J Theor Biol May 2012 PMID 22342935

Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression.

Paul Macklin, Mary E Edgerton, Alastair M Thompson, Vittorio Cristini

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Peak: 8 in Jan 2022

across 2 sources since Oct 2010

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The discussion highlights recognition of the publication's importance, with remarks about its citation milestone and its role in advancing understanding through agent-based modeling, suggesting a tone of appreciation and reflection on its significance.

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Most discussions acknowledge the significance of the research, referencing its high citation count and scientific value.

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Posts show moderate interest, discussing past work and the relevance of modeling studies in cancer research.

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Posts demonstrate deep engagement by referencing a specific publication and its historical context, indicating thoughtful reflection.

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Discussions imply a positive impact by celebrating the paper's influence and potential implications for the field.

Abstract in brief

The study develops a detailed agent-based model of DCIS, a precursor to invasive breast cancer, incorporating cell behavior, biomechanics, and calcification, and calibrates it using patient-specific histopathology data.
The model simulates DCIS growth over 45 days, finding that necrotic cell death relieves stress and contributes to linear tumor expansion, with growth rates matching clinical data.
This research demonstrates how computational models can improve understanding of DCIS progression and potentially enhance treatment planning through better interpretation of imaging and pathology.]

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All mentions

Ductal carcinoma in situ (DCIS) simulation - extended results

Paul Macklin · Dec 20, 2010 11,453 views

Agent-Based Simulation of Ductal Carcinoma In Situ Growth and Progression

This simulation models 30 days of DCIS growth within a breast duct, calibrated with patient-specific histology data. It highlights necrotic cell death’s role in relieving stress and enabling linear tumor expansion…

Paul Macklin · Oct 27, 2010 6,627 views

Agent-Based Simulation of DCIS Growth and Boundary Stability

This video showcases a 30-day simulation of ductal carcinoma in situ growth, calibrated with patient-specific data. The model demonstrates how necrotic cell death relaxes stress and influences tumor expansion, aiding…

Paul Macklin · Oct 26, 2010 2,204 views

Agent-Based Simulation of DCIS Growth and Mechanics in Breast Cancer

Agent-based simulation of ductal carcinoma in situ (DCIS) models tumor growth constrained within breast ducts, calibrated to patient-specific data. The study examines cell adhesion, mechanics, and proliferation…

Paul Macklin · Dec 19, 2010 1,221 views