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Sci Transl Med August 2012 PMID 22896675

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Jeffrey J Iliff, Minghuan Wang, Yonghong Liao, Benjamin A Plogg, Weiguo Peng, Georg A Gundersen, Helene Benveniste, G Edward Vates, Rashid Deane, Steven A Goldman, Erlend A Nagelhus, Maiken Nedergaard

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Mentions

191
Peak: 3 in May 2022
across 6 sources since Jan 2020

Extended reach

77,270
potential audience

Total likes

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Jan 2020 – Sep 2025

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AI synopsis

What people are saying

The discussions reflect a high level of enthusiasm and support for the article, with example phrases like 'great scientific advance' and references to it as a 'game-changing discovery,' highlighting how words conveying novelty and importance foster excitement. Comments also connect the research to broader concerns such as Alzheimer’s, emphasizing its significance for brain health.

AgreementStrong agreement

Most discussions highlight strong support and excitement about the significance of the research, emphasizing its revolutionary impact on understanding brain waste clearance, which indicates agreement with the findings.

InterestHigh interest

Participants exhibit high curiosity and engagement, referencing the article, historical perspectives, and potential implications for diseases like Alzheimer’s, demonstrating strong interest.

EngagementModerate engagement

Posts include references to related studies, historical context, and calls to action like reading the full article, showing active participation and deep engagement with the material.

ImpactHigh impact

Several discussions underscore the paradigm-shifting nature of this research, noting how it overturns previous beliefs about the brain's waste systems and emphasizing its implications for neurodegenerative disease research, indicating high impact.

Abstract in brief

  • The brain clears extracellular proteins like amyloid not through lymphatic vessels, but via a paravascular pathway where CSF flows through brain tissues along spaces surrounding arteries, assisted by astrocyte water channels such as AQP4.
  • In vivo imaging shows that CSF enters the brain along paravascular routes, and this flow is crucial for clearing waste like amyloid; loss of AQP4 slows down this process significantly, indicating astrocytes play a key role.
  • Impairment of this paravascular clearance pathway may lead to the accumulation of harmful proteins, potentially contributing to neurodegenerative diseases like Alzheimer’s, highlighting its importance in maintaining brain health.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Dr. Fernando Gomes
@drfernandoneuro · X

Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

May 27, 2022 · 36 likes · 7 shares · 8,903 followers View post →
Yulia Mit
@MitYulia · X

1. Iliff, J. J., et al. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science Translational Medicine, 4(147), 147ra111. 2. Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis

May 26, 2025 · 20 likes · 1,362 followers View post →
christian graves
@0xbrekolazh · X

@analog_ashley @patrickmineault iliff et al 2012 https://t.co/ywH1HsV0nA

Aug 14, 2023 · 7 likes · 584 followers View post →
Sammy
@NeuroSGS · X

https://t.co/1ACICMoKng

Aug 14, 2023 · 4 likes · 12,136 followers View post →
Lauren Hablitz
@LaurenHablitz · X

Here's the original paper: https://t.co/EaJZ40UY9w

Aug 15, 2022 · 4 likes · 470 followers View post →
Federico Castillo Álvarez
@fedefedeson · X

Clásicamente se consideró que el sistema nervioso central era la única estructura humana sin sistema linfático (sistema implicado en la limpieza e inmunidad). En 2012 la ciencia una vez más demostró que estábamos equivocados, con un gran avance https://t.co/JQhIS7wuW8

Nov 6, 2023 · 3 likes · 1 share · 6,676 followers View post →

All mentions

Daniel Montero
@ndanmontero · X

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β Sci Transl Med. https://t.co/kBybiEurbb

Sep 5, 2025 · 4,679 followers View post →
Farina M. Yusoff
@DrMYFarina · X

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β | Science Translational Medicine https://t.co/0PYCYhEhn0

Aug 26, 2025 · 197 followers View post →
Yulia Mit
@MitYulia · X

1. Iliff, J. J., et al. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science Translational Medicine, 4(147), 147ra111. 2. Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis

May 26, 2025 · 20 likes · 1,362 followers View post →
Y.h.Calvin Chan
@calviology · X

