Am J Psychiatry September 2012 PMID 22864465

A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder.

In Kyoon Lyoo, Sujung Yoon, Tae-Suk Kim, Jaeuk Hwang, Jieun E Kim, Wangyoun Won, Sujin Bae, Perry F Renshaw

Mentions

121
Peak: 16 in Mar 2022
across 7 sources since Jun 2021

Extended reach

1,188,731
potential audience

Total likes

11,503

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Mentions per month

Jun 2021 – Oct 2025

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AI synopsis

What people are saying

The analysis reflects a generally positive and curious attitude toward the research, with examples like mentions of 'creatine improving antidepressant response' and references to previous promising studies. The tone and context indicate that many see this as an accessible, safe potential enhancement to depression treatment, though some voices are cautious about the overall impact. This combination demonstrates moderate agreement, high interest, and collaborative engagement within the discussion community.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some expressing support or optimism about creatine's potential benefits for depression treatment.

InterestHigh interest

The discussions show high curiosity, especially around the promising results and practical implications of adding creatine to existing therapies.

EngagementModerate engagement

Participants reference specific studies and share insights, indicating moderate engagement with the research details.

ImpactModerate impact

The social discussions suggest moderate impact, with some considering the findings as potentially transformative, but overall consensus on immediate change is limited.

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RT @jerryteixeira: Creatine is cheap, safe, and may have a synergistic effect improving the efficacy of SSRI's in those with major depressi…

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RT @jerryteixeira: Creatine is cheap, safe, and may have a synergistic effect improving the efficacy of SSRI's in those with major depressi…

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RT @jerryteixeira: Creatine is cheap, safe, and may have a synergistic effect improving the efficacy of SSRI's in those with major depressi…

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RT @jerryteixeira: Creatine is cheap, safe, and may have a synergistic effect improving the efficacy of SSRI's in those with major depressi…

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Creatine is cheap, safe, and may have a synergistic effect improving the efficacy of SSRI's in those with major depressive disorder https://t.co/2fyzpplSHS

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RT @michaelmantzmd: RCT Study showing improvements in depression when Creatine (5gms/day) was added to SSRI therapy. A randomized, double…

Feb 28, 2022 · 1 share · 1,261 followers View post →
Mantz M.D. Bettermind Consulting
@michaelmantzmd · X

RCT Study showing improvements in depression when Creatine (5gms/day) was added to SSRI therapy. A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response… https://t.co/G2tUgHtGBJ

Feb 23, 2022 · 6 likes · 1 share · 10,678 followers View post →
Kenar Jhaveri, MD
@kdjhaveri.bsky.social · Bluesky

Nobility Trial Rich Furie et al @HofNorthwellDOM B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomized, double-blind, placebo-controlled trial https://ard.bmj.com/content/81/1/100.long

Jan 11, 2022 View post →
Mantz M.D. Bettermind Consulting
@michaelmantzmd · X

Boosting your Antidepressant (SSRI) with Creatine??? 2012 RCT study on depressed women: 5 grams of creatine/day showed promising results with significantly reduced depression ratings (HAM-D) which started after only 2 weeks of supplementation.

Jun 8, 2021 · 2 likes · 10,678 followers View post →