Cell Metab October 2011 PMID 21982712

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Jun Yoshino, Kathryn F Mills, Myeong Jin Yoon, Shin-ichiro Imai

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Peak: 1 in Nov 2021

across 5 sources since Nov 2021

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What people are saying

The discussions reflect a neutral reception, with some posts mentioning molecular pathways like inflammation, oxidative stress, and circadian rhythms, highlighting interest in biochemical mechanisms but lacking detailed debate or strong opinions. The use of technical terms and references to related metabolic processes suggests a basic level of engagement with the scientific content, but the overall tone remains cautious and exploratory rather than definitive.

AgreementModerate agreement

Most discussions acknowledge the significance of NMN's role in addressing diet- and age-related diabetes, indicating general agreement with the publication's findings.

InterestModerate interest

The posts show moderate interest, with references to NAD+ and metabolic processes, but lack of enthusiasm or detailed critique suggests a neutral to mild interest.

EngagementNeutral engagement

The conversation seems limited, with only one post briefly mentioning related gene expression pathways, indicating superficial engagement rather than deep analysis.

ImpactModerate impact

Participants seem to recognize the potential influence of NMN in metabolic health, but the overall tone doesn’t reflect a belief in immediate or widespread impact.

Abstract in brief

Nicotinamide mononucleotide (NMN) is a key compound in NAD production that can help treat type 2 diabetes (T2D) caused by high-fat diets and aging by restoring NAD levels in the body.
High-fat diets and aging reduce NAD biosynthesis, impairing important metabolic processes, but NMN supplementation improves glucose tolerance, insulin sensitivity, and reduces inflammation and stress-related gene expression.
These findings suggest that NMN could be a promising nutraceutical to combat diet- and age-related T2D by enhancing NAD levels and activating beneficial pathways like SIRT1.]

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Evaluating NMN as a Potential Anti-Aging Supplement

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Dr. Hernández-Reyes, A. RD, MSc, PhD

@albertohdez · X

>>>la expresión génica relacionada con la inflamación, estrés oxidativo y ritmos circadianos (10.1016/j.cmet.2011.08.014).

Jan 21, 2023 · 2 likes · 2,025 followers View post →

Adrian ionuț Roncea 0771391930

@roncea_adrian · X

Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice https://t.co/6fa6xLGgnh

Nov 14, 2021 · 1 like · 40 followers View post →