The glymphatic system clears away metabolic waste products, including amyloid-beta (Aβ), which is associated with Alzheimer's disease. Efficient clearance is crucial for brain health. https://t.co/FncsapyC93

Dec 27, 2024 · 17 followers View post →
AliciaGM
@Aliciaglautwips · X

RT @fedefedeson: Clásicamente se consideró que el sistema nervioso central era la única estructura humana sin sistema linfático (sistema im…

Nov 7, 2023 · 1 share · 540 followers View post →
Morgana
@Morgana38535623 · X

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β | Science Translational Medicine https://t.co/fthk5GqESu

Nov 7, 2023 · 211 followers View post →
Federico Castillo Álvarez
@fedefedeson · X

Clásicamente se consideró que el sistema nervioso central era la única estructura humana sin sistema linfático (sistema implicado en la limpieza e inmunidad). En 2012 la ciencia una vez más demostró que estábamos equivocados, con un gran avance https://t.co/JQhIS7wuW8

Nov 6, 2023 · 3 likes · 1 share · 6,676 followers View post →
Mirka Knappová
@Mi81039Mirka · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

Sep 11, 2023 · 7 shares · 16 followers View post →
christian graves
@0xbrekolazh · X

@analog_ashley @patrickmineault iliff et al 2012 https://t.co/ywH1HsV0nA

Aug 14, 2023 · 7 likes · 584 followers View post →
Sammy
@NeuroSGS · X

https://t.co/1ACICMoKng

Aug 14, 2023 · 4 likes · 12,136 followers View post →
Dr David Bruce
@DrBru53086 · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

May 25, 2023 · 7 shares · 71 followers View post →
Pirkko-Liisa Lehtinen
@PirkkoLiisaLeh2 · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

Apr 2, 2023 · 7 shares · 257 followers View post →
Dr. Fernando Gomes
@drfernadoneuros · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

Nov 21, 2022 · 7 shares · 19 followers View post →
多情仏心
@jiangminjp · X

"（A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β. Sci Transl Med. 2012 Aug 15; 4(147): 147ra111）（Garbage Truck of the Brain. Science. 2013 Jun 28; 340(6140): 1529–1530）"

Nov 12, 2022 · 1,757 followers View post →
Lauren Hablitz
@LaurenHablitz · X

Here's the original paper: https://t.co/EaJZ40UY9w

Aug 15, 2022 · 4 likes · 470 followers View post →
Academia Brasileira do Sono (ABS)
@absono_ · X

Saiba mais no estudo: https://t.co/ku1irUmP7k #sono #abs #absono #sistemaglinfatico #medicinadosono #sonodequalidade https://t.co/FbQT76kWbK

Jul 13, 2022 · 292 followers View post →
Dr. Fernando Gomes
@Drfernandoneurr · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

May 27, 2022 · 7 shares · 1,223 followers View post →
Yolanda Marin Diaz
@YolandaMarinDi1 · X

RT @drfernandoneuro: Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

May 27, 2022 · 7 shares · 137 followers View post →
Dr. Fernando Gomes
@drfernandoneuro · X

Ficou curioso para saber mais? Leia o artigo completo em: https://t.co/wsVM39J93l https://t.co/bIScmdlLET

May 27, 2022 · 36 likes · 7 shares · 8,903 followers View post →
Harold Wu
@yfw3u · X

今天午會討論 glymphantic system，應該是 2012 年最重要的神經學突破吧 https://t.co/Bi8Qdn6HnZ

Mar 30, 2022 · 3 likes · 581 followers View post →
christian graves
@0xbrekolazh · X

just hiding in plain site https://t.co/ywH1HsV0nA

Nov 20, 2021 · 584 followers View post →
Julien Hernandez
@Barbusceptique · X

@alexandra_gros @Animula_tenera @MHainselin En faisant mes recherches, j'ai retrouvé l'article qui propose ce concept pour la première fois en 2012 : https://t.co/ihdGtqroBc

Dec 14, 2020 · 1 like · 5,987 followers View post →
epiMedTech Global
@epimedtech · X

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β https://t.co/aMDLM3Qpr5

Jan 2, 2020 · 2 likes · 39 followers View post →