Obes Rev November 2012 PMID 22905670

Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors.

F L Santos, S S Esteves, A da Costa Pereira, W S Yancy, J P L Nunes

Mentions

152
Peak: 4 in Feb 2023
across 6 sources since Apr 2019

Extended reach

1,923,367
potential audience

Total likes

30,718

Video views

1,515,779

Mentions per month

Apr 2019 – Oct 2025

Where it's discussed

  • Facebook57 posts
  • News39 articles
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  • Blogs14 articles
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AI synopsis

What people are saying

The discussions demonstrate strong interest and engagement by highlighting specific health benefits of low carb diets, such as lowering blood pressure and triglycerides, and referencing detailed results, but many also acknowledge ongoing debates about long-term impacts, which tempers the perceived overall influence of the publication.

AgreementModerate agreement

Most discussions recognize the findings of the review, with some emphasizing benefits like reduced blood pressure and cardiovascular risk factors.

InterestHigh interest

The discussions express high interest by focusing on specific health markers, diet types, and implications, showing participants find the topic relevant.

EngagementHigh engagement

People reference detailed outcomes, such as reductions in triglycerides and blood pressure, and debate methodological issues, indicating deep engagement.

ImpactModerate impact

While some posts highlight potential health improvements, the overall impact seems moderate, as debates include uncertainties about long-term effects and conflicting evidence.

Abstract in brief

  • This systematic review and meta-analysis examined 17 clinical trials involving 1,141 obese patients to evaluate how low-carbohydrate diets (LCD) affect weight and cardiovascular risk factors.
  • The results indicated that LCDs significantly improved various health markers, including reductions in body weight, BMI, abdominal circumference, blood pressure, triglycerides, fasting glucose, glycated hemoglobin, plasma insulin, and C-reactive protein, while increasing HDL cholesterol; LDL cholesterol and creatinine levels remained unchanged.
  • Although LCDs showed promising short-term benefits for weight loss and cardiovascular health, the long-term effects on overall health are still uncertain due to limited data.]

Top posts

Most liked on X and Bluesky
Nature Portfolio
@natureportfolio.nature.com · Bluesky

A systematic review and meta-analysis of clinical trials investigating obesity management medications reports that tirzepatide and semaglutide are the most effective in reducing body weight and obesity-related complications, according to a paper in Nature Medicine. #medsky

Oct 9, 2025 · 13 likes · 5 shares View post →
DiscoStew
@DiscoStew66 · X

Low carb diets reduce body weight, body mass index, abdominal circumference, blood pressure, triglycerides, fasting plasma glucose, glycated haemoglobin, plasma insulin, plasma C-reactive protein, and increase HDL

Mar 23, 2021 · 9 likes · 1 share · 10,804 followers View post →
Bradley Chillerman, PhD
@BroChillerman · X

@EricTopol @CellCellPress @PTurnbaugh @DrKristaVarady It's premature to claim keto increases CVD. There's simply no long term quality evidence to evaluate https://t.co/OQUAoKGvrA https://t.co/K3WcQq4HuW https://t.co/zwv4VireUg https://t.co/02koCqbgpd But short term trial evidence is clear: keto improves health and decreases CVD risk

Jul 25, 2024 · 5 likes · 352 followers View post →
Jose C Souto, MD
@jcsouto · X

@Malelo2711 @mauriciomezomo @lsdefraga @TaschnerNatalia @hungryeyebrows @AJKowaltowski Sim, o texto (não é dela) está factualmente errado: https://t.co/1czVqKLFh0 Mas veja, ñ era esse o ponto do tweet. O ponto dela eram os graves efeitos deletérios sobre autoestima dos adolescentes causados p/ esses influenciadores digitais - o Instagram, de fato, faz mal à saúde

Mar 20, 2022 · 4 likes · 14,575 followers View post →
Alan Watson
@DietHeartNews · X

@moreyraortho https://t.co/o9QCgGXeMp

Jul 7, 2020 · 3 likes · 1 share · 70,468 followers View post →
Doutor Doc MD.
@Doutor_Doc · X

