PubHawk
January 2011 PMID 21226578

Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.

Amit V Khera, Marina Cuchel, Margarita de la Llera-Moya, Amrith Rodrigues, Megan F Burke, Kashif Jafri, Benjamin C French, Julie A Phillips, Megan L Mucksavage, Robert L Wilensky, Emile R Mohler, George H Rothblat, Daniel J Rader

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Mentions

12
Peak: 1 in Oct 2019
across 5 sources since Oct 2019

Extended reach

22,538
potential audience

Total likes

193

Video views

17,028

Mentions per month

Oct 2019 – Mar 2025

Where it's discussed

  • News3 articles
  • Blogs3 articles
  • X / Twitter2 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions reflect a high level of engagement with phrases like 'more predictive than HDL level' and notes about 'significant determinants,' which demonstrate interest and understanding. Comments about HDL's role and potential as a biomarker highlight the perceived impact of the findings, while the tone remains analytical and focused on scientific details, emphasizing the relevance and importance of the research.

AgreementModerate agreement

Most discussions acknowledge the importance of cholesterol efflux capacity as a predictor for cardiovascular risk, supporting the article's conclusions.

InterestHigh interest

The posts show strong interest by highlighting key findings, such as HDL function being more predictive than HDL levels alone.

EngagementModerate engagement

Comments reference specific measures and implications, indicating moderate to deep understanding and engagement with the research.

ImpactModerate impact

Discussions emphasize the significance of HDL functionality in understanding cardiovascular health, suggesting a meaningful impact on future research or clinical practice.

Abstract in brief

  • The study suggests that HDL's ability to promote cholesterol removal from macrophages (efflux capacity) is linked to lower atherosclerotic burden and coronary artery disease, independent of HDL cholesterol levels.
  • Cholesterol efflux capacity explains less than 40% of the variation in HDL levels but remains a strong predictor of cardiovascular health, indicating it could be a valuable biomarker for assessing heart disease risk.
  • Treatments like pioglitazone can improve HDL function (efflux capacity) in patients with metabolic syndrome, though statins do not have the same effect, highlighting potential differences in how therapies influence HDL's protective roles.]
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Top posts

Most liked on X and Bluesky
Dr Kevin Lee
@dr_kevinlee · X

cholesterol efflux capacity measurement more predictive than HDL level in predicting #CVD risk factors https://t.co/RJ4A1my6dt https://t.co/Rp3tFjixCC

Oct 12, 2019 · 1 like · 5,428 followers View post →
Adam Jaworski
@adam__jaworski · X

@Kamil_Paprotny @Kto72102356 Średnica, zdoln. do odp. orient. przestrz, itd -> spełniana funkcja HDL lub nie The levels of HDL cholesterol and apolipoprotein A-I were significant determinants of cholesterol efflux capacity but accounted for less than 40% of the observed variation. https://t.co/IzSMXQo9Ge

Jun 14, 2020 · 82 followers View post →

All mentions

Adam Jaworski
@adam__jaworski · X

@Kamil_Paprotny @Kto72102356 Średnica, zdoln. do odp. orient. przestrz, itd -> spełniana funkcja HDL lub nie The levels of HDL cholesterol and apolipoprotein A-I were significant determinants of cholesterol efflux capacity but accounted for less than 40% of the observed variation. https://t.co/IzSMXQo9Ge

Jun 14, 2020 · 82 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

cholesterol efflux capacity measurement more predictive than HDL level in predicting #CVD risk factors https://t.co/RJ4A1my6dt https://t.co/Rp3tFjixCC

Oct 12, 2019 · 1 like · 5,428 followers View post →