PubHawk
PLoS One October 2012 PMID 22506074

Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.

Hua V Lin, Andrea Frassetto, Edward J Kowalik, Andrea R Nawrocki, Mofei M Lu, Jennifer R Kosinski, James A Hubert, Daphne Szeto, Xiaorui Yao, Gail Forrest, Donald J Marsh

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Mentions

21
Peak: 5 in Oct 2025
across 6 sources since Jun 2017

Extended reach

20,457
potential audience

Total likes

52

Video views

1,313

Mentions per month

Jun 2017 – Nov 2025

Where it's discussed

  • TikTok8 posts
  • X / Twitter4 posts
  • Reddit3 posts
  • News3 articles
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  • Instagram1 posts

AI synopsis

What people are saying

Discussions emphasize the significance of gut microbiome health and SCFAs in preventing obesity and diabetes, with language like 'protects against' and 'regulates hormones' indicating positive reception. The tone is focused on health benefits and potential for improved treatments, which conveys a generally optimistic view of the research without dramatic language.

AgreementModerate agreement

Most discussions express agreement with the importance of SCFAs, highlighting their protective role against obesity and diabetes, thus showing general support for the research findings.

InterestHigh interest

Posts indicate a high level of curiosity about gut health and the mechanisms behind metabolic regulation, reflecting strong interest.

EngagementModerate engagement

Comments acknowledge the details of the research and its implications, though not all delve deeply into mechanisms, resulting in moderate engagement.

ImpactModerate impact

The emphasis on the potential health benefits and the call for increased awareness suggest a noticeable but not transformative perceived impact.

Abstract in brief

  • Short-chain fatty acids like butyrate, propionate, and acetate help protect against weight gain and improve insulin sensitivity, but they do so in ways that don't solely rely on the known receptor FFAR3.
  • While butyrate and propionate boost gut hormone production and decrease food intake, these effects occur even without FFAR3, indicating alternative pathways are involved.
  • This research suggests that gut microbiota influences host metabolism through multiple mechanisms, not just via FFAR3, highlighting the complexity of how dietary fibers and their fermentation products affect health.]
Read the full abstract

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Most liked on X and Bluesky
やまだ@腸活×アンチエイジング
@tarou_ymd_ · X

筆者たちは、

Aug 27, 2023 · 4 likes · 9,587 followers View post →
For health-promoting environments
@SilkeLeFay · X

#publichealth #generalpractice #inflammasome #SCFAs #health #diabetes #cardiovascular #inflammasome #aging Gut microbiome health with adequate production of short-chain fatty acids (SCFAs) butyrate and propionate protects against obesity and diabetes . https://t.co/m3IqjjYPoz

Dec 24, 2022 · 1 like · 4,580 followers View post →
For health-promoting environments
@SilkeLeFay · X

#GLP1 #semaglutide #weightloss #globalhealth #primaryhealthcare #ozempic #diabetes #diabetes #obesity #health Gut microbiome health with adequate production of short-chain fatty acids (SCFAs) butyrate and propionate protects against obesity and diabetes . https://t.co/m3IqjjYPoz https://t.co/VD7drWhqXm

Nov 20, 2022 · 4,580 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms https://t.co/LMkVBVUb4O

Nov 22, 2021 · 248 followers View post →

All mentions

やまだ@腸活×アンチエイジング
@tarou_ymd_ · X

筆者たちは、

Aug 27, 2023 · 4 likes · 9,587 followers View post →
For health-promoting environments
@SilkeLeFay · X

#publichealth #generalpractice #inflammasome #SCFAs #health #diabetes #cardiovascular #inflammasome #aging Gut microbiome health with adequate production of short-chain fatty acids (SCFAs) butyrate and propionate protects against obesity and diabetes . https://t.co/m3IqjjYPoz

Dec 24, 2022 · 1 like · 4,580 followers View post →
For health-promoting environments
@SilkeLeFay · X

#GLP1 #semaglutide #weightloss #globalhealth #primaryhealthcare #ozempic #diabetes #diabetes #obesity #health Gut microbiome health with adequate production of short-chain fatty acids (SCFAs) butyrate and propionate protects against obesity and diabetes . https://t.co/m3IqjjYPoz https://t.co/VD7drWhqXm

Nov 20, 2022 · 4,580 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms https://t.co/LMkVBVUb4O

Nov 22, 2021 · 248 followers View post →
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