J Clin Endocrinol Metab July 2012 PMID 22535969

Metabolic slowing with massive weight loss despite preservation of fat-free mass.

Darcy L Johannsen, Nicolas D Knuth, Robert Huizenga, Jennifer C Rood, Eric Ravussin, Kevin D Hall

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Mentions

144
Peak: 6 in Nov 2020
across 6 sources since May 2020

Extended reach

121,300
potential audience

Total likes

1,414

Video views

59,762

Mentions per month

May 2020 – Jun 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect a strong interest in understanding how metabolic slowing occurs despite efforts to preserve muscle, as shown by comments analyzing study data, and calling for careful weight management strategies. The tone varies from scientific to casual, with examples like references to specific figures in the research and advice on controlling carb intake, illustrating how the publication sparks both curiosity and practical considerations among readers.

AgreementModerate agreement

Most discussions recognize the study's findings that metabolic slowdown occurs despite fat-free mass preservation, aligning with the article's conclusions.

InterestHigh interest

There is high curiosity and engagement around topics like how weight loss affects metabolism and muscle loss, reflected in questions about strategies and implications.

EngagementModerate engagement

Several posts delve into detailed analysis, referencing specific data, studies, and practical advice, indicating a moderate level of deep engagement.

ImpactModerate impact

The discussions suggest the research influences opinions about dieting, weight management, and understanding human metabolism, hinting at some influence in the community.

Abstract in brief

  • During a weight loss program involving diet restriction and vigorous exercise, participants experienced significant weight loss primarily from fat, but also lost some fat-free mass (FFM), and their resting metabolic rate (RMR) declined more than expected based on the weight lost, indicating a metabolic slowdown or adaptation.
  • Despite increasing physical activity levels, the decline in RMR was not prevented, meaning the body's metabolism slowed down substantially even with effort, which could make it harder to maintain weight loss over time.
  • This metabolic adaptation might persist during weight maintenance, potentially leading to weight regain unless individuals continue high levels of physical activity or caloric restriction.]

Top posts

Most liked on X and Bluesky
Octópodo
@Jappy_octopus · X

Hoy vamos con un hilo muy importante a la hora de calcular nuestro máximo déficit posible sin perder masa muscular, para ello nos basaremos en los siguientes estudios: https://t.co/07b957kirr https://t.co/Dy0J9GA2F2 https://t.co/mk9lHqixCr

Nov 3, 2020 · 16 likes · 3 shares · 1,764 followers View post →
junglehoney
@KruseYouri · X

"Despite relative preservation of FFM, exercise did not prevent dramatic slowing of resting metabolism out of proportion to weight loss." https://t.co/56WV8XM2jp

Dec 7, 2022 · 6 likes · 12,797 followers View post →
thalesnemo
@thalesnemo · X

@saaiyer No not really . Control the CARBS below one’s own threshold EAT to SATIETY and the weight comes off without effort . https://t.co/VJdN53Yxd1➡️ https://t.co/XyQkkwCaU8➡️ https://t.co/uc54dlRBl3 ➡️ https://t.co/MmKm7XG2NC

Jun 11, 2022 · 5 likes · 1,114 followers View post →
Dani Trainer
@Dani_trainer_ · X

Otro problema de las dietas es que en los cambios de peso drásticos se pierde grasa sí, pero también músculo. Cuando la persona deja la dieta, recupera peso solo de grasa, lo que genera una situación metabólica desastrosa. https://t.co/U1nFxgV4zM

Jul 7, 2023 · 1 like · 18,445 followers View post →
Nick Krontiris
@nick_krontiris · X

"...That is not the case... In fact, the evidence suggests metabolic adaptation to be a reflection of the magnitude of weight loss: the larger the weight loss, the larger the metabolic adaptation refs: https://t.co/CGexeBVvbO https://t.co/jJWlzvOTns https://t.co/L97jy3PR9C

May 12, 2020 · 1 share · 18,966 followers View post →
Fuji3@retired
@Fuji3_R6 · X

長期のカロリー制限でやせなくなるのは「代謝の大幅な減少」が原因。それを引き起こすのが ①甲状腺ホルモンが減る ②脳が体にエネルギー節約命令を出す ①甲状腺ホルモンは代謝をコントロールするホルモンであり、減ると基礎代謝が大きく落ちていく(=脂肪が燃えない) https://t.co/225jdP6UFV

Jun 22, 2021 · 3,578 followers View post →

All mentions

Raymond Moore
@RayMooreII · X

@claud334 @JohnnyBlack_HS @ClickingSeason Johannsen et al. (2012) - "Metabolic Slowing with Massive Weight Loss despite Preservation of Fat-Free Mass" Citation: J Clin Endocrinol Metab. 2012 Jul;97(7):2489–2496. doi:10.1210/jc.2012-1444. Summary: This study examined metabolic changes in participants undergoing

