The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Carhart-Harris showed subjects resting with eyes closed while tripping on IV psilocybin had cold, dark MRI. https://t.co/RJ0pQXlYsB https://t.co/845QrDVHFA
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin.
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Jul 2020 – Dec 2025Where it's discussed
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What people are saying
Overall, the discussions show high enthusiasm and curiosity about how psilocybin impacts brain activity, with examples like references to the decrease in default mode network activity, citations of influential research, and comments describing the study as transformative or game-changing. The tone and words—such as 'key to understanding,' 'groundbreaking,' and 'empirical meat'—highlight a strong recognition of its significance in neuroscience and psychology.
Most discussions acknowledge the significance of the findings, especially noting the study as a 'game-changer' and emphasizing its role in understanding psychedelics' effects on the brain.
Participants exhibit high curiosity, referencing related studies, citations, and implications, demonstrating strong engagement with the topic.
Posts include mentions of methodologies, comparisons with other research, and interpretations of brain activity changes, reflecting active and thoughtful involvement.
The discussions highlight the study's potential to influence neuroscience and psychology, with some calling it essential or groundbreaking research that could shape future understanding.
Abstract in brief
- This study used fMRI techniques to investigate how psilocybin affects brain activity, revealing that it causes decreases in blood flow and activity in key brain regions like the thalamus and cingulate cortex, which are involved in consciousness and cognition.
- A notable finding was the consistent decrease in activity in the medial prefrontal cortex (mPFC) and decreased connectivity between the mPFC and posterior cingulate cortex (PCC), suggesting that psilocybin reduces communication in brain hubs crucial for normal thought processes.
- These changes in brain activity and connectivity are linked to the altered states of consciousness experienced under psychedelics, implying that their effects might be due to disrupted activity in the brain's core connector regions, leading to unconstrained or altered thinking.]
Top posts
Most liked on X and Bluesky10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain under the influence of #psilocybin, with surprising results, helping to kickstart the modern #PsychedelicRenaissance Find out more: https://t.co/eCsdGL0wQD
Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes more sense to me (& replicates previous work e.g., https://t.co/psLeSy9X0C). What does it mean? Still an open question: https://t.co/bygtbOjM2i https://t.co/9SV9nOaRCd
Then this started to put some more serious empirical meat on the bone: https://t.co/zBWsEZN1jg https://t.co/dtzOE6tgZC
robin carhart-harris's study, "neural correlates of the psychedelic state as determined by fMRI studies with psilocybin," is a game-changer, showing how psychedelics alter brain activity. with over 1490 citations, it's key to understanding the neurobiology of psychedelics.
mg for mg, DMT is less potent than psilocybin. 1-2 mg intravenous psilocybin (https://t.co/IZhQjLRQjs, https://t.co/NikryCvGyy) produces similar effects as 10+ mg intravenous DMT (https://t.co/eL3ob0ExX3, https://t.co/RfLy7tyQ14, https://t.co/Bix7IWxHUl). 2/7
All mentions
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@Doggedpursuited @MiddleOfMayhem Reality is a constrained hallucination. It takes energy to keep the constraints on. Letting go is easy and brings in the ghosts, aliens, & Faries. https://t.co/hWa4js0RoE
@MEHMETK030201 @reha37 Yani durum Reha beyin dediği gibi. Beyin, dış dünya uyaranlarını filtreler nitelikte. Neden peki? Atomları görürsen "parçaları" göremezsin, üzerine gelen bir kaplanı da! Aynısı dalga boyu, tayf vb. için de geçerli. Doğal seçilim böylesini becerebilmiş.. https://t.co/MxpV47EyKQ
@StuartHameroff https://t.co/MDVc1KMyni this psilocybin study that you mentioned concurs in finding with recent study by @MatthewSacchet @winsonfzyang where they also found that reduced DMN activity led to increased quality of awareness https://t.co/LGUGYWH6t3
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/B9M4TYVZG8
Sources: Al-Ezzi et al. (2021) Analysis of Default Mode Network in Social Anxiety Disorder: EEG Resting-State Effective Connectivity Study. https://t.co/QLr9k3tHqQ Carhart-Harris et al. (2012) Neural correlates of the psychedelic state as determined by fMRI studies with
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
RT @BeeARDai: robin carhart-harris's study, "neural correlates of the psychedelic state as determined by fMRI studies with psilocybin," is…
robin carhart-harris's study, "neural correlates of the psychedelic state as determined by fMRI studies with psilocybin," is a game-changer, showing how psychedelics alter brain activity. with over 1490 citations, it's key to understanding the neurobiology of psychedelics.
