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Discussion examples include references to the proofreading enzyme nsp14, its role in mutation rate control, and how this influences virus adaptability and vaccine resistance. The tone is scientifically engaged and emphasizes the importance of the findings for future research and antiviral strategies.
Most posts support the article, emphasizing the role of the proofreading mechanism and its importance for understanding viral mutation rates, which aligns with the scientific content.
The discussions reflect high engagement and curiosity about the mechanisms, potential antiviral strategies, and the implications for virus evolution and vaccine development.
Multiple comments reference detailed concepts like the RNA proofreading enzyme nsp14, mutation rates, and antiviral drug implications, showing deep involvement.
Posts highlight the significance of the research for virology, antiviral development, and understanding virus evolution, indicating high perceived impact.
has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; their polymerase has a high fidelity to "proofreading" when they mutate. You just have been hearing about mutations lately in news. https://t.co/HMRVrf4QGb
The discovery of a protein distinct from a viral RdRp that regulates replication fidelity also raises the possibility that RNA genome replication fidelity may be adaptable to differing replication environments and selective pressures. https://t.co/cv3jN0pEeL https://t.co/j1DAg0npMD
Why does Remdesivir fail? The same reason why Cov2 mutates slowly - a proofreading gene https://t.co/4bqsBWzx5P While the virus is replicating its genome (think of it as chain), Remdesivir is a "bad" link - after which the chain cant be built nsp14 removes that bad link
Again, you have no idea of what you're talking about; influenza does not know that we have a 365 day year. You sound like a moron. https://t.co/1DuDoghT13
@AgWxMan1 @EricTopol @pathogenomenick @clivecookson @ian_bott_artist Flu mutates much faster, coronaviruses have a proofreader of sorts that slows the mutation rate. https://t.co/NlwwuWZ4Rw
@AbundantLandUse @ChMacArthur @ianwrob @NickytaLeb @fitterhappierAJ ‘bout that proofreading mechanism: “possibility that RNA genome replication fidelity may be adaptable to differing replication environments and selective pressures, rather than being a fixed determinant.” https://t.co/I0woHPke4D
The 2019 novel coronavirus outbreak began in Wuhan, China, leading to the first confirmed case in the United States. This video provides insights into how the virus's mild symptoms can swiftly worsen, highlighting the…
Coronaviruses have the largest and most complex RNA genomes among RNA viruses, requiring a delicate balance between mutation rates for adaptation and maintaining a functional genome. The virus encodes a protein, nsp14…
Coronaviruses An RNA proofreading machine regulates replication fidelity and diversity (2011) https://t.co/EyvUGCPTeU https://t.co/zQzANw28yA
@JosetteSchoenma @wolfeagle1989 @HNimanFC "serves either as a direct mediator or regulator of a more complex RNA proofreading machine, a process previously unprecedented in RNA virus biology" The key reference by Bloom is SARS regulates the translation. This doesn't infer proper translation. https://t.co/BvwgT3gkRy
"Genetic inactivation of ExoN activity in engineered SARS-CoV and MHV genomes by alanine substitution .. results in viable mutants that demonstrate 15- to 20-fold increases in mutation rates, .." (2011) https://t.co/Abtc2iNn1M ..
