Am J Clin Nutr June 2012 PMID 22552031

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis.

Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppönen, Jacqueline Berry, Reinhold Vieth, Susan Lanham-New

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Mentions

187
Peak: 14 in Feb 2023
across 5 sources since Aug 2019

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Aug 2019 – Oct 2025

Where it's discussed

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AI synopsis

What people are saying

Discussions highlight that vitamin D3 is more effective in increasing serum vitamin D levels, with posts emphasizing its biological role as a hormone and recommending D3 supplements for better health, which underscores broad interest in practical health benefits. The tone is informative, with words like 'more effective' and 'significantly increases' stressing the significance of the research, but overall impact on policy or medical practices appears moderate.

AgreementModerate agreement

Many discussions affirm the finding that vitamin D3 is more effective than D2 at raising serum levels, as seen in phrases like 'Vitamin D3 is more effective' and 'D3 significantly increases serum vitamin D levels.'

InterestHigh interest

Several posts show curiosity about the biological roles of vitamin D, with comments highlighting its importance for the immune system and bone health, indicating active engagement with the topic.

EngagementHigh engagement

Participants reference specific facts, such as D3 being a hormone and more effective in raising serum levels, with some recommending it directly, demonstrating deeper understanding and application of the research findings.

ImpactModerate impact

While discussions acknowledge D3's superior efficacy, they tend to focus on personal health advice or basic knowledge rather than broader societal or medical policy impacts, suggesting a moderate perceived relevance.

Abstract in brief

  • The study is a systematic review and meta-analysis comparing the effects of vitamin D2 and D3 on increasing serum 25-hydroxyvitamin D levels, and it found that vitamin D3 is more effective at raising these levels than vitamin D2.
  • Supplementing with vitamin D3, especially when given as a single large dose (bolus), significantly increases serum vitamin D levels compared to vitamin D2, although this difference is not seen with daily dosing.
  • The results suggest that vitamin D3 might be the preferred supplement for boosting vitamin D levels, but more research is needed to understand how it works in different populations, and through various administration methods.

Top posts

Most liked on X and Bluesky
William B. Grant, PhD
@wbgrant2 · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://t.co/gXjJ1llJOe

Feb 21, 2023 · 35 likes · 11 shares · 6,106 followers View post →
Lily | Workoutfrolic
@WorkoutFrolic · X

5/ Vitamin D supplements come in two forms: - Ergocalciferol (Vitamin D2) - Cholecalciferol (Vitamin D3). When choosing a supplement, aim for one containing cholecalciferol (D3), as it is more effective in improving your Vitamin D levels. https://t.co/dFPTBEZRxM

Jan 1, 2022 · 10 likes · 1 share · 8,135 followers View post →
William B. Grant, PhD
@wbgrant2 · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://t.co/gXjJ1l3AA6

Aug 25, 2020 · 9 likes · 3 shares · 6,106 followers View post →
Dr Pooja Garg
@poojagarg1111 · X

https://t.co/mhrQNkke6q

Feb 14, 2023 · 7 likes · 1 share · 27,983 followers View post →
Valerie, RD, MPH
@RDValerie · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis https://t.co/4sxN4xzgnH https://t.co/jXT5sKuvx7

Aug 19, 2019 · 5 likes · 2 shares · 34,123 followers View post →
Marcin Lignowski MSc
@_RadicalHealth_ · X

@quiltdungeon @theproof I think vit. D2 is cheaper to produce, this is why it is used in fortified foods and cheap multivitamins. It is also less effective at raising serum levels of vit. D. D3 is the form produced by animals (incl. humans). https://t.co/7Pz47ZhA90

May 7, 2023 · 4 likes · 25 followers View post →

All mentions

OK MAGA Mama ⛪️
@RWOKMAGARN · X

RT @TakeWeightOffMD: @KSinNE @MakisMD Great question. Many people forget Vitamin D3 is a nuclear cell signaling molecule and technically a…

Sep 12, 2023 · 1 share · 1,335 followers View post →
Dr Murphy WeightLoss
@TakeWeightOffMD · X