Jun 7, 2025 · 630 followers View post →
Falant
@Falkenby · X

@catsiesxx @9mm_smg Even the studies in that article say that you are wrong. See "week 30" in fat loss plot. Just take the L m8 it's OK to be wrong on ther internet https://t.co/LKAg826JAC

Oct 16, 2023 · 197 followers View post →
Dani Trainer
@Dani_trainer_ · X

Otro problema de las dietas es que en los cambios de peso drásticos se pierde grasa sí, pero también músculo. Cuando la persona deja la dieta, recupera peso solo de grasa, lo que genera una situación metabólica desastrosa. https://t.co/U1nFxgV4zM

Jul 7, 2023 · 1 like · 18,445 followers View post →
junglehoney
@KruseYouri · X

"Despite relative preservation of FFM, exercise did not prevent dramatic slowing of resting metabolism out of proportion to weight loss." https://t.co/56WV8XM2jp

Dec 7, 2022 · 6 likes · 12,797 followers View post →
thalesnemo
@thalesnemo · X

@saaiyer No not really . Control the CARBS below one’s own threshold EAT to SATIETY and the weight comes off without effort . https://t.co/VJdN53Yxd1➡️ https://t.co/XyQkkwCaU8➡️ https://t.co/uc54dlRBl3 ➡️ https://t.co/MmKm7XG2NC

Jun 11, 2022 · 5 likes · 1,114 followers View post →
ol
@ol63056113 · X

https://t.co/rW3nSuK440

Sep 16, 2021 · 30 followers View post →
Fuji3@retired
@Fuji3_R6 · X

長期のカロリー制限でやせなくなるのは「代謝の大幅な減少」が原因。それを引き起こすのが ①甲状腺ホルモンが減る ②脳が体にエネルギー節約命令を出す ①甲状腺ホルモンは代謝をコントロールするホルモンであり、減ると基礎代謝が大きく落ちていく(=脂肪が燃えない) https://t.co/225jdP6UFV

Jun 22, 2021 · 3,578 followers View post →
thalesnemo
@thalesnemo · X

RT @thalesnemo: @Shane_of_AZ @BioLayne @mosca_matthew @The_Nutrivore The floor is open 1️⃣ https://t.co/XyQkkwkA2A 2️⃣ https://t.co/uc54dm9…

Jun 18, 2021 · 1 share · 1,114 followers View post →
thalesnemo
@thalesnemo · X

@Shane_of_AZ @BioLayne @mosca_matthew @The_Nutrivore The floor is open 1️⃣ https://t.co/XyQkkwkA2A 2️⃣ https://t.co/uc54dm9cJD 3️⃣ https://t.co/MmKm7XXEcc 4️⃣ https://t.co/FLdgAzejSQ 5️⃣ https://t.co/VH2vHXVijz 6️⃣ https://t.co/xV7kpSwo1J 7️⃣ https://t.co/h3NUgkww0w 8️⃣ https://t.co/bgLMxgYVqQ

Jun 18, 2021 · 1 share · 1,114 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @nick_krontiris: "...That is not the case... In fact, the evidence suggests metabolic adaptation to be a reflection of the magnitude of…

Nov 22, 2020 · 1 share · 1,375 followers View post →
FULL ON LIFE
@FullonLife2 · X

https://t.co/ffQJUns9z3 https://t.co/vqQjnqFIn8

Nov 22, 2020 · 9 followers View post →
claimshero.eth
@claimshero__eth · X

RT @Jappy_octopus: Hoy vamos con un hilo muy importante a la hora de calcular nuestro máximo déficit posible sin perder masa muscular, para…

Nov 3, 2020 · 3 shares · 128 followers View post →
Guillem Vizcaíno
@vizcaphysiology · X

RT @Jappy_octopus: Hoy vamos con un hilo muy importante a la hora de calcular nuestro máximo déficit posible sin perder masa muscular, para…

Nov 3, 2020 · 3 shares · 193 followers View post →
David
@toreto2804 · X

RT @Jappy_octopus: Hoy vamos con un hilo muy importante a la hora de calcular nuestro máximo déficit posible sin perder masa muscular, para…

Nov 3, 2020 · 3 shares · 55 followers View post →
Octópodo
@Jappy_octopus · X

Hoy vamos con un hilo muy importante a la hora de calcular nuestro máximo déficit posible sin perder masa muscular, para ello nos basaremos en los siguientes estudios: https://t.co/07b957kirr https://t.co/Dy0J9GA2F2 https://t.co/mk9lHqixCr

Nov 3, 2020 · 16 likes · 3 shares · 1,764 followers View post →
Nick Krontiris
@nick_krontiris · X

"...That is not the case... In fact, the evidence suggests metabolic adaptation to be a reflection of the magnitude of weight loss: the larger the weight loss, the larger the metabolic adaptation refs: https://t.co/CGexeBVvbO https://t.co/jJWlzvOTns https://t.co/L97jy3PR9C

May 12, 2020 · 1 share · 18,966 followers View post →