Nature November 2011 PMID 22048312

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen

Mentions

213
Peak: 11 in Oct 2021
across 7 sources since Feb 2020

Extended reach

279,765
potential audience

Total likes

1,870

Video views

61,491

Mentions per month

Feb 2020 – Sep 2025

Where it's discussed

  • News136 articles
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  • Bluesky1 posts

AI synopsis

What people are saying

Discussions reflect a strong interest in the mechanisms behind aging, with comments referencing the heterogeneity of senescent cells and their markers, and some critique media overhyping therapies like hyperbaric oxygen. The tone is generally supportive of the research's potential impact but wary of overstated claims, emphasizing both scientific complexity and hope for practical advances.

AgreementModerate agreement

Most discussions support the idea that clearing senescent cells can delay aging-related issues, with some highlighting the significance of p16Ink4a pathways.

InterestHigh interest

The topic of cellular senescence and its link to aging sparks high curiosity, especially with references to specific markers and therapeutic strategies.

EngagementModerate engagement

Comments show moderate engagement, including references to scientific concepts like heterogeneity of senescent cells and markers such as high-p21 expression.

ImpactModerate impact

There’s a shared belief that this research could have meaningful implications for aging and age-related diseases, though some skepticism about media hype is noted.

Abstract in brief

  • Advanced age is a key factor in chronic diseases, but the underlying mechanisms of aging are not fully understood, complicating efforts to find ways to combat age-related issues.
  • Cellular senescence stops damaged cells from dividing and builds up with age, potentially harming tissue function, yet it's unclear if removing these cells can improve health.
  • A novel transgene called INK-ATTAC allows for the targeted elimination of senescent cells in aging mice, and the study finds that removing these cells can delay age-related problems and even improve existing conditions.

Top posts

Most liked on X and Bluesky
Eleanor Sheekey
@EleanorSheekey · X

The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I discuss high-p21 expression as a marker and whether clearing these cells could be beneficial. --> https://t.co/MMNlcG01xR #aging #scicomm #AcademicYouTube https://t.co/SQigUwe1of

Oct 16, 2021 · 21 likes · 9 shares · 4,877 followers View post →
米将軍
@okome_show · X

@toshism0331 別のターゲットで2011年にも同じような実験が発表されてます https://t.co/7fLtPYTF20 老化は最近のすげぇホットな領域です!!

Jan 14, 2021 · 8 likes · 97,036 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

The overhyped media on hyperbaric oxygen therapy for reversing aging https://t.co/UTLTlFXoeU via @YouTube #hyperbarico2 #aging #news #scicomm #AcademicYouTube

Nov 26, 2020 · 8 likes · 1 share · 4,877 followers View post →
Agingdoc
@agingdoc1 · X

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (2011) https://t.co/oXwmngtpNh

Jun 12, 2023 · 6 likes · 41,323 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness If #scicomm interests you, these also discuss & affirm my initial expressed concern re media overhyping here: 1)https://t.co/kRniEhSo9J (fun j club!) 2)https://t.co/57kuAxruFN 3)https://t.co/NhFHWsK22b Enjoy!-@agingdoc1 PS-@foundmyfitness is a hype-free zone, nice job Rhonda.

Nov 29, 2020 · 1 like · 1 share · 41,074 followers View post →
Based Hatter
@BasedHatter · X

RT @agingdoc1: @foundmyfitness If #scicomm interests you, these also discuss & affirm my initial expressed concern re media overhyping here…

Nov 29, 2020 · 1 share · 4,517 followers View post →

All mentions

Andrew Steele
@statto.bsky.social · Bluesky

At 75 years, the NHS is now old enough that (if it were a human!) it would likely be suffering from multiple chronic diseases. For it (another other health services) to succeed over the next 75 years, they will need to address ageing: https://youtube.com/watch?v=tNn-2TXzSaA

Jul 5, 2023 · 1 share View post →
Agingdoc
@agingdoc1 · X

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (2011) https://t.co/oXwmngtpNh

Jun 12, 2023 · 6 likes · 41,323 followers View post →
Gohsuke Takama
@gohsuket · X

....〆(・ω・。) "Why and where do senescent cells form?" on YouTube https://t.co/OuLqybKBbl