RT @kevinpurcell: More on the “all RNA viruses have copy errors so they mutate rapidly” but SARS-CoV and SARS-CoV-2 have a proofreading sys…
RT @tommy_cleary: @pathogenetics Even Nature has limits... irony hurts math most when an antiviral rate of CoV genetic mutation is proposed…
@pathogenetics Even Nature has limits... irony hurts math most when an antiviral rate of CoV genetic mutation is proposed by idea this particular FCS can be found in anything wild. <<Mutagenesis has also been proposed to work as an antiviral strategy>> https://t.co/WFCWQIwAY0 https://t.co/5Hys1AxPDH
@R_H_Ebright Additionally; opposing the mantra <<chance of this occurring naturally>> there are undone science effects here to be considered too? For PRRAR:SVAS? Chance plays NO role! It cannot! The level of mutagenesis required/proposed is actually ANTIVIRAL! https://t.co/WFCWQIeZzq https://t.co/TE3MCMJVEw
@mmajrk @Florin_Uncovers @pathogenetics @Daoyu15 fairly sure the answer would have a little more current context than this older @Baric_Lab paper... anyone else? https://t.co/WFCWQIeZzq
@mmajrk @Florin_Uncovers @pathogenetics @Daoyu15 I am upset as I asked @Daoyu15 last night about Wang & Anderson's work on limits to wild CoV recombination <<CoVs have evolved to contain an exoribonuclease which increases the fidelity of RNA genome replication>> basically inserts just don't happen? https://t.co/0XxPp2TZ8W https://t.co/tpVfiuo8MR
RT @tomtanya84: @ClemensLode @hjelle_brian Although NSP14-exoN itself is a proofreader, it’s part of a “regulated fidelity” complex with ns…
@AbundantLandUse @ChMacArthur @ianwrob @NickytaLeb @fitterhappierAJ ‘bout that proofreading mechanism: “possibility that RNA genome replication fidelity may be adaptable to differing replication environments and selective pressures, rather than being a fixed determinant.” https://t.co/I0woHPke4D
@x2IndSpeculator @hjelle_brian This paper? https://t.co/JsFn0WxqA8
RT @DaleCooperBack: #covid #variants Coronaviruses: an #RNA #proofreading machine regulates #replication #fidelity and #Diversity https:…
#covid #variants Coronaviruses: an #RNA #proofreading machine regulates #replication #fidelity and #Diversity https://t.co/V0z2a6Z4xm Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting https://t.co/GjnZhbv7DN
RT @medicalnews2020: 2011 "In order to survive and propagate, RNA viruses must achieve a balance between the capacity for adaptation to new…
The discovery of a protein distinct from a viral RdRp that regulates replication fidelity also raises the possibility that RNA genome replication fidelity may be adaptable to differing replication environments and selective pressures. https://t.co/cv3jN0pEeL https://t.co/j1DAg0npMD
RT @medicalnews2020: 2011 "In order to survive and propagate, RNA viruses must achieve a balance between the capacity for adaptation to new…
2011 "In order to survive and propagate, RNA viruses must achieve a balance between the capacity for adaptation to new environmental conditions or host cells with the need to maintain an intact and replication competent genome. " https://t.co/N9ah8vyzIS
RT @tomtanya84: @ClemensLode @hjelle_brian Although NSP14-exoN itself is a proofreader, it’s part of a “regulated fidelity” complex with ns…
@ClemensLode @hjelle_brian Although NSP14-exoN itself is a proofreader, it’s part of a “regulated fidelity” complex with nsp12-rdrp and nsp10. This allows the virus to turn the error rate up when conditions are unfavorable. Look for papers with “regulated fidelity cov”. https://t.co/fyFyXcStLn
@RWMaloneMD nsp14-mediated proofreading [might influence] the balance between fidelity, diversity and pathogenesis. RNA genome replication fidelity may be adaptable to differing replication environments and selective pressures, rather than being a fixed determinant. https://t.co/bXjes4IhyS
@PierreKory https://t.co/0GgC9bzmjt
@eh_den CoVs are very resistant to increased mutation rates. That adds another question about #Molnupiravir. https://t.co/o13qLKqaQL
@pathogenetics @DaveAtkinsonMD @halvorz @mrandersoninneo @stuartjdneil @Pityu7070 @R_H_Ebright @Maestermagoo @BooFinley @mccarthy_kr Had to look that one up! I don't think that s considered hifi.... This looks like a nice review of the process at play https://t.co/PFp2j5vAtK
@NuritBaytch @ChristinaVirgil @mugecevik @DrNeilStone @BradSpellberg COVID proofreads. It has a mutation rate orders of magnitude lower than other RNA viruses. https://t.co/CImFKH3ECl It also does not have a segmented genome that allows for recombination, like the flu. This is virology 101.
