PubHawk
Endocr Rev June 2012 PMID 22419778

Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.

Laura N Vandenberg, Theo Colborn, Tyrone B Hayes, Jerrold J Heindel, David R Jacobs, Duk-Hee Lee, Toshi Shioda, Ana M Soto, Frederick S vom Saal, Wade V Welshons, R Thomas Zoeller, John Peterson Myers

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Mentions

108
Peak: 3 in May 2021
across 6 sources since Jan 2017

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AI synopsis

What people are saying

The discussions reflect a consensus that low-dose effects and nonmonotonic dose-responses are scientifically significant, exemplified by references to studies like Vandenberg et al., and critiques of outdated toxicology principles such as Paracelsus's 'dose makes the poison.' Words like 'eye-opening,' 'crucial,' and 'must change' underscore the perceived impact of the research, with many emphasizing the need for reform in testing and regulation.

AgreementStrong agreement

Most discussions strongly support the article's findings about low-dose effects and nonmonotonic responses in endocrine disruptors.

InterestHigh interest

Participants showcase high interest, referencing studies, scientific principles, and calling for regulatory changes, indicating they value the topic.

EngagementHigh engagement

Discussions involve detailed explanations, examples like Tamoxifen's dose-dependent effects, and references to scientific literature, demonstrating deep engagement.

ImpactHigh impact

Many posts argue for substantial scientific and regulatory re-evaluation, emphasizing the importance and urgency of understanding low-dose chemical effects on health.

Abstract in brief

  • This text explains how endocrine-disrupting chemicals (EDCs) can cause effects even at very low doses, challenging traditional toxicology that assumes higher doses are more harmful.
  • It introduces the concepts of low-dose effects, which happen around typical human exposure levels, and nonmonotonic dose-response curves, where the relationship between dose and effect isn't straightforward and can change direction within the dose range.
  • The authors argue that because low doses of EDCs can impact health and these effects are supported by scientific studies, new testing methods are necessary to better understand and protect human health from these chemicals.]
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Top posts

Most liked on X and Bluesky
Alzhacker
@Alzhacker · X

何十年もの間、内分泌かく乱化学物質（EDC）の研究は、毒性学における伝統的な概念、特に「用量が毒を作る」というドグマに挑戦してきた。 EDCへの環境暴露がヒトの疾患や障害と関連していることを疫学研究が示している。 https://t.co/0NXj2QDo32

Dec 10, 2023 · 9 likes · 1 share · 32,860 followers View post →
Pete Myers
@petemyers · X

1/2 @kevinfolta You clearly don’t understand non-monotonicity. Simple example. Tamoxifen is used to treat breast cancer. At high doses it suppresses tumor growth. At low doses, ~1000-fold beneath the NOEAL, it promotes tumor growth. Data in https://t.co/wz6D39JhjO https://t.co/NBsfsa8KS5

Aug 31, 2021 · 9 likes · 4 shares · 3,483 followers View post →
Alex Leaf
@AlexJLeaf · X

Rather, numerous experiments with chemicals that act via hormonal mechanisms have shown that it is very common for the dose-response curve to be non-monotonic and have notable health effects at low doses below current safety limits. 12/n https://t.co/bS8nSyZUZr https://t.co/6Ibv7dkSh2

Aug 22, 2020 · 5 likes · 4,034 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

The endocrine system has revealed U-shaped (nonmonotonic) and nonlinear exposure-response functions, as explained by @ElleEnvy https://t.co/SI4PQO94Dl 2/

May 7, 2021 · 4 likes · 1 share · 3,139 followers View post →
✯Vixen Valentino✯
@vixenvalentino · X

@ktibus @CaulfieldTim @thehill @unbiasedscipod @CropLifeAmerica Her entire article is based on a flawed assumption about toxicology. https://t.co/dT5DgEpYo3

Apr 2, 2024 · 4 likes · 1,258 followers View post →
Paul D. Thacker
@thackerpd · X

@tarahaelle @HomegrownJoan2 @vixenvalentino @IWF Ya' kinda' wanna' stop. Nobody but industry hacks cite Paracelsus and "dose makes the poison." https://t.co/VmRdpFDqH8

May 29, 2021 · 3 likes · 78,173 followers View post →

All mentions

狩りする家猫　Jagdcatzen
@RaidenShar · X

@TBDD_yahoo 環境ホルモン≒ホルモンかく乱物質に関しては最近いくつも査読付き論文がでていますが、当然TBDD(モデルナ4回接種済)様に置かれましてはご承知の事と思います 　念の為レスしておきますね① Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses https://t.co/EYNYR1VCcH

Oct 1, 2025 · 329 followers View post →
MCAlexius
@MCAlexius · X

@henningAEO @jeremyfromga @MeidasTouch The study the German Wiki quotes ("Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses" L. N. Vandenberg, T. Colborn, T. B. Hayes et al) is also reference on English Wiki, which includes additional sources that 1/

Jan 30, 2025 · 17 followers View post →
✯Vixen Valentino✯
@vixenvalentino · X

@ktibus @CaulfieldTim @thehill @unbiasedscipod @CropLifeAmerica Her entire article is based on a flawed assumption about toxicology. https://t.co/dT5DgEpYo3

Apr 2, 2024 · 4 likes · 1,258 followers View post →
佐藤
@gp32er · X

RT @Alzhacker: 何十年もの間、内分泌かく乱化学物質（EDC）の研究は、毒性学における伝統的な概念、特に「用量が毒を作る」というドグマに挑戦してきた。 EDCへの環境暴露がヒトの疾患や障害と関連していることを疫学研究が示している。 https://t.co/0NXj…