Mar 14, 2023 · 2,993 followers View post →
Gol.d
@Gull_King · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 28, 2021 · 9 shares · 312 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 27, 2021 · 9 shares · 2,111 followers View post →
#BBCResistance
@seenandheard22 · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 18, 2021 · 9 shares · 239 followers View post →
ScienceStop
@B0tSci · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 18, 2021 · 9 shares · 4,081 followers View post →
Charlene Boumendil, she/her
@CharleneBoumen1 · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 18, 2021 · 9 shares · 633 followers View post →
Juan Fafián-Labora
@fafian_juan · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 16, 2021 · 9 shares · 1,006 followers View post →
Alex Freeman
@alex__freeman · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 16, 2021 · 9 shares · 38 followers View post →
waking_up_dormancy
@WDormancy · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 16, 2021 · 9 shares · 29 followers View post →
ScienceStop
@B0tSci · X

RT @EleanorSheekey: The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I…

Oct 16, 2021 · 9 shares · 4,081 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

The senescent state is heterogeneous. This makes identifying all & only senescent cells in vivo challenging. Here I discuss high-p21 expression as a marker and whether clearing these cells could be beneficial. --> https://t.co/MMNlcG01xR #aging #scicomm #AcademicYouTube https://t.co/SQigUwe1of

Oct 16, 2021 · 21 likes · 9 shares · 4,877 followers View post →
exRNA
@exRNA · X

#RNATx2021 Myriam Gorospe @NIH #NIA Selective elimination of senescent cells can promote healthy aging https://t.co/wSmfgPGxX6 #senolytics = class of drugs that eliminate senescent cells

Jun 24, 2021 · 2,149 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Ageing-related publications that make us believe in Senolytics medicine: https://t.co/Sw8Uba3Nwd https://t.co/I6PmkYrqWP https://t.co/7XMVDdGCAK

Feb 3, 2021 · 876 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

https://t.co/I6PmkYrqWP "life-long removal of p16(Ink4a)-expressing cells delayed onset of these phenotypes. Furthermore, late-life clearance attenuated progression of already established age-related disorders." https://t.co/Sw8Uba3Nwd

Feb 3, 2021 · 876 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders https://t.co/I6PmkYrqWP "In tissues--such as adipose tissue, skeletal muscle and eye--in which p16(Ink4a) contributes to the acquisition of age-related pathologies" https://t.co/Sw8Uba3Nwd

Feb 3, 2021 · 876 followers View post →
米将軍
@okome_show · X

@toshism0331 別のターゲットで2011年にも同じような実験が発表されてます https://t.co/7fLtPYTF20 老化は最近のすげぇホットな領域です!!

Jan 14, 2021 · 8 likes · 97,036 followers View post →
Based Hatter
@BasedHatter · X

RT @agingdoc1: @foundmyfitness If #scicomm interests you, these also discuss & affirm my initial expressed concern re media overhyping here…

Nov 29, 2020 · 1 share · 4,517 followers View post →
Agingdoc
@agingdoc1 · X

@foundmyfitness If #scicomm interests you, these also discuss & affirm my initial expressed concern re media overhyping here: 1)https://t.co/kRniEhSo9J (fun j club!) 2)https://t.co/57kuAxruFN 3)https://t.co/NhFHWsK22b Enjoy!-@agingdoc1 PS-@foundmyfitness is a hype-free zone, nice job Rhonda.

Nov 29, 2020 · 1 like · 1 share · 41,074 followers View post →
Blake Gossard
@BlakeGossard · X

The overhyped media on hyperbaric oxygen therapy for reversing aging https://t.co/ryfqdXqLhq via @YouTube

Nov 27, 2020 · 30 followers View post →
jakkdl
@jakkdl · X

@TheZvi re oxygen lifespan study: https://t.co/jYRMI8VPOS

Nov 27, 2020 · 155 followers View post →
Academic YouTubers
@YTacademics · X

RT @EleanorSheekey: The overhyped media on hyperbaric oxygen therapy for reversing aging https://t.co/UTLTlFXoeU via @YouTube #hyperbarico2…

Nov 26, 2020 · 1 share · 2,111 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

The overhyped media on hyperbaric oxygen therapy for reversing aging https://t.co/UTLTlFXoeU via @YouTube #hyperbarico2 #aging #news #scicomm #AcademicYouTube

Nov 26, 2020 · 8 likes · 1 share · 4,877 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders https://t.co/I6PmkYrqWP https://t.co/ev3fKAQQ7D

Sep 13, 2020 · 876 followers View post →
Arktist
@Arktist · X

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders https://t.co/6PrazBTygx

Feb 9, 2020 · 909 followers View post →