@ItsNoGood101 @riddlerhombus @USATODAY Published article from 2011 mentioned (at the time) SARS-CoV has a faster rate of viable mutations. Granted we’re talking about the new novel SARS-CoV-2, but the longer it has time to infect and the more people that can be infected, the greater the risk. https://t.co/xTw50iDoax https://t.co/twqaT7olzQ
RT @JT_Grindrod: @AgWxMan1 @EricTopol @pathogenomenick @clivecookson @ian_bott_artist Flu mutates much faster, coronaviruses have a proofre…
@AgWxMan1 @EricTopol @pathogenomenick @clivecookson @ian_bott_artist Flu mutates much faster, coronaviruses have a proofreader of sorts that slows the mutation rate. https://t.co/NlwwuWZ4Rw
@Pensive_Bonobo حاجی من منظورم استعاری بود بیشتر ولی مثکه واقعا داره :)) https://t.co/OSdPtzpP6B
@23Ides Scientists have studied coronavirus for many years. Coronavirus genetics has been researched for many yrs since it has the ability to mutate rapidly with multiple variety of receptors. Baric & others dedicate much time to it. Note year & references yrs. https://t.co/A6pEkpMULN
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
@cantina_guy @Kalle3D @ViolaPriesemann Influenzaviren mutieren aber schneller. Diese Coronaviren haben eine "proofreading"-Funktion im Genom, wie mir neulich jemand erklärt hat. https://t.co/eF8WeUpOIv
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/FddgEVakOs
RT @sanchak74: @JTL794Gulag @pook_tweets @wittgenstein78 @GirishNaught @nikhil_k56 @VishnuFNO @Rita_Banerji 2/2 .. have to really thank nsp…
@JTL794Gulag @pook_tweets @wittgenstein78 @GirishNaught @nikhil_k56 @VishnuFNO @Rita_Banerji 2/2 .. have to really thank nsp14 https://t.co/4bqsBWzx5P Other RNA viruses dont have this Vaccination has other problems (untested, long-term safety, efficacy), but not making new variants...
https://t.co/pBmA0pajH8
Again, you have no idea of what you're talking about; influenza does not know that we have a 365 day year. You sound like a moron. https://t.co/1DuDoghT13
RT @sanchak74: Why does Remdesivir fail? The same reason why Cov2 mutates slowly - a proofreading gene https://t.co/4bqsBWzx5P While the v…
RT @sanchak74: Why does Remdesivir fail? The same reason why Cov2 mutates slowly - a proofreading gene https://t.co/4bqsBWzx5P While the v…
RT @sanchak74: Why does Remdesivir fail? The same reason why Cov2 mutates slowly - a proofreading gene https://t.co/4bqsBWzx5P While the v…
Why does Remdesivir fail? The same reason why Cov2 mutates slowly - a proofreading gene https://t.co/4bqsBWzx5P While the virus is replicating its genome (think of it as chain), Remdesivir is a "bad" link - after which the chain cant be built nsp14 removes that bad link
RT @sanchak74: Reminder that Cov2 doesnt mutate anyway NEARLY as fast as flu does Because of proof-reading gene that doenst allow it https…
RT @sanchak74: Reminder that Cov2 doesnt mutate anyway NEARLY as fast as flu does Because of proof-reading gene that doenst allow it https…
RT @sanchak74: Reminder that Cov2 doesnt mutate anyway NEARLY as fast as flu does Because of proof-reading gene that doenst allow it https…
Reminder that Cov2 doesnt mutate anyway NEARLY as fast as flu does Because of proof-reading gene that doenst allow it https://t.co/4bqsBWzx5P https://t.co/m4M32a7Yyj
RT @sanchak74: Also know that flu mutates much much faster (Cov2 has a proofreading gene nsp14 that doesnt allow it to mutate fast - https…
RT @sanchak74: Also know that flu mutates much much faster (Cov2 has a proofreading gene nsp14 that doesnt allow it to mutate fast - https…
RT @sanchak74: Also know that flu mutates much much faster (Cov2 has a proofreading gene nsp14 that doesnt allow it to mutate fast - https…
Also know that flu mutates much much faster (Cov2 has a proofreading gene nsp14 that doesnt allow it to mutate fast - https://t.co/4bqsBWzx5P) https://t.co/lOMfnSWJ72
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/FddgEVakOs
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
RT @MonicaGandhi9: has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; th…
