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Am J Physiol Cell Physiol February 2011 PMID 21106691

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.

Insil Kim, John J Lemasters

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37
Peak: 1 in Oct 2018
across 5 sources since Oct 2018

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AI synopsis

What people are saying

Discussions reflect a keen interest in the biological process of mitophagy and its relevance during fasting, with comments citing mechanisms like mitochondrial fission and degradation, as seen in the mention of 'autophagy promotes' and 'mitochondrial breakdown.' The tone combines scientific curiosity with health-related implications, demonstrating engagement with both the research process and its potential applications.

AgreementModerate agreement

Most discussions acknowledge the significance of mitophagy during nutrient deprivation, with some referencing its role in cellular health and fasting benefits.

InterestHigh interest

Participants show high interest, often discussing mechanisms and implications for health, such as the mention of fasting and autophagy's role.

EngagementModerate engagement

The tone reflects a thoughtful engagement, with comments about molecular processes and potential health impacts, indicating a moderate depth of discussion.

ImpactModerate impact

While some discussions highlight the importance of understanding mitophagy for health and disease, overall impact appears moderate, with emphasis on biological mechanisms rather than broad societal change.

Abstract in brief

  • During nutrient deprivation, hepatocytes utilizing a GFP-LC3 transgenic mouse model show increased autophagy activity, where mitochondria are sequestered into autophagosomes called phagophores and rings.
  • The process of mitophagy includes mitochondrial fission, depolarization, and sequestration, with degradation of mitochondrial DNA (mtDNA) occurring inside acidified autolysosomes.
  • These findings demonstrate that preautophagic structures (PAS) serve as initiation sites for mitophagy in liver cells during fasting, involving mitochondrial breakdown and recycling of cellular components.]
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Rand ڕەند
@Randproject_ · X

23- https://t.co/jhFL5muDd0 24- https://t.co/nGFn6sump2 25- https://t.co/wkL3KG1Rl0 26- https://t.co/87oIE1dXCh 27- https://t.co/GmbV0ydXdm 28- https://t.co/RaGkt4ksrr 29- https://t.co/G8QYrnTCOY 30- https://t.co/gqA90EDfQq 31-  https://t.co/QtfR7bu7ru

Mar 14, 2024 · 1 like · 94 followers View post →
Clara Morrón
@AntojosdeClara · X

RT @calotonterias: @JulioBasulto_DN Ayuno: Promueve autofagia https://t.co/fg8oLtRYV4 https://t.co/imjQ6Kq7C0 q es uno d los mecanismos an…

Aug 4, 2020 · 13 shares · 381 followers View post →

All mentions

Rand ڕەند
@Randproject_ · X

23- https://t.co/jhFL5muDd0 24- https://t.co/nGFn6sump2 25- https://t.co/wkL3KG1Rl0 26- https://t.co/87oIE1dXCh 27- https://t.co/GmbV0ydXdm 28- https://t.co/RaGkt4ksrr 29- https://t.co/G8QYrnTCOY 30- https://t.co/gqA90EDfQq 31-  https://t.co/QtfR7bu7ru

Mar 14, 2024 · 1 like · 94 followers View post →
Tomás
@tomash97x · X

Autofagia y ayuno intermitente Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation https://t.co/4h7dnbkXEq

Apr 21, 2021 · 132 followers View post →
Clara Morrón
@AntojosdeClara · X

RT @calotonterias: @JulioBasulto_DN Ayuno: Promueve autofagia https://t.co/fg8oLtRYV4 https://t.co/imjQ6Kq7C0 q es uno d los mecanismos an…

Aug 4, 2020 · 13 shares · 381 followers View post →