PubHawk
May 2012 PMID 22547799

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Heehyoung Lee, Peng Zhang, Andreas Herrmann, Chunmei Yang, Hong Xin, Zhenghe Wang, Dave S B Hoon, Stephen J Forman, Richard Jove, Arthur D Riggs, Hua Yu

Full text PDF Download social card

Mentions

3
Peak: 1 in Mar 2022
across 2 sources since Mar 2022

Extended reach

2,359
potential audience

Total likes

9

Video views

1,046

Mentions per month

Mar 2022 – Jan 2023

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Most comments express agreement with the research, emphasizing its potential relevance for cancer treatment strategies, with phrases like 'confirmation' and 'crucial role' indicating acknowledgment of its importance. The tone and context suggest an engaged audience interested in the molecular mechanisms and therapeutic implications of the findings.

AgreementModerate agreement

Posters generally agree with the findings, emphasizing the importance of acetylated STAT3 in gene methylation and how resveratrol can reverse this process.

InterestModerate interest

Discussions show moderate interest, with some posters highlighting the potential for cancer treatment and the mechanisms involved.

EngagementModerate engagement

Comments include references to experimental confirmation and implications for future therapies, indicating a moderate level of detailed discussion.

ImpactModerate impact

Participants recognize the significance of these findings for cancer research, suggesting a potentially high impact on understanding tumor suppression.

Abstract in brief

  • Acetylated STAT3 plays a key role in promoting hypermethylation of tumor suppressor gene promoters in cancer, and inhibiting this acetylation with resveratrol leads to demethylation and gene reactivation.
  • Modifying STAT3 at Lys685 reduces tumor growth by disrupting its interaction with DNA methyltransferase 1 (DNMT1), resulting in decreased methylation of tumor suppressor genes, and this effect is confirmed with an acetylation inhibitor, resveratrol.
  • These findings suggest that STAT3 acetylation influences DNA methylation patterns, including the methylation of estrogen receptor genes in breast cancer and melanoma, highlighting a potential target for cancer prevention and treatment strategies.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Woody Nist
@Woodynist · X

@adeolRxxxx @RubenQC_Lab Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation | PNAS "These observations are confirmed by treatment with an acetylation inhibitor, resveratrol" . https://t.co/r3OceU2TWM

Aug 17, 2022 · 1 like · 1,314 followers View post →

All mentions

Woody Nist
@Woodynist · X

@adeolRxxxx @RubenQC_Lab Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation | PNAS "These observations are confirmed by treatment with an acetylation inhibitor, resveratrol" . https://t.co/r3OceU2TWM

Aug 17, 2022 · 1 like · 1,314 followers View post →