Psychopharmacology (Berl) December 2011 PMID 21674151

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects.

Roland R Griffiths, Matthew W Johnson, William A Richards, Brian D Richards, Una McCann, Robert Jesse

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Mentions

31
Peak: 3 in May 2021
across 7 sources since Oct 2012

Extended reach

117,063
potential audience

Total likes

764

Video views

30,260

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Oct 2012 – Nov 2025

Where it's discussed

  • X / Twitter13 posts
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AI synopsis

What people are saying

Discussions focus on the key findings of the study—particularly that higher doses of psilocybin induce significant mystical experiences—and express curiosity about the implications for therapy and wellbeing. The tone varies from supportive to interested, with examples like mentioning the doses (20-30 mg) and referencing the study’s potential influence on psychedelics research, illustrating a blend of acknowledgment and curiosity about future applications.

AgreementModerate agreement

Most discussions acknowledge the study's findings on dose-related mystical experiences, indicating general support or acceptance of the research results.

InterestHigh interest

The discussions reflect high interest, with multiple mentions of the study's details, implications, and potential therapeutic benefits.

EngagementModerate engagement

Participants reference specific studies, doses, and subjective effects, showing active engagement but not deep scientific critique.

ImpactModerate impact

While there's acknowledgment of the research's importance, the impact perception is moderate, emphasizing potential but not suggesting transformative societal changes.

Abstract in brief

  • This study investigated how different doses of psilocybin can induce mystical experiences and long-lasting positive changes in mood, attitude, and behavior in adults.
  • Higher doses (20 and 30 mg/70 kg) caused more intense effects, including feelings of fear and mystical experiences, which were rated as meaningful and remained significant even 14 months later.
  • The results suggest that under supportive conditions, psilocybin can produce both immediate and lasting benefits, with effects increasing as the dose increases, highlighting its potential for therapeutic use.

Top posts

Most liked on X and Bluesky
Nick Jikomes
@trikomes · X

In the 2011 Johns Hopkins study (link below) where they looked at different doses of pure psilocybin, they found that the two highest doses (20 and 30 mg psilocybin per 1 kg of body weight) induced "mystical-type experiences" in most people. 5/ https://t.co/zscLU2kcXZ

Jul 6, 2020 · 8 likes · 10,913 followers View post →
roger plunk
@rogerplunk · X

@PaulAustin3w @thirdwaveishere In a 2011 study by Johns Hopkins, "Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects" on doses ranging from 5 to 30 mg of ps, it was found that 20mg had the highest benefits with lowest challenges.

Aug 18, 2023 · 7 likes · 107 followers View post →
Nick Jikomes
@trikomes · X

A 2011 Johns Hopkins study by @Drug_Researcher and co (link below) looked at different doses of #psilocybin. They found that the two highest doses (20 and 30 mg psilocybin per 70 kg body weight) induced "mystical-type experiences" in most people. 5/ https://t.co/wO4jL5o93Q

May 4, 2021 · 6 likes · 10,913 followers View post →
Sansero Life Sciences
@Sansero_Life · X

Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects: https://t.co/FFsBScHjmn #psilocybin #psilocybinresearch #psychedelics

Aug 6, 2020 · 2 likes · 95 followers View post →
Nick Jikomes
@trikomes · X

@DevWallace1 https://t.co/u7VTuBFICd Use this article to get the paper if you can't access it: https://t.co/zPZD9YcMvi

May 7, 2021 · 1 like · 10,913 followers View post →
David B. Yaden
@ExistWell · X

@DrCMBurritt @CLOSLER @JHPsychedelics @N_Gukasyan @drjanaway @michaelpollan I see evidence for some real risk of adverse effects - but "immense destruction"? No - that statement doesn't appear to be grounded in the available evidence... https://t.co/iIPFIMzmaR https://t.co/Mu61Clc2Aw https://t.co/ZcULnDCSzd https://t.co/T8xnOMGj9V https://t.co/1ef1pGCyNr

Sep 16, 2022 · 1 like · 7,205 followers View post →

All mentions

roger plunk
@rogerplunk · X

@PaulAustin3w @thirdwaveishere In a 2011 study by Johns Hopkins, "Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects" on doses ranging from 5 to 30 mg of ps, it was found that 20mg had the highest benefits with lowest challenges.

