including flavonoids, glycosides, and phenylethanoids, which contribute to its pharmacological activities such as adaptogenic, neuroprotective, cardioprotective, and antifatigue effects.
• Clinical studies show that Rhodiola extract can improve mental performance, reduce fatigue, and help with mild to moderate depression and anxiety, with the mechanisms involving interactions with stress-related hormone systems and protective proteins.
• Overall, Rhodiola rosea is considered safe with no significant adverse effects or drug interactions observed, making it a promising natural remedy for fatigue, cognitive enhancement, and mood improvement based on traditional, pharmacological, and clinical evidence.]