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin | PNAS https://t.co/ZRF99j5Y7j
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
@Unthought10 The paper shared by Stuart Hameroff in his reply to my question that I retweeted, but you have to click through to see it https://t.co/Y6rsgg8XR9
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
RT @StuartHameroff: The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Car…
The energetic cost of consciousness is very low, compared to cognition which requires membrane potentials, ATP etc. Carhart-Harris showed subjects resting with eyes closed while tripping on IV psilocybin had cold, dark MRI. https://t.co/RJ0pQXlYsB https://t.co/845QrDVHFA
@maqart55 @AnitaBeerToday @misfitparade03 @prochoicewoman7 https://t.co/ewCjc6ju6U https://t.co/8sjmfYyEQ8 https://t.co/vyic1F4NCI https://t.co/w1pFONKB9Y https://t.co/5frIf0KZEs
RT @RCarhartHarris: Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes m…
RT @RCarhartHarris: Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes m…
RT @RCarhartHarris: Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes m…
RT @RCarhartHarris: Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes m…
Nice to see this important paper from @KatrinPreller and co. I look forward to reading. Changes in absolute CBF makes more sense to me (& replicates previous work e.g., https://t.co/psLeSy9X0C). What does it mean? Still an open question: https://t.co/bygtbOjM2i https://t.co/9SV9nOaRCd
@puwulitics @PsilocybinSf @TEDxMarin 1. Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., ... & Nutt, D. J. (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences, 109(6), 2138-2143.
mg for mg, DMT is less potent than psilocybin. 1-2 mg intravenous psilocybin (https://t.co/IZhQjLRQjs, https://t.co/NikryCvGyy) produces similar effects as 10+ mg intravenous DMT (https://t.co/eL3ob0ExX3, https://t.co/RfLy7tyQ14, https://t.co/Bix7IWxHUl). 2/7
@VikkiKingMD @TheDailyShroom https://t.co/3CzDI5NnLW Very interesting
https://t.co/vbml1dwcQj
@TimmyJSDavis @RCarhartHarris @sdpnayak For most impactful in neuroscience this comes immediately to mind https://t.co/NW8zqUDHXb For most impactful in experimental psychology this comes to mind https://t.co/QM6L8W0RVZ These 2 got me excited to start working in this field.
RT @RCarhartHarris: Then this started to put some more serious empirical meat on the bone: https://t.co/zBWsEZN1jg https://t.co/dtzOE6tgZC
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin | Proceedings of the National Academy of Sciences https://t.co/65IaJ7PBUn
RT @RCarhartHarris: Then this started to put some more serious empirical meat on the bone: https://t.co/zBWsEZN1jg https://t.co/dtzOE6tgZC
Then this started to put some more serious empirical meat on the bone: https://t.co/zBWsEZN1jg https://t.co/dtzOE6tgZC
@tedcooke Psilocybin decreases activity measured by fmri: https://t.co/IcAUFR6aZD
https://t.co/eV0GTofNDa
r/neuroscience - Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/7k8CJCAmd4
r/neuroscience - Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/3LgQH6ucge
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/MkYnM854zn
@zach_haigney https://t.co/nkr88boasS
@Through_Leaves @neuroDaws @NatureMedicine @RCarhartHarris @ProfDavidNutt And in this pioneering 2012 study: https://t.co/r307VNvKik
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/qrvWAM3uXs
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
RT @BeckleyResearch: 10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain…
10 years ago, the Beckley/Imperial #Psychedelic Research Programme published the very first images of the human brain under the influence of #psilocybin, with surprising results, helping to kickstart the modern #PsychedelicRenaissance Find out more: https://t.co/eCsdGL0wQD
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/PEsHprsAfY
A psilocibina também diminui a atividade da rede de modo padrão (Default Mode Network) que geralmente está aumentada na depressão e em processos de ruminação https://t.co/hS4Q72ejQl https://t.co/YlGALS9Dzo
RT @Psychanastasie: Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin [Proc Natl Acad Sci U S A . 20…
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin [Proc Natl Acad Sci U S A . 2012 Feb 7;109(6):2138-43. doi: 10.1073/pnas.1119598109. Epub 2012 Jan 23.] https://t.co/CaZ0E2HCwM https://t.co/bZVvR1yDZi
From the Cover: Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin https://t.co/VAOkmHGNNE
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