Aug 18, 2023 · 7 likes · 107 followers View post →
TGalps
@siFp1 · X

@myRed_5 @rogerplunk @N_Gukasyan https://t.co/fLiZ8vN4iV

Nov 13, 2022 · 1 like · 17 followers View post →
Ben Smith
@curiouskiwicat · X

@MichaelDPlant ...there's also all sorts of subjective changes ppts report, but that sounds like the sort of thing you're aware of already. imho good quality research is pretty sparse at this point, but due to lack of evidence, not failed attempts to find evidence https://t.co/93tBg8Ajyg

Oct 21, 2022 · 633 followers View post →
David B. Yaden
@ExistWell · X

@DrCMBurritt @CLOSLER @JHPsychedelics @N_Gukasyan @drjanaway @michaelpollan I see evidence for some real risk of adverse effects - but "immense destruction"? No - that statement doesn't appear to be grounded in the available evidence... https://t.co/iIPFIMzmaR https://t.co/Mu61Clc2Aw https://t.co/ZcULnDCSzd https://t.co/T8xnOMGj9V https://t.co/1ef1pGCyNr

Sep 16, 2022 · 1 like · 7,205 followers View post →
cyral_callender
@CallenderCyral · X

In some of the pioneering psilocybin studies (https://t.co/7Y4svMU5D3) done at Johns Hopkins University, controlled doses of psilocybin were administered to patients.

Sep 10, 2022 · 36 followers View post →
Anastasie
@Psychanastasie · X

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects [Roland R. Griffiths, Matthew W. Johnson, et al. Psychopharmacology volume 218, pages649–665 (2011)] https://t.co/GEcA8VDxHT https://t.co/EtcJxV43YS

Jul 13, 2021 · 11,993 followers View post →
Anastasie
@Psychanastasie · X

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects [Roland R Griffiths, Matthew W Johnson, et al. Psychopharmacology (Berl). 2011 Dec;218(4):649-65. doi: 10.1007/s00213-011-2358-5.] https://t.co/v9kQfqnljd

Jun 26, 2021 · 11,993 followers View post →
Nick Jikomes
@trikomes · X

@DevWallace1 https://t.co/u7VTuBFICd Use this article to get the paper if you can't access it: https://t.co/zPZD9YcMvi

May 7, 2021 · 1 like · 10,913 followers View post →
Nick Jikomes
@trikomes · X

RT @trikomes: A 2011 Johns Hopkins study by @Drug_Researcher and co (link below) looked at different doses of #psilocybin. They found tha…

May 5, 2021 · 10,913 followers View post →
Nick Jikomes
@trikomes · X

A 2011 Johns Hopkins study by @Drug_Researcher and co (link below) looked at different doses of #psilocybin. They found that the two highest doses (20 and 30 mg psilocybin per 70 kg body weight) induced "mystical-type experiences" in most people. 5/ https://t.co/wO4jL5o93Q

May 4, 2021 · 6 likes · 10,913 followers View post →
Sansero Life Sciences
@Sansero_Life · X

Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects: https://t.co/FFsBScHjmn #psilocybin #psilocybinresearch #psychedelics

Aug 6, 2020 · 2 likes · 95 followers View post →
Nick Jikomes
@trikomes · X

RT @trikomes: In the 2011 Johns Hopkins study (link below) where they looked at different doses of pure psilocybin, they found that the two…

Jul 7, 2020 · 10,913 followers View post →
Nick Jikomes
@trikomes · X

In the 2011 Johns Hopkins study (link below) where they looked at different doses of pure psilocybin, they found that the two highest doses (20 and 30 mg psilocybin per 1 kg of body weight) induced "mystical-type experiences" in most people. 5/ https://t.co/zscLU2kcXZ

Jul 6, 2020 · 8 likes · 10,913 followers View post →
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