Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study.

Abstract in brief

• ARA supplementation in healthy elderly Japanese individuals increased plasma phospholipid ARA levels in a dose-dependent manner but did not affect their metabolites or clinical markers related to cardiovascular, inflammatory, or allergic diseases.
• The elevated ARA levels returned to baseline after a 4-week washout period, and no significant changes were observed in other fatty acids or clinical parameters during the study.
• Overall, supplementing with ARA-enriched oil appears safe for the elderly, as it does not alter key metabolites or clinical indicators associated with inflammation, allergies, or cardiovascular health.