May 2012 PMID 22539783

Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study.

Sarah Parish, Alison Offer, Robert Clarke, Jemma C Hopewell, Michael R Hill, James D Otvos, Jane Armitage, Rory Collins

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Mentions

13
Peak: 3 in Sep 2023
across 3 sources since Apr 2023

Extended reach

205,264
potential audience

Total likes

1,919

Video views

71,273

Mentions per month

Apr 2023 – Oct 2025

Where it's discussed

  • X / Twitter7 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

Examples such as mentions of the study's finding that LDL particle number is a strong predictor, and debates over the relevance of particle size versus count, demonstrate an engaged discussion about the nuances in lipid research. The tone balances scholarly critique with curiosity, reflecting a thoughtful engagement with the article's findings and their implications for understanding cardiovascular risk.

AgreementModerate agreement

Most discussions acknowledge the study's findings, with some skepticism about traditional lipid markers, indicating general agreement but room for alternative interpretations.

InterestModerate interest

Participants show moderate curiosity, discussing complex factors like particle size and counts, but do not deeply explore broader implications.

EngagementModerate engagement

The exchanges include references to specific research details and critiques, suggesting moderate investment in understanding the nuances.

ImpactModerate impact

The discussion highlights relevance for lipidology, with some considering its implications for future research and treatment strategies, indicating a modest level of perceived impact.

Abstract in brief

  • The study found that both cholesterol levels (like LDL and non-HDL) and lipoprotein particle concentrations are strongly linked to major coronary events, with LDL particle number being a particularly strong predictor.
  • Associations between these lipid measures and stroke or other cardiac events, such as heart failure, were weak or non-existent, indicating they are more specific to coronary occlusive events.
  • After adjusting for LDL particle number, HDL cholesterol and HDL particle number showed an inverse relationship with coronary events, but these measures were weakly associated with other cardiac issues, suggesting different lipid factors may influence various vascular events differently.

Top posts

Most liked on X and Bluesky
Thomas Dayspring
@Drlipid · X

@ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they found--- Given the total LDL particle number, the distribution between small and large particles DID NOT ADD predictive value See - https://t.co/V5ceujVscx https://t.co/SaVsOxKvqU

Sep 14, 2023 · 4 likes · 2 shares · 43,196 followers View post →
Mind Muscle Project
@mindmusclepro · X

https://t.co/7cM9cqfGx3

Jul 20, 2025 · 3 likes · 25,853 followers View post →
Mind Muscle Project
@mindmusclepro · X

@MANSAFAB https://t.co/7cM9cqfGx3 Tg/HDL is perhaps more relevant when LDL is low/normal. When LDL is high, this number may not add extra insight.

Oct 18, 2025 · 25,853 followers View post →
Mind Muscle Project
@mindmusclepro · X

@grok @ScottAppliedSci Why do they ignore papers such as these that say Particle size is less relevant when particle count is high https://t.co/7cM9cqfGx3 https://t.co/F88vsWiW7X

Sep 7, 2025 · 25,853 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

RT @Drlipid: @ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they foun…

Sep 20, 2023 · 2 shares · 12,858 followers View post →
Dr.Virk
@DrOLMC · X

RT @Drlipid: @ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they foun…

Sep 21, 2023 · 2 shares · 257 followers View post →

All mentions

Mind Muscle Project
@mindmusclepro · X

@MANSAFAB https://t.co/7cM9cqfGx3 Tg/HDL is perhaps more relevant when LDL is low/normal. When LDL is high, this number may not add extra insight.

Oct 18, 2025 · 25,853 followers View post →
Mind Muscle Project
@mindmusclepro · X

@grok @ScottAppliedSci Why do they ignore papers such as these that say Particle size is less relevant when particle count is high https://t.co/7cM9cqfGx3 https://t.co/F88vsWiW7X

Sep 7, 2025 · 25,853 followers View post →
Mind Muscle Project
@mindmusclepro · X

https://t.co/7cM9cqfGx3

Jul 20, 2025 · 3 likes · 25,853 followers View post →
Dr.Virk
@DrOLMC · X

RT @Drlipid: @ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they foun…

Sep 21, 2023 · 2 shares · 257 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

RT @Drlipid: @ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they foun…

Sep 20, 2023 · 2 shares · 12,858 followers View post →
Thomas Dayspring
@Drlipid · X

@ikunkkimoo That would take a textbook of lipidology - In a major analysis of the giant Heart Protection Study (HPS) they found--- Given the total LDL particle number, the distribution between small and large particles DID NOT ADD predictive value See - https://t.co/V5ceujVscx https://t.co/SaVsOxKvqU

Sep 14, 2023 · 4 likes · 2 shares · 43,196 followers View post →
健康ノート
@JuStADOcToR_Jp · X

Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study - PubMed https://t.co/M7gW3F8kBO

Apr 4, 2023 · 110 followers View post →