Referencias: https://t.co/VAuzW6MQQg https://t.co/VJLl0UF9tu https://t.co/fU5AJqOOJO https://t.co/mGF7SdiMdV https://t.co/xNqtpQnirj https://t.co/oZHp1EKU1C https://t.co/lAMDr4vjxb https://t.co/DQeMsjP0oH https://t.co/pdw0C4m9mL

Feb 3, 2023 · 3 likes · 65,610 followers View post →

All mentions

Nature Portfolio
@natureportfolio.nature.com · Bluesky

A systematic review and meta-analysis of clinical trials investigating obesity management medications reports that tirzepatide and semaglutide are the most effective in reducing body weight and obesity-related complications, according to a paper in Nature Medicine. #medsky

Oct 9, 2025 · 13 likes · 5 shares View post →
NF Bot
@nfbot.bsky.social · Bluesky

Predicting epilepsy in patients diagnosed with intracranial meningiomas: A systematic review and meta-analysis of clinical and anatomical risk factors

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@kristogabriel.bsky.social · Bluesky

The effects of silymarin supplementation on metabolic status and oxidative stress in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials.

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ES/IODE
@esiode.bsky.social · Bluesky

May 8, 2025 View post →
Eric Morris
@contextpsych.bsky.social · Bluesky

Cognitive-behavioural therapy (CBT) for outpatients with anorexia nervosa: a systematic review and meta-analysis of clinical effectiveness

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medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

Placebo and Nocebo Responses in Multiple System Atrophy - a systematic review and meta-analysis of clinical trials https://www.medrxiv.org/content/10.1101/2024.11.05.24316747v1

Nov 5, 2024 View post →
Bradley Chillerman, PhD
@BroChillerman · X

@ElaineVigneault https://t.co/XNx9l2OtAV Low carb lowered CVD risk independent of weight loss https://t.co/zwv4ViqH4I Low carb improves blood pressure, trigs, glucose, a1c, insulin, CRP, & HDL https://t.co/OQUAoKFXC2 Keto resulted in 11.9% reduction in ASCVD risk score

Oct 22, 2024 · 352 followers View post →
Bradley Chillerman, PhD
@BroChillerman · X

@RogerSeheult https://t.co/mNl98pflJL No RCT evidence that changes in LDLc via diet affect CVD or mortality https://t.co/rDol9781Sr https://t.co/vReWVdvjLr https://t.co/KlkVCONLLL MA of RCTs show no effects from meat https://t.co/zwv4VireUg High meat low carb diets improve metabolic health

Sep 17, 2024 · 352 followers View post →
Bradley Chillerman, PhD
@BroChillerman · X

@NutritionMadeS3 Short term RCTs: carb restriction lowers systolic bp by 4.81 mmHg & diastolic bp by 3.10 mmHg. https://t.co/zwv4VireUg High insulin -> high sodium retention, regardless of sodium intake. https://t.co/fiU6p0DERK Keto reduced systolic bp more than DASH after 4 months

Aug 5, 2024 · 3 likes · 352 followers View post →
medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

Mitigating the Opioid Epidemic: The Role of Cannabinoids in Chronic Pain Management - A Systematic Review and Meta-Analysis of Clinical Evidence and Mechanisms https://www.medrxiv.org/content/10.1101/2024.07.14.24310378v1

Aug 1, 2024 View post →
Bradley Chillerman, PhD
@BroChillerman · X

@EricTopol @CellCellPress @PTurnbaugh @DrKristaVarady It's premature to claim keto increases CVD. There's simply no long term quality evidence to evaluate https://t.co/OQUAoKGvrA https://t.co/K3WcQq4HuW https://t.co/zwv4VireUg https://t.co/02koCqbgpd But short term trial evidence is clear: keto improves health and decreases CVD risk

Jul 25, 2024 · 5 likes · 352 followers View post →
Bradley Chillerman, PhD
@BroChillerman · X

@triagemethod @stathi_ Even low carb (not strictly keto) reduces blood pressure. SR of clinical trials: low carb reduced systolic blood pressure by 4.81 mm Hg and diastolic blood pressure by 3.10 mm Hg https://t.co/zwv4ViqH4I

Jun 24, 2024 · