J Dermatol April 2010 PMID 20507402

Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts.

Hiroki Ohara, Satomi Ichikawa, Hitoshi Matsumoto, Minoru Akiyama, Norihiro Fujimoto, Takashi Kobayashi, Shingo Tajima

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Mentions

10
Peak: 1 in Jan 2021
across 3 sources since Jan 2021

Extended reach

340,108
potential audience

Total likes

8,641

Video views

339,429

Mentions per month

Jan 2021 – May 2024

Where it's discussed

  • News6 articles
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone indicates that social discussions recognize the significance of collagen-derived peptides like ProHyp in promoting skin health, with users referencing mechanisms like HAS2 gene activation and signaling pathways such as STAT3 phosphorylation. These examples, along with mentions of potential benefits for aging skin, highlight a shared interest and a moderate belief in the research's potential impact, driven by technical terminology and forward-looking language.

AgreementModerate agreement

Most posts acknowledge the positive effects of ProHyp on skin cell growth, showing general agreement with the research findings.

InterestModerate interest

Discussions reflect a moderate level of curiosity, as posters mention specific cellular pathways and potential applications in skincare.

EngagementHigh engagement

Many posts delve into the molecular mechanisms and implications, indicating a deep level of engagement with the scientific content.

ImpactModerate impact

The discussions suggest that the findings could influence future skincare formulations or therapies, although some posts remain speculative.

Abstract in brief

  • Collagen-derived dipeptide prolinehydroxyproline (ProHyp) significantly promotes human dermal fibroblast growth and hyaluronic acid production, crucial for skin health.
  • ProHyp's effects involve increasing HAS2 gene expression and activating signaling pathways, such as STAT3 phosphorylation, which are essential for cell proliferation and extracellular matrix formation.
  • Inhibiting key molecular pathways, like using siRNA against HAS2 or protein kinase inhibitors, reduces ProHyp's stimulation, indicating these pathways are vital for its activity in skin cell regeneration.

Top posts

Most liked on X and Bluesky
Amicus Dei sui indicta Avicenna
@Oculatus_abis · X

@s_fukuoka_bot Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S.

Jan 22, 2021 · 350 followers View post →
Careskinmedia
@careskinmedia · X

References: 10.3390/nu11102494 https://t.co/7ZNZBfpV1X 10.1159/000351376 10.1111/jocd.12174

Nov 23, 2021 · 330 followers View post →

All mentions

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This video explores the effects of regular sunscreen use and β-carotene supplements on skin aging. The study highlights that daily use of broad-spectrum sunscreen resulted in a 24% reduction in aging indicators over 4.5…

Physionic · May 29, 2024 238,958 views
Careskinmedia
@careskinmedia · X

References: 10.3390/nu11102494 https://t.co/7ZNZBfpV1X 10.1159/000351376 10.1111/jocd.12174

Nov 23, 2021 · 330 followers View post →
Amicus Dei sui indicta Avicenna
@Oculatus_abis · X

@s_fukuoka_bot Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S.

Jan 22, 2021 · 350 followers View post →