Mitochondrial protection and anti-aging activity of Astragalus polysaccharides and their potential mechanism.

Abstract in brief

• The study investigates the protective effects of Astragalus polysaccharides (APS) on mitochondria and its potential anti-aging activities, particularly how it counters lipid peroxidation in liver and brain mitochondria caused by Fe(2+)-Vit C.
• Methods like TBA colorimetry and spectrophotometry were used to measure oxidative damage and mitochondrial permeability, while APS demonstrated significant scavenging of harmful free radicals such as superoxide anion and hydroxyl radicals in a concentration-dependent manner.
• In vivo experiments using mice showed that APS could enhance the activity of key antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and inhibit damaging processes, indicating its potential