has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; their polymerase has a high fidelity to "proofreading" when they mutate. You just have been hearing about mutations lately in news. https://t.co/HMRVrf4QGb
rather than being a fixed determinant. https://t.co/FddgEVakOs
RT @sanchak74: @tomaspueyo And there is a reason - Covs have a proof-reading enzyme that tries to fix error as much as possible. Of course…
RT @sanchak74: @tomaspueyo And there is a reason - Covs have a proof-reading enzyme that tries to fix error as much as possible. Of course…
RT @sanchak74: @tomaspueyo And there is a reason - Covs have a proof-reading enzyme that tries to fix error as much as possible. Of course…
RT @sanchak74: @tomaspueyo And there is a reason - Covs have a proof-reading enzyme that tries to fix error as much as possible. Of course…
@tomaspueyo And there is a reason - Covs have a proof-reading enzyme that tries to fix error as much as possible. Of course, they also try to evade antibodies - and the SA variant has probably managed that, but it often comes at a trade-off cost, lower efficiency https://t.co/4bqsBWzx5P
@DrDomPimenta https://t.co/NlwwuWZ4Rw
@angie_rasmussen Do coronavirus proofread? https://t.co/Llu2Z9U6vh
On the proofreading activity of coronavirus RNA polymerase. Worth reading! https://t.co/3cjJIrVF5o
@pjchatfield @eugenegu https://t.co/WEyVNdUmTa
@indysorger11 @SabineBr3 @Karl_Lauterbach Ich weiß als Mechanismus nur von der Exoribonuklease durch das NSP-14. Genaueres im Paper unten, aber nur englisch. https://t.co/ggRAYqNk0K
@beeoliberal @rtbkc @Ultrasound700 @BadMedicalTakes That is correct they have a proofreader that discards the "mistakes" that would normally be a mutation. https://t.co/NlwwuWZ4Rw
RT @LifeEarthEnvLSK: Open Access Review: Coronaviruses https://t.co/NRT4ku0eIA #openaccess #openscience #coronavirus #COVID19 #COVID #RNA
Open Access Review: Coronaviruses https://t.co/NRT4ku0eIA #openaccess #openscience #coronavirus #COVID19 #COVID #RNA
RT @tandfnewsroom: Back in the news this week, this 2011 study by researchers at @VanderbiltU and @UNC explains how #coronavirus has a "pro…
Back in the news this week, this 2011 study by researchers at @VanderbiltU and @UNC explains how #coronavirus has a "proofreading" protein that helps it replicate itself and infect cells in the body, https://t.co/zh8IhM1k0L @tandfmedicine https://t.co/rTtCzqfijp
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/cnKI8o3wVU
@stormsc @AstralLobo @molosgatos @WHO That's true. As an epidemiologist explained, viruses such as #COVID19 contain "genetic proofreaders" in order to survive but which also sometimes can make them difficult to combat. https://t.co/jCwoohp2CO
@NodibL @TroncheBiais https://t.co/gCsH17htB9
@balajis @alexey_r @PeterKolchinsky Coronaviruses also have a proofreading enzyme that keeps their mutation rate fairly low, and is a target of some experimental antiviral drugs. https://t.co/CnufiEnbyN https://t.co/5ICyekkU0O
Coronaviruses: An RNA Proofreading Machine Regulates Replication Fidelity and Diversity - PubMed https://t.co/7eqk0GDXDd Watch the proofreading like a hawk. Mutations here can break vaccines by mass diversity. Flu has no proofreading which is why we see it every year https://t.co/A7umI7UHJl
@PeterKolchinsky Finishing the story: CoVs evolved xtra hi-fidelity RNA replication to support their huge genomes. https://t.co/eXVVEnjO2e
@SystemsVirology Nice review from Baric and colleagues! https://t.co/vRIylDQCjv
More on the “all RNA viruses have copy errors so they mutate rapidly” but SARS-CoV and SARS-CoV-2 have a proofreading system. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. https://t.co/6pwZCBty9j
@carlzimmer @V2019N More on the “all RNA viruses have copy errors so they mutate rapidly” but SARS-CoV and SARS-CoV-2 have a proofreading system. Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. https://t.co/6pwZCBty9j
RT @EurekaMag: Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/MK6qKxUdeg
RT @EurekaMag: Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/MK6qKxUdeg
Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity https://t.co/MK6qKxUdeg
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