Dec 10, 2023 · 1 share · 497 followers View post →
Alzhacker
@Alzhacker · X

何十年もの間、内分泌かく乱化学物質（EDC）の研究は、毒性学における伝統的な概念、特に「用量が毒を作る」というドグマに挑戦してきた。 EDCへの環境暴露がヒトの疾患や障害と関連していることを疫学研究が示している。 https://t.co/0NXj2QDo32

Dec 10, 2023 · 9 likes · 1 share · 32,860 followers View post →
Nihilo Nostrum
@NihiloNostrum · X

"We conclude that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses. Thus, fundamental changes in chemical testing and safety determination are needed to protect human health." -https://t.co/zfVCleWWAl

Jul 8, 2023 · 1 like · 432 followers View post →
Monsanto Tribunal
@monsantotribun · X

@RizziEmmanuel @GreensEFA @AssoPollinis @wienerofficial @gruffat_claude @RipaManuela @galleerie @DamienCAREME @rosadamato634 @msaraswati @JuttaPaulusRLP @FGuerreiroMEP @ph_lamberts That's an old myth. Not for endocrine disruptors. #EDCs https://t.co/OChAAvfBIH

Oct 26, 2022 · 4,205 followers View post →
BobPH
@bob_ph · X

@Thoughtscapism @jm_desp @TreeFarmerBC @scarlenn @UusivuoriVille @agowa338 The first article cited is actually excellent and should be read. But generally, regulators are only starting to look at this. And looking at in vivo experiments with obesogens is eye opening and very significant, contrary to what your articles concludes https://t.co/UUvbEpI7u0

May 5, 2022 · 2 followers View post →
RedFrog
@_RedFrog · X

RT @petemyers: 1/2 @kevinfolta You clearly don’t understand non-monotonicity. Simple example. Tamoxifen is used to treat breast cancer. A…

Aug 31, 2021 · 4 shares · 3,826 followers View post →
✯Vixen Valentino✯
@vixenvalentino · X

RT @petemyers: 1/2 @kevinfolta You clearly don’t understand non-monotonicity. Simple example. Tamoxifen is used to treat breast cancer. A…

Aug 31, 2021 · 4 shares · 1,258 followers View post →
Pete Myers
@petemyers · X

1/2 @kevinfolta You clearly don’t understand non-monotonicity. Simple example. Tamoxifen is used to treat breast cancer. At high doses it suppresses tumor growth. At low doses, ~1000-fold beneath the NOEAL, it promotes tumor growth. Data in https://t.co/wz6D39JhjO https://t.co/NBsfsa8KS5

Aug 31, 2021 · 9 likes · 4 shares · 3,483 followers View post →
Paul D. Thacker
@thackerpd · X

@tarahaelle @HomegrownJoan2 @vixenvalentino @IWF Ya' kinda' wanna' stop. Nobody but industry hacks cite Paracelsus and "dose makes the poison." https://t.co/VmRdpFDqH8

May 29, 2021 · 3 likes · 78,173 followers View post →
Paul D. Thacker
@thackerpd · X

RT @leotrasande: The endocrine system has revealed U-shaped (nonmonotonic) and nonlinear exposure-response functions, as explained by @Elle…

May 8, 2021 · 1 share · 78,173 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

The endocrine system has revealed U-shaped (nonmonotonic) and nonlinear exposure-response functions, as explained by @ElleEnvy https://t.co/SI4PQO94Dl 2/

May 7, 2021 · 4 likes · 1 share · 3,139 followers View post →
Silahammer 4k
@SekretSila · X

https://t.co/Kvr0sElnCn

Apr 5, 2021 · 4,419 followers View post →
Marx_&_Smith
@sageliberal · X

@MacLesggy je vous invite à revoir vos postulats qui datent un peu (paracelse) et lire L. Vandeberg : "Hormones and endocrine-disrupting chemicals : Low-dose effects and nonmonotonic dose responses"

Mar 9, 2021 · 305 followers View post →
Alex Leaf
@AlexJLeaf · X

Rather, numerous experiments with chemicals that act via hormonal mechanisms have shown that it is very common for the dose-response curve to be non-monotonic and have notable health effects at low doses below current safety limits. 12/n https://t.co/bS8nSyZUZr https://t.co/6Ibv7dkSh2

Aug 22, 2020 · 5 likes · 4,034 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

@AviBittMD I appreciate you were taught Paracelsian toxicology: “only the dose makes something a poison.” Times and science have changed much since then. Little things matter. Dismissing small changes in exposure as minuscule is scientifically inaccurate. https://t.co/SI4PQNRteL

Jul 10, 2020 · 3,139 followers View post →
Nastaran PGH
@NastaranPgh · X

https://t.co/83vr7WxMAP https://t.co/yqSA5Ioru5

Dec 14, 2019 · 20 followers View post →
Pete Myers
@petemyers · X

@MSteilemann We met w FDA before publishing this paper https://t.co/CAaNDrqIR4 The scientist I met with said "We don't see patterns like that." I said "Of course not. You don't test those low doses." She said: "Oh, you're right." Now she works for product defense company, earns 10x FDA salary

Apr 20, 2019 · 3,483 followers View post →
Yes Kamala Harris is Thee Vice President
@justice_healing · X

@ehn Sigh. Wow so that's you, huh? Vandenberg et al. (2012). Hormones and Endocrine Disrupting Chemicals: Low-dose Effects and Nonmonotonic Dose Responses. Endocrine Reviews. First published ahead of print March 14, 2012 as doi:10.1210/er.2011-1050

Apr 16, 2019 · 1,255 followers View post →