When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linoleic acid -> industrial seed oils. https://t.co/ZFsh9U48eS https://t.co/PA272Bzmku
Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity.
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Jan 2019 – Oct 2025Where it's discussed
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What people are saying
The discussions reflect strong agreement, with numerous examples mentioning controlled mouse studies showing seed oils cause obesity and emphasizing the harmful effects of omega-6 fats; words like 'proof' and 'evidence' demonstrate high engagement and perceived impact, emphasizing the importance of avoiding seed oils to combat obesity.
Most discussions support the findings of the publication, emphasizing seed oils' role in obesity.
Discussions show high engagement and curiosity about mechanisms and implications
Many posts reference studies, suggest experiments, and debate dietary impacts, indicating deep involvement
The widespread sharing of studies and advocacy for dietary changes suggest recognition of significant health implications
Abstract in brief
- Dietary intake of linoleic acid (LA) increases levels of certain endocannabinoids (2AG and AEA) in tissues, which promotes overeating and obesity in mice.
- Raising LA from 1% to 8% of energy intake elevated arachidonic acid (AA) in tissues and led to increased food consumption, fat gain, and obesity; this mimics the rise in LA consumption seen in the U.S. during the 20th century.
- Including omega-3 fats like EPA and DHA in the diet can counteract LA's obesogenic effects by reducing the endocannabinoid tone and normalizing fat metabolism, preventing diet-induced obesity.]
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Most liked on X and BlueskyThis mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets. Mice eating 1% linoleic acid gained less fat than those eating 8%. But I found the results a bit odd so I thought I'd look into it. https://t.co/9GcvwauZKB https://t.co/eXdrQalmM9
Pork sausage clocked in at 14.6% of calories from linoleic acid. 8% of calories from LA makes mice fat in the lab. You still eating that high-PUFA pork for breakfast? https://t.co/Jxyde6hYxG https://t.co/QXvPkQdAbV
The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the obesogenic effect https://t.co/vAYGUEwTPz
Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. One might say they give you the munchies 24/7. https://t.co/ZFsh9U48eS
Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely correlate with increasing prevalence rates of obesity. https://t.co/vAYGUEwTPz
All mentions
Nutrition Debate: Butter vs Margarine for Heart Health
Nutrition Debate is a weekly series featuring nutritionist Felipe Viana and Henrique Autran. They discuss dietary choices, including a randomized trial comparing coconut oil, olive oil, and butter, focusing on their…
Processed PUFA's Role in Metabolic Disease and Obesity Risk
Dietary linoleic acid increases levels of endocannabinoids in tissues, promoting overeating and obesity. Raising LA intake from 1% to 8% of energy content elevates tissue arachidonic acid, leading to weight gain…
@caloriesproper2 Let's do a study with humans that is the equivalent of 1 day in rodents: Look Ma! No problem with seed oils. Meanwhile: https://t.co/c89wJIT2G6
@mct4health I'm reading your fructose bothers fat post. I assume you've seen Alvheim's study of 1% vs. 8% LA, showing that high-fat diets are only obesogenic at high enough LA%? (https://t.co/QwbUIZ6BSh) The carbohydrate components of all the diets contain sucrose, but I can't
@trikomes I've noticed that "anhydrous milkfat" seems really obesogenic for mice, whereas using actual butter in the Alvheim studies left the mice lean. https://t.co/QwbUIZ6BSh Maybe ask him what the difference there could be? Also 47% protein is just absurd lol @TuckerGoodrich
RT @SolBrah: Study here: https://t.co/jiZEF3fq0H
@cancerclasses @GareyCozad @bigfatsurprise thanks for posting that! i found this study which looked at Omega 6 and obesity in mice. https://t.co/al8MkxJPFp this showed that a diet with 8% LA versus a control of 1% with same calories led to obesity.
Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity (2012) https://t.co/0H7j0YULMe https://t.co/OT7J4UaDp0
Because they're cheap and profitable, seed oils are in almost all ultra-processed foods. Study: To make rats obese, feed them seed oils. Reducing seed oil reverses the obesogenic effect. https://t.co/jIqcDIcarz
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
@SwipeWright https://t.co/znxQhesxT8 https://t.co/AyMw6cJeWG https://t.co/GxXNmsSI8L https://t.co/OWhimcUOUy https://t.co/FzNfKgHNO9 https://t.co/JShaKK4w4O https://t.co/w9ZKnscBeT https://t.co/LlgM2kLsvR https://t.co/LCedGaoblE https://t.co/m1xQ6WjDKB
食事リノール酸(LA)→内因性2-AG,anandamide(AEA)⬆️ 肥満を誘発 https://t.co/8hln9VVHFQ 2-AG,AEAは膜リン脂質(AA-PL)の必須脂肪酸アラキドン酸(AA)(20:4n-6)から合成 リン脂質前駆体pool AAは食事LA(18:2n-6)かω3,特にEPA,DHA摂取⬇️→⬆️ AEA,2-AGがcannabinoid受容体(CB1,CB2)⬆️ →食欲⬆️脂肪貯蔵⬆️ https://t.co/4IExyavMBR
@JFC_Bass_Chant @Leo_Abstract @mold_time @ESYudkowsky @turchin Try this one then, in which linoleic acid causes obesity, and reducing linoleic acid reverses obesity: https://t.co/QwbUIZ6BSh
@JFC_Bass_Chant @Leo_Abstract @mold_time @ESYudkowsky @turchin https://t.co/1kMjmeud5L https://t.co/Th3CPNsJ3u https://t.co/ewtnFCWLUb https://t.co/3tiGpdh7GL https://t.co/CORfmZhaI6 https://t.co/L0VMUer7Mb https://t.co/IecBqxPOJA https://t.co/rV2A8NgpYU https://t.co/ZPG8vm9O7m https://t.co/IlT1QHbkqv
@ValerieAnne1970 @SBakerMD @KenDBerryMD @anthony_chaffee @bigfatsurprise @drcateshanahan And feel free to include links, to educate fact checkers, like this: Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity - PMC (https://t.co/fKtXYDg7gu) :)
@TuckerGoodrich There's a lot of proof. PUFA makes you fat: https://t.co/hDK7588m7p
@nicknorwitz The D12492 diet has soybean oil, rich in omega-6 linoleic acid, which has been tied to obesity in mice. We don't know how the pigs were fed which supplied the lard, may be relevant; 2nd link. Is all this due to omega-6?
@LammingLab Obesity, NAFLD, glucose tolerance I suspect the butter group will do better than the PUFA group Something like this was done by Alvheim (https://t.co/QwbUIZ642J, https://t.co/tMhkQDJiEm) but would be cool to reproduce since you're so good at unobesing mice.
@cindybuckmaster @mz55qrf @mkenoyer @kevinfolta @TheNAIA Fair enough that you haven't heard of it. You may find this study from the @NIH informative. "Dietary linoleic acid elevates endogenous 2‐AG and anandamide and induces obesity" https://t.co/X8sBF0XU9E
@CaloriesProper https://t.co/GW6fd5RqX7
@agingdoc1 @BowTied_Ram Not if you just replace the seed oils with a saturated fat. Then there's no effect. The singular attribute of obesogenic diets is the consumption of seed oils. @NIH in @AJCNutrition : "Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity"
@BioLayne https://t.co/SWiRjyCum0
RT @fire_bottle: Pork sausage clocked in at 14.6% of calories from linoleic acid. 8% of calories from LA makes mice fat in the lab. You s…
RT @fire_bottle: Pork sausage clocked in at 14.6% of calories from linoleic acid. 8% of calories from LA makes mice fat in the lab. You s…
RT @fire_bottle: Pork sausage clocked in at 14.6% of calories from linoleic acid. 8% of calories from LA makes mice fat in the lab. You s…
Pork sausage clocked in at 14.6% of calories from linoleic acid. 8% of calories from LA makes mice fat in the lab. You still eating that high-PUFA pork for breakfast? https://t.co/Jxyde6hYxG https://t.co/QXvPkQdAbV
@Joe42773166 @robertlufkinmd https://t.co/6MIXTXXjwm https://t.co/ltzJWbwfJj https://t.co/FcmBfoaTl8
@lymanstoneky I'm not a doctor and I don't play one on tv. I think the answer is that some research suggests consuming linoleic acid, the fatty acid in seed oils, promotes obesity. Basically, the seed oils change your body composition. https://t.co/KeJQL6em42
Dietary Linoleic Acid (=seed oils) Elevates Endogenous 2-AG & Anandamide (=hyperactive endocannabinoid tone) and drives Obesity — Dietary LA increased tissue AA, and elevated 2-AG + 1-AG & AEA resulting in development of diet-induced obesity https://t.co/hS93jLRl4w #VegetableOils
O ácido linoleico dietético eleva o 2-AG endógeno e a anandamida e induz a #obesidade. https://t.co/qaqO29VvVn
RT @Mangan150: Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. O…
RT @Mangan150: Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. O…
RT @Mangan150: Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. O…
RT @Mangan150: Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. O…
Another way seed oils increase obesity is by increasing endogenous cannabinoids, which are made from omega-6 fatty acids. One might say they give you the munchies 24/7. https://t.co/ZFsh9U48eS
@asturias_paula Absolutely https://t.co/i1WlMwLJgu
RT @bruno_crocco: 9/16 How to elevate 2AG/Anandamide? "Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity…
9/16 How to elevate 2AG/Anandamide? "Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity." https://t.co/U9XYpQO4sE
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
