PLoS Genet October 2011 PMID 22022279

Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.

Amaury Vaysse, Abhirami Ratnakumar, Thomas Derrien, Erik Axelsson, Gerli Rosengren Pielberg, Snaevar Sigurdsson, Tove Fall, Eija H Seppälä, Mark S T Hansen, Cindy T Lawley, Elinor K Karlsson, Danika Bannasch, Carles Vilà, Hannes Lohi

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AI synopsis

What people are saying

Discussions emphasize specific genomic loci, like MSRB3 & HMGA2, associated with physical and behavioral traits, indicating a strong interest in the genetic basis of breed differences. The tone suggests appreciation for the detailed findings without extensive critique or exploration of broader implications.

AgreementModerate agreement

The discussion shows a general positive recognition of the research findings, emphasizing specific loci and traits, indicating support or validation of the study's significance.

InterestHigh interest

The detailed mention of genomic regions, loci, and traits demonstrates a high level of interest in the scientific details and implications.

EngagementModerate engagement

The mention of specific genetic markers and traits suggests the poster is engaged with the technical aspects of the research, though the discussion does not delve into broader implications or criticisms.

ImpactModerate impact

While the discussion highlights important genetic regions, the overall tone suggests recognition of the study’s relevance but not necessarily its transformative impact yet.

Abstract in brief

The study analyzed the genomes of 509 dogs from 46 breeds to identify regions under selection that contribute to the wide variety of physical and behavioral traits, using high-density SNP genotyping.
Researchers found 44 genomic regions highly differentiated across breeds, with variations linked to traits like size and ear shape, and identified many long homozygous regions suggesting recent selective sweeps.
The findings highlight specific genomic areas potentially responsible for phenotypic diversity, especially those containing developmental genes, and provide a foundation for understanding the genetic basis of complex traits in dogs.]

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All mentions

Dog Ear Genetics and Phenotypic Variation in Breeds

This video explores the genetics behind dog ear shapes, including wide, round, pointy, and cocked ears, discussing how genetic factors and gravity influence ear positioning and shape, with insights from recent genomic…

little hungry warrior · Jun 1, 2025 4,764 views

Dog Genetics and Morphology: Key Traits and Genetic Regions Explained

Analyzes dog phenotypic traits and their genetic bases, focusing on linked loci, inheritance models, and specific genomic regions associated with physical features like size and ear shape, highlighting findings from…

little hungry warrior · Sep 1, 2025 2,720 views

Carlos E Alvarez

@CarlosEAlvare17 · X

Apr 24, 2023 · 1,173 followers View post →

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News

doi:10.1371/journal.pgen.1000529. 165 55. Zhou X, Stephens M (2012) Genome-wide efficient mixed-model analysis for association studies.

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