Nature January 2011 PMID 21113150

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Mariela Jaskelioff, Florian L Muller, Ji-Hye Paik, Emily Thomas, Shan Jiang, Andrew C Adams, Ergun Sahin, Maria Kost-Alimova, Alexei Protopopov, Juan Cadiñanos, James W Horner, Eleftheria Maratos-Flier, Ronald A Depinho

Mentions

89
Peak: 10 in May 2021
across 6 sources since Dec 2019

Extended reach

138,151
potential audience

Total likes

1,930

Video views

88,596

Mentions per month

Dec 2019 – Nov 2025

Where it's discussed

  • News29 articles
  • X / Twitter25 posts
  • Blogs20 articles
  • Facebook11 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Most discussions reflect high interest through the frequent use of terms like 'telomeres,' 'aging,' and 'reversal,' suggesting curiosity about the potential applications of the research. Examples are the comment from @ScottAdamsSays questioning about life extension and posts mentioning ongoing studies, which reveal a moderate level of engagement and recognition of the research's potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some expressing curiosity or support, though a few pose questions about its implications.

InterestHigh interest

The topic of telomerase and aging clearly garners high interest, as reflected in numerous discussions emphasizing curiosity, such as mentions of 'telomeres,' 'aging,' and 'regeneration.'

EngagementModerate engagement

Posts show moderate engagement, with some participants sharing personal thoughts or referencing previous studies, indicating deeper consideration beyond mere acknowledgment.

ImpactModerate impact

While some discussions recognize the potential implications of reversing tissue degeneration, many focus on understanding the science rather than immediate societal impact.

Abstract in brief

  • The study investigates whether reactivating telomerase can reverse tissue damage caused by aging in mice with severe telomere dysfunction, showing that it can extend telomeres, reduce DNA damage, and restore cell proliferation in multiple organs.
  • Reactivating telomerase also reversed neurodegenerative changes by restoring neural progenitors, neurons, and glial cells, indicating potential for reversing neurodegeneration.
  • Overall, the findings suggest that endogenous telomerase reactivation offers a promising approach to reversing age-related tissue decline rather than just halting its progression.

Top posts

Most liked on X and Bluesky
Eleanor Sheekey
@EleanorSheekey · X

In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --> https://t.co/PxwyQS3XPl #telomeres #aging #telomerase #scicomm #AcademicYouTube @LongevityTech https://t.co/VKTkXZYUxO

May 21, 2021 · 26 likes · 8 shares · 4,889 followers View post →
Amarelowbr
@amarelowbr · X

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice https://t.co/I5nLB0ZNSY #telomero #telomerase #aging #envelhecimento #saude #doenças #telomeres

Jul 24, 2023 · 1 like · 845 followers View post →
DagobertIX
@DagobertIX · X

Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice (Jaskelioff et al., 2010) https://t.co/4oDTwG7FWy

Nov 17, 2025 · 1 like · 275 followers View post →
Monya Agouzoul
@monya_ag · X

https://t.co/SiTHObI2P4

Feb 8, 2024 · 1 like · 80 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/LinZy8yhXK La reactivación de la telomerasa revierte la degeneración tisular en ratones envejecidos con deficiencia de telomerasa En particular, la reactivación de la telomerasa somática revirtió la neurodegeneración con la restauración de la proliferación de

Jul 31, 2023 · 8,028 followers View post →
Based Hatter
@BasedHatter · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 4,511 followers View post →

All mentions

DagobertIX
@DagobertIX · X

Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice (Jaskelioff et al., 2010) https://t.co/4oDTwG7FWy

Nov 17, 2025 · 1 like · 275 followers View post →
Bill Walker
@BWalkerTTAGGG · X

@AlexanderMWolf7 @JellyfishDAO I spent five years watching them at Shay lab. https://t.co/6hzCyKA5pZ

May 14, 2025 · 1,384 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/OzSSZaeFxB

Nov 24, 2024 · 3,157 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/9S0a0kWsMm

Nov 24, 2024 · 3,157 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/97inGAXuVd

Nov 18, 2024 · 3,157 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/gver6keNqM

Nov 14, 2024 · 3,157 followers View post →
John Herman
@JohnHerman20720 · X

@ScottAdamsSays Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice. Do you really want to live forever or would you rather choose something different? I am ready for something different.

Aug 17, 2024 · 8 followers View post →
Monya Agouzoul
@monya_ag · X

https://t.co/SiTHObI2P4

Feb 8, 2024 · 1 like · 80 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/LinZy8yhXK La reactivación de la telomerasa revierte la degeneración tisular en ratones envejecidos con deficiencia de telomerasa En particular, la reactivación de la telomerasa somática revirtió la neurodegeneración con la restauración de la proliferación de

Jul 31, 2023 · 8,028 followers View post →
Amarelowbr
@amarelowbr · X

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice https://t.co/I5nLB0ZNSY #telomero #telomerase #aging #envelhecimento #saude #doenças #telomeres

Jul 24, 2023 · 1 like · 845 followers View post →
Mr. Brian Uberig
@Brian_Uberig · X

https://t.co/mnVsIQacxq

Apr 22, 2022 · 464 followers View post →
AlfredoPietracatella
@alfredopietraca · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 22, 2021 · 8 shares · 245 followers View post →
Asclepius
@dd414a1d9b59447 · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 22, 2021 · 8 shares · 2,270 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 22, 2021 · 8 shares · 2,106 followers View post →
Mia
@Miapugs · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 103 followers View post →
Soctt Rdeler
@emeliaaal · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 22 followers View post →
Yann F. Lecerf
@Yann_F_Lecerf · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 340 followers View post →
Based Hatter
@BasedHatter · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 4,511 followers View post →
Mairi Kilkenny
@mairikilkenny · X

RT @EleanorSheekey: In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --…

May 21, 2021 · 8 shares · 484 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

In this video I talk all about telomeres, why they shorten, how telomerase restores them and how it's all regulated! --> https://t.co/PxwyQS3XPl #telomeres #aging #telomerase #scicomm #AcademicYouTube @LongevityTech https://t.co/VKTkXZYUxO

May 21, 2021 · 26 likes · 8 shares · 4,889 followers View post →
alon
@alamo2914 · X

@davidasinclair @StanfordMed What about the telomerase study from 2010 (https://t.co/dgnoP8ZhkD)? There were are also some compelling studies done in vitro before, for example: doi: 10.1083/jcb.200704141.

May 13, 2020 · 5 followers View post →
Juan José Arango E.
@jjarangoes · X

Esto me ha parecido escandaloso: https://t.co/rgUcnxXXnT

Dec 11, 2019 · 2,680 followers View post →
Juan José Arango E.
@jjarangoes · X

Creo que esto puede resultarles de interés: @NanyPardo @DCoronell @yohirakerman @ReveladosCol @darosselli @JulieDuque1 @MJDuzan @mapatilla https://t.co/HAQNhPLhWC

Dec 8, 2019 · 2,680 followers View post →
Juan José Arango E.
@jjarangoes · X

RT @jjarangoes: Espero les resulte de interés. El enlace al video completo está al final de este post y como primer comentario. https://t.c…

Dec 8, 2019 · 1 share · 2,680 followers View post →
Juan José Arango E.
@jjarangoes · X

Espero les resulte de interés. El enlace al video completo está al final de este post y como primer comentario. https://t.co/HAQNhPLhWC

Dec 7, 2019 · 1 share · 2,680 followers View post →