@KSinNE @MakisMD Great question. Many people forget Vitamin D3 is a nuclear cell signaling molecule and technically a hormone. https://t.co/kJ0mRsf0CE Levels are a rough proxy of its effect. If it’s low it’s bad, if it’s too high it can be bad. Taking exogenous in any level helps with the

Sep 10, 2023 · 1 like · 1 share · 6,789 followers View post →
Marcin Lignowski MSc
@_RadicalHealth_ · X

@quiltdungeon @theproof I think vit. D2 is cheaper to produce, this is why it is used in fortified foods and cheap multivitamins. It is also less effective at raising serum levels of vit. D. D3 is the form produced by animals (incl. humans). https://t.co/7Pz47ZhA90

May 7, 2023 · 4 likes · 25 followers View post →
Fundación Iberoamericana de Nutrición
@FinutOrg · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 22, 2023 · 11 shares · 4,043 followers View post →
KayLKelley
@KayLKelley · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 705 followers View post →
Brent Erickson
@BErickson_BIO · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 4,251 followers View post →
Imperator of Antarctica
@IndolentCoward · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 255 followers View post →
Kim Climer
@RhetoricalGirl0 · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 3,330 followers View post →
Nutrióloga Jessica Pérez
@nutriJesssica · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 765 followers View post →
luis alberto malaga
@malaga1711 · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 1,599 followers View post →
Sagittarius
@guani_vic · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 677 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 551 followers View post →
Paco Tarazona
@Sabater71 · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 1,217 followers View post →
CCSは誘発地震を起こす可能性ある
@MD_PhD_ivermect · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Feb 21, 2023 · 11 shares · 4,614 followers View post →
William B. Grant, PhD
@wbgrant2 · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://t.co/gXjJ1llJOe

Feb 21, 2023 · 35 likes · 11 shares · 6,106 followers View post →
Catherine
@CatherineLeaker · X

RT @poojagarg1111: https://t.co/mhrQNkke6q

Feb 15, 2023 · 1 share · 417 followers View post →
Dr Pooja Garg
@poojagarg1111 · X

https://t.co/mhrQNkke6q

Feb 14, 2023 · 7 likes · 1 share · 27,983 followers View post →
Nautil
@NautilHealth · X

Vitamin D is important for the immune system and strong bones. There are two forms - Vitamin D2 & D3. While both forms are absorbed equally, studies show that D3 is more effective in raising vitamin D levels in the blood. https://t.co/BWtB0a6ZeO

Dec 28, 2022 · 1 like · 18 followers View post →
Lily | Workoutfrolic
@WorkoutFrolic · X

RT @WorkoutFrolic: 5/ Vitamin D supplements come in two forms: - Ergocalciferol (Vitamin D2) - Cholecalciferol (Vitamin D3). When choos…

Jan 2, 2022 · 1 share · 8,135 followers View post →
Lily | Workoutfrolic
@WorkoutFrolic · X

5/ Vitamin D supplements come in two forms: - Ergocalciferol (Vitamin D2) - Cholecalciferol (Vitamin D3). When choosing a supplement, aim for one containing cholecalciferol (D3), as it is more effective in improving your Vitamin D levels. https://t.co/dFPTBEZRxM

Jan 1, 2022 · 10 likes · 1 share · 8,135 followers View post →
jack1225
@jack12251 · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis https://t.co/MFyaV36j9f

Sep 2, 2020 · 25 followers View post →
Pattibe
@pattiber1 · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Aug 25, 2020 · 3 shares · 780 followers View post →
Joaquín San José
@jsanjosea · X

RT @wbgrant2: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://…

Aug 25, 2020 · 3 shares · 409 followers View post →
William B. Grant, PhD
@wbgrant2 · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic r… https://t.co/gXjJ1l3AA6

Aug 25, 2020 · 9 likes · 3 shares · 6,106 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @RDValerie: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and…

Aug 19, 2019 · 2 shares · 6,709 followers View post →
AKA_Sadrien
@AKA_Sadrien · X

RT @RDValerie: Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and…

Aug 19, 2019 · 2 shares · 792 followers View post →
Valerie, RD, MPH
@RDValerie · X

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis https://t.co/4sxN4xzgnH https://t.co/jXT5sKuvx7

Aug 19, 2019 · 5 likes · 2 shares · 34,123 followers View post →