J Psychopharmacol April 2011 PMID 20643699

The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study.

Michael C Mithoefer, Mark T Wagner, Ann T Mithoefer, Lisa Jerome, Rick Doblin

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Mentions

26
Peak: 2 in Nov 2022
across 7 sources since Mar 2016

Extended reach

26,249
potential audience

Total likes

43

Video views

3,174

Mentions per month

Mar 2016 – Jun 2025

Where it's discussed

  • News12 articles
  • X / Twitter6 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook1 posts
  • Instagram1 posts
  • Reddit1 posts

AI synopsis

What people are saying

Discussions reflect a nuanced view, highlighting both the promising results of MDMA-assisted therapy and skepticism about the strength of formal evidence, as shown in comments about the research being 'light' due to Schedule 1 restrictions. Emotional language appears in posts advocating for veterans, indicating a desire for tangible social impact beyond academic findings.

AgreementModerate agreement

Most discussions acknowledge the potential benefits of MDMA-assisted psychotherapy based on existing research, though some express skepticism about formal studies and legal barriers.

InterestModerate interest

There is moderate interest shown, especially with mentions of veteran struggles and ongoing research, but some participants dismiss the topic due to perceived overexposure or legal issues.

EngagementNeutral engagement

The engagement levels are mixed; some posts briefly reference the study and anecdotal evidence, while others, like the call to action for helping veterans, show deeper emotional involvement.

ImpactModerate impact

There is a recognition that this research could influence treatment options and social discussions, evidenced by calls to action and references to veteran suicides and existing promising results.

Abstract in brief

  • This study is the first to evaluate the use of MDMA as an aid to psychotherapy for patients with treatment-resistant posttraumatic stress disorder (PTSD), showing promising results in reducing symptoms.
  • Participants were divided into two groups: one received MDMA during therapy sessions, and the other received a placebo; the MDMA group showed significantly greater improvement in PTSD symptoms at multiple follow-up points.
  • The treatment was generally safe, with no serious adverse effects or neurocognitive issues reported, suggesting MDMA-assisted psychotherapy could be a helpful option for patients who do not respond to traditional treatments.]

Top posts

Most liked on X and Bluesky
Amy Pomeroy
@LibertasPomeroy · X

Utah lost another vet to suicide last night. We've had the research for a decade showing that MDMA helps PTSD. https://t.co/6YlT27xyx8 Stop paying lip service to vets and DO something for vets. https://t.co/lVdv1YTtFG

Nov 21, 2022 · 5 likes · 1 share · 722 followers View post →
Sam McRoberts
@Sams_Antics · X

@cremieuxrecueil My guy, it’s all over. There are hundreds of first hand experiences out there, TONS of books covering it. Formal studies are light, Schedule 1 and all, but come on

Aug 11, 2024 · 3 likes · 5,359 followers View post →
lioromio
@lioromio · X

مراجع: https://t.co/NBHuGYVqgV

Apr 6, 2019 · 1 like · 14,467 followers View post →
el papafrita que tiene una gambita
@_ar0ni · X

@heyhey_itsgee https://t.co/wDNXzJnLQU https://t.co/tiYcAoVtbW https://t.co/mr8wTRuGSj

Jun 15, 2025 · 1 like · 108 followers View post →
Paotie Dawson
@Paotie · X

RT @LibertasPomeroy: Utah lost another vet to suicide last night. We've had the research for a decade showing that MDMA helps PTSD. https:/…

Nov 21, 2022 · 1 share · 2,111 followers View post →
Global_PharmD
@Global_PharmD · X

MDMA-Assisted Psychotherapy for PTSD uses the psychoactive substance MDMA, in conjunction with psychotherapy, to help individuals process and integrate traumatic experiences. An early study conducted by Mithoefer et al. in 2011 showed positive results

Mar 21, 2023 · 125 followers View post →

All mentions

el papafrita que tiene una gambita
@_ar0ni · X

@heyhey_itsgee https://t.co/wDNXzJnLQU https://t.co/tiYcAoVtbW https://t.co/mr8wTRuGSj

Jun 15, 2025 · 1 like · 108 followers View post →
Sam McRoberts
@Sams_Antics · X

@cremieuxrecueil My guy, it’s all over. There are hundreds of first hand experiences out there, TONS of books covering it. Formal studies are light, Schedule 1 and all, but come on

Aug 11, 2024 · 3 likes · 5,359 followers View post →
Global_PharmD
@Global_PharmD · X

MDMA-Assisted Psychotherapy for PTSD uses the psychoactive substance MDMA, in conjunction with psychotherapy, to help individuals process and integrate traumatic experiences. An early study conducted by Mithoefer et al. in 2011 showed positive results

Mar 21, 2023 · 125 followers View post →
Paotie Dawson
@Paotie · X

RT @LibertasPomeroy: Utah lost another vet to suicide last night. We've had the research for a decade showing that MDMA helps PTSD. https:/…

Nov 21, 2022 · 1 share · 2,111 followers View post →
Amy Pomeroy
@LibertasPomeroy · X

Utah lost another vet to suicide last night. We've had the research for a decade showing that MDMA helps PTSD. https://t.co/6YlT27xyx8 Stop paying lip service to vets and DO something for vets. https://t.co/lVdv1YTtFG

Nov 21, 2022 · 5 likes · 1 share · 722 followers View post →
lioromio
@lioromio · X

مراجع: https://t.co/NBHuGYVqgV

Apr 6, 2019 · 1 like · 14,467 followers View post →
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