FASEB J February 2012 PMID 22049059

Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway.

Tsung-Hua Hsieh, Cheng-Fang Tsai, Chia-Yi Hsu, Po-Lin Kuo, Jau-Nan Lee, Chee-Yin Chai, Shao-Chun Wang, Eing-Mei Tsai

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Mentions

69
Peak: 8 in Jan 2024
across 3 sources since Jul 2012

Extended reach

512,738
potential audience

Total likes

17,680

Video views

474,662

Mentions per month

Jul 2012 – Nov 2025

Where it's discussed

  • News50 articles
  • YouTube10 videos
  • X / Twitter9 posts

AI synopsis

What people are saying

The discussions reveal a general consensus that the study is important, with posts highlighting the potential health risks posed by phthalates and emphasizing the need for further research. Words like 'significant,' 'impactful,' and references to pathways and public health issues illustrate both engagement and recognition of the study's importance.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with many accepting the findings on phthalates' role in cancer progression.

InterestHigh interest

Many posts demonstrate high curiosity and concern about the environmental and health implications of the study.

EngagementModerate engagement

Participants actively reference related pathways, such as HDAC6 and c-Myc, and discuss broader impacts on public health policies.

ImpactModerate impact

The discussions reflect a belief that this research could influence future studies and health guidelines, indicating a moderate but meaningful impact.

Abstract in brief

  • The study found that phthalates like BBP and DBP promote growth, movement, invasion, and tumor formation in estrogen receptor-negative breast cancer cells by activating the AhR receptor and a specific signaling pathway involving cAMP, PKA, and CREB1.
  • This pathway leads to increased levels of HDAC6, which helps assemble a transcription complex that boosts the expression of the cMyc oncogene, contributing to cancer progression.
  • Overall, the research uncovers a new way that phthalates can promote breast cancer growth outside of their traditional estrogenic effects, highlighting a potential environmental risk factor for hormone-independent breast cancers.

Top posts

Most liked on X and Bluesky
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@SilkeLeFay · X

@medical_xpress @AACR #cancer #breastcancer #publichealth #metabolomics #methylomics #health #sustainability #NCDs #SDGs #exposome Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/ngzcANX6kE

Aug 6, 2020 · 2 likes · 1 share · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

@medical_xpress @NorthwesternU @ScienceAdvances #MYC Butyl benzyl phthalate promotes prostate cancer cell proliferation through the miR-34a/c-myc axis. https://t.co/oKDo79Vrp6 Phthalates induce proliferation of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway https://t.co/RP3uT3YL1q

Jun 6, 2022 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#cancer #breastcancer #NCDs #publichealth #epidemiology #metabolomics #health #sustainability #methylomics Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/eRO563wOOA

Nov 1, 2020 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#breastcancer #womenshealth #ecotoxicology #HDAC #immunology #exposome #publichealth #endocrinology #oncology Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/RP3uT3YL1q

Dec 30, 2023 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

@medical_xpress @PNASNews . Phthalates induce proliferation of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/RP3uT3YL1q

Mar 25, 2023 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#breastcancer #publichealth #womenshealth #healthpromotion #epidemiology #NCDs #sustainability #GreenNewDeal Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/eRO563wOOA

May 9, 2021 · 4,585 followers View post →

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For health-promoting environments
@SilkeLeFay · X

#breastcancer #womenshealth #ecotoxicology #HDAC #immunology #exposome #publichealth #endocrinology #oncology Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/RP3uT3YL1q

Dec 30, 2023 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

@medical_xpress @PNASNews . Phthalates induce proliferation of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/RP3uT3YL1q

Mar 25, 2023 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#womenshealth #oncology Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/ngzcANG3iE

Mar 21, 2023 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

@medical_xpress @NorthwesternU @ScienceAdvances #MYC Butyl benzyl phthalate promotes prostate cancer cell proliferation through the miR-34a/c-myc axis. https://t.co/oKDo79Vrp6 Phthalates induce proliferation of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway https://t.co/RP3uT3YL1q

Jun 6, 2022 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#breastcancer #publichealth #womenshealth #healthpromotion #epidemiology #NCDs #sustainability #GreenNewDeal Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/eRO563wOOA

May 9, 2021 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#breastcancer #agedcare #NCDs #publichealth Hair concentrations of phthalate metabolites need to be monitored. Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/eRO563wOOA

Jan 7, 2021 · 4,585 followers View post →
For health-promoting environments
@SilkeLeFay · X

#cancer #breastcancer #NCDs #publichealth #epidemiology #metabolomics #health #sustainability #methylomics Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/eRO563wOOA

Nov 1, 2020 · 4,585 followers View post →
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@interexposome · X

RT @SilkeLeFay: @medical_xpress @AACR #cancer #breastcancer #publichealth #metabolomics #methylomics #health #sustainability #NCDs #SDGs #e…

Aug 6, 2020 · 1 share · 896 followers View post →
For health-promoting environments
@SilkeLeFay · X

@medical_xpress @AACR #cancer #breastcancer #publichealth #metabolomics #methylomics #health #sustainability #NCDs #SDGs #exposome Phthalates induce proliferation and invasiveness of estrogen receptor‐negative breast cancer through the AhR/HDAC6/c‐Myc signaling pathway . https://t.co/ngzcANX6kE

Aug 6, 2020 · 2 likes · 1 share · 4,585 followers View post →
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