PubHawk
Am J Physiol Regul Integr Comp Physiol June 2011 PMID 21451146

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle.

Jonathan P Little, Adeel Safdar, David Bishop, Mark A Tarnopolsky, Martin J Gibala

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Mentions

23
Peak: 2 in Aug 2020
across 6 sources since Oct 2019

Extended reach

188,521
potential audience

Total likes

181

Video views

5,892

Mentions per month

Oct 2019 – Nov 2025

Where it's discussed

  • X / Twitter8 posts
  • News6 articles
  • YouTube3 videos
  • Facebook3 posts
  • Blogs2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The comments reflect a positive reception, with users expressing interest in how interval training enhances mitochondrial function, as shown by phrases like 'mito biogenesis stays elevated' and questions about what stimulates mitochondrial proliferation. The tone combines curiosity and support, emphasizing the potential importance of the research for fitness and health.

AgreementModerate agreement

Most discussions acknowledge the findings, recognizing the role of high-intensity interval training (HIIT) in promoting mitochondrial biogenesis, indicating a general consensus of support.

InterestHigh interest

The posts demonstrate high curiosity about the mechanisms and effects of mitochondrial proliferation, with some asking specific questions about stimulation pathways.

EngagementModerate engagement

Posts show moderate engagement, with some users referencing molecular processes and practical implications, and others sharing their personal experiences or questions.

ImpactModerate impact

The discussions suggest that the research has a meaningful impact on understanding exercise physiology and influencing training practices, though it remains at an early stage.

Abstract in brief

  • An acute session of high-intensity interval training (HIT) stimulates mitochondrial biogenesis in human skeletal muscle, primarily by increasing the nuclear levels of PGC1, a key regulator of this process.
  • Molecular analysis showed that exercise activates signaling pathways like p38 MAPK and AMPK, leading to increased PGC1 in the nucleus and subsequent upregulation of mitochondrial genes during recovery.
  • The study indicates that even a brief, intense workout can enhance mitochondrial capacity in muscles through these molecular mechanisms, with measurable increases in mitochondrial proteins and activity observed 24 hours post-exercise.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Gemma Goldie
@gemagoldie · X

Y qué estimula la proliferación mitocondrial? Pues, por ejemplo, el entrenamiento por intervalos https://t.co/DjgDjLqfJ2

Aug 14, 2020 · 14 likes · 2 shares · 28,839 followers View post →
L ❤ V E
@drkohilathas · X

@nothxjstlooking Yes. "An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle." https://t.co/KAHB7Tg2mX

Jun 29, 2023 · 5 likes · 47,983 followers View post →
Denis, NP
@Denis_protocol · X

@PeterAttiaMD https://t.co/u60UsyZlF4

Mar 26, 2023 · 5 likes · 3 shares · 9,136 followers View post →
Abud Bakri MD
@AbudBakri · X

@CoffeeBlackMD I havent found any good head to head, but the mito biogenesis here stays elevated for 24h+ https://t.co/UvNYCGcuZe

Jan 16, 2025 · 3 likes · 52,197 followers View post →
Richard
@PGC1a_RB · X

RT @Denis_protocol: @PeterAttiaMD https://t.co/u60UsyZlF4

Jan 9, 2025 · 3 shares · 14,748 followers View post →
Richard
@PGC1a_RB · X

RT @Denis_protocol: @PeterAttiaMD https://t.co/u60UsyZlF4

Jan 17, 2024 · 3 shares · 14,748 followers View post →

All mentions

Abud Bakri MD
@AbudBakri · X

@CoffeeBlackMD I havent found any good head to head, but the mito biogenesis here stays elevated for 24h+ https://t.co/UvNYCGcuZe

Jan 16, 2025 · 3 likes · 52,197 followers View post →
Richard
@PGC1a_RB · X

RT @Denis_protocol: @PeterAttiaMD https://t.co/u60UsyZlF4

Jan 9, 2025 · 3 shares · 14,748 followers View post →
medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

Blood Pressure Variability and Autonomic Response to an Acute Bout of High Intensity Interval Exercise in Healthy Young Adults https://www.medrxiv.org/content/10.1101/2024.01.29.24301957v1

Jan 30, 2024 View post →
Richard
@PGC1a_RB · X

RT @Denis_protocol: @PeterAttiaMD https://t.co/u60UsyZlF4

Jan 17, 2024 · 3 shares · 14,748 followers View post →
Richard
@PGC1a_RB · X

RT @Denis_protocol: @PeterAttiaMD https://t.co/u60UsyZlF4

Dec 9, 2023 · 3 shares · 14,748 followers View post →
L ❤ V E
@drkohilathas · X

@nothxjstlooking Yes. "An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle." https://t.co/KAHB7Tg2mX

Jun 29, 2023 · 5 likes · 47,983 followers View post →
Denis, NP
@Denis_protocol · X

@PeterAttiaMD https://t.co/u60UsyZlF4

Mar 26, 2023 · 5 likes · 3 shares · 9,136 followers View post →
mafalda
@ftb_abril · X

RT @gemagoldie: Y qué estimula la proliferación mitocondrial? Pues, por ejemplo, el entrenamiento por intervalos https://t.co/DjgDjLqfJ2

Aug 14, 2020 · 2 shares · 200 followers View post →
Gemma Goldie
@gemagoldie · X

Y qué estimula la proliferación mitocondrial? Pues, por ejemplo, el entrenamiento por intervalos https://t.co/DjgDjLqfJ2

Aug 14, 2020 · 14 likes · 2 shares · 28,839 followers View post →