RT @Mangan150: The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the o…
The only thing you need to do to make rats obese is feed them enough seed oils, and reducing seed oil content reverses the obesogenic effect https://t.co/vAYGUEwTPz
4/5 [Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity] https://t.co/8Dy90DMhRQ
RT @TuckerGoodrich: "...in human diets… substantially contributed to increasing prevalence rates of obesity.” "Dietary Linoleic Acid Eleva…
"...in human diets… substantially contributed to increasing prevalence rates of obesity.” "Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity. https://t.co/X8sBF0GiL4 For more: https://t.co/GK39XJaPjB #lcl6
@puddleg @DanielJDrucker @whsource @PNASNews ...in mice. If endogenous cannabinoids were a major determinant of human obesity, then fish oil supplementation would be slimming, as seen in Alvheim et al 2012. https://t.co/vWndZrnbdJ
Stop using seed oils https://t.co/qmWBBhJ7Wh
@mold_time @jeffnobbs Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity https://t.co/5ooi1EnNqt
@EAllen0417 1. The SFA content isn't even that high here. ~35 %FA (compare: butter is ~65 %FA). You can design high fat mouse diets with SFA up to 85 %FA that don't cause DIO. The factor is HUFA imbalance, not SFA content. https://t.co/vWndZrnbdJ
@Plant_proof @philedsphil @mosca_matthew @JohnG_UK @NutritionMadeS3 Fats may be equal in a bomb calorimeter but worth remembering they are different with respect to energy partitioning within animals https://t.co/J3NQXECCU3 https://t.co/6UyYPJWfXL
@FoodLiesOrg I agree with everything except calories in/calories out bs. Its been debunked. https://t.co/Y5ospTDGN3 The problem is hormones control and many peoples metabolism is now royally fucked from eating vegetable oils. Its an an infinite loop of trying to gain weight.
O ácido linoleico dietético aumentou o ácido graxo ω-6 araquidônico do tecido resultando no desenvolvimento de obesidade induzida pela dieta. #linoleicacid https://t.co/4TnA05QecM
RT @Mangan150: Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely…
RT @Mangan150: Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely…
RT @Mangan150: Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely…
RT @Mangan150: Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely…
Linoleic acid (from seed oils) elevates endocannabinoid tone to produce obesity. Increases of human LA consumption closely correlate with increasing prevalence rates of obesity. https://t.co/vAYGUEwTPz
@ArtirKel @AdamMarblestone https://t.co/Z6zrjLa3u0
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
This study examined the effects on weight gain by substituting linoleic acid, the main component of corn, soybean, sunflower and safflower oils, with SATURATED fat (coconut oil). The study: https://t.co/yf7fK1yl9c
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
RT @MatthewJDalby: This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets.…
This mouse study is used as evidence that seed oils (linoleic acid) causes obesity. It uses very well controlled diets. Mice eating 1% linoleic acid gained less fat than those eating 8%. But I found the results a bit odd so I thought I'd look into it. https://t.co/9GcvwauZKB https://t.co/eXdrQalmM9
RT @SolBrah: Study here: https://t.co/jiZEF3fq0H
RT @SolBrah: Study here: https://t.co/jiZEF3fq0H
RT @SolBrah: Study here: https://t.co/jiZEF3fq0H
RT @SolBrah: Study here: https://t.co/jiZEF3fq0H
Study here: https://t.co/jiZEF3fq0H
@foundmyfitness And does⬆️food reward translate to obesity later in life? Yes, in at least one murine model: Consuming a HFD w/⬆️linoleic acid from gestation until adulthood was a/w severe obesity, worse than from HFD alone: https://t.co/UtI963Umnr Another @foundmyfitness actionable win
@gerdosi @MarquisDeMarche @oztish @FatEmperor https://t.co/vGWj8bqGi7 "Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity"
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
RT @Mangan150: When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linole…
When given in amounts that approximate current human consumption, linoleic acid induces obesity. Greatest source of linoleic acid -> industrial seed oils. https://t.co/ZFsh9U48eS https://t.co/PA272Bzmku
@LoriShemek @KetoDocCLT @SatchinPanda It's not genetic. "The adipogenic effect of LA can be prevented by consuming sufficient EPA and DHA to reduce the AA-PL pool and normalize endocannabinoid tone. "Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity." https://t.co/g4JG3Exd5j
@erreyedoc @PeterFaberSP @RChrisCC @superbirdman1 @skyking171717 @Gearoidmuar @deniseminger @AnnChildersMD @DrEades Because the poultry and soy oils do track pretty well with obesity (REALLY well for poultry, the largest dietary source of LA) Doi:10.1038/oby.2012.38 - Carbs, meanwhile, don't really get a look in - are you LCHF guys sure you aren't tilting at the wrong windmill? https://t.co/7hBiMMmGaN
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