Association of methylentetraydrofolate reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study.

Abstract in brief

• This study examined whether a specific genetic variation (MTHFR 677 C T polymorphism) is linked to psoriasis vulgaris and homocysteine levels in Malaysian patients and found no significant association between the gene mutation and the skin condition.
• The research revealed that psoriasis patients did not have higher homocysteine levels than healthy controls, and the gene mutation did not influence homocysteine or related vitamin levels significantly.
• However, in psoriasis patients, homocysteine levels were negatively correlated with vitamin B12 and folic acid, meaning higher vitamin levels were associated with lower homocysteine, but this did not relate directly to the MTHFR gene variation.