Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.

Andrew S Doré, Nathan Robertson, James C Errey, Irene Ng, Kaspar Hollenstein, Ben Tehan, Edward Hurrell, Kirstie Bennett, Miles Congreve, Francesca Magnani, Christopher G Tate, Malcolm Weir, Fiona H Marshall

September 2011 Structure

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The discussions reflect a casual attitude towards the publication, with mentions of caffeine and biochemistry that suggest a basic interest but little engagement, such as 'Caffeine biochemistry' and comments about personal schedules and energy levels. The tone is relaxed and informal, emphasizing personal reactions rather than scientific implications.

A
Agreement
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There is a mild interest, especially in the mention of biochemistry and caffeine, which are relatable topics.

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The comments are light and casual, indicating minimal deep involvement with the research details.

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Impact
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The overall discussion does not seem to influence opinions or actions significantly; it remains casual and personal.

Social Mentions

YouTube

2 Videos

Twitter

1 Posts

Blogs

2 Articles

News

3 Articles

Metrics

Video Views

2,225

Total Likes

39

Extended Reach

2,510

Social Features

8

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Adenosine Receptor Structure and Caffeine Binding Insights

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the bumbling biochemist

January 25, 2022

2,154 views

Understanding How Caffeine Stimulates the Brain at a Molecular Level

Understanding How Caffeine Stimulates the Brain at a Molecular Level

Caffeine, the world's most popular stimulant, blocks adenosine receptors in the brain. Recent structural studies reveal how caffeine and related compounds bind to the adenosine A2A receptor, informing new approaches for neurological disease treatments.

xtal_xlear

March 18, 2021

71 views

  • Hannah Landis
    @whohannah (Twitter)

    It looks like she's doing this while she's on an eliptical. This is my kind of energy. Best part of today was finding this YouTube channel. Also send help, I will probably have to reschedule my Biochemistry test again Caffeine biochemistry https://t.co/HrCGABjyQo via @YouTube
    view full post

    February 14, 2022

Abstract Synopsis

  • The study presents the crystal structures of the adenosine A2A receptor in complex with various ligands, including xanthines like caffeine, XAC, and the inverse agonist ZM241385, revealing its inactive state with a specific salt bridge called the ionic lock.
  • These structures offer new understanding of how different ligands bind within the receptor's pocket and highlight the receptor’s intracellular regions involved in signal transduction, which is important for developing drugs to treat conditions like Parkinson's disease.
  • Methylxanthines such as caffeine are common stimulants that work by blocking adenosine receptors, and the detailed structural data can help improve their therapeutic properties or develop new treatments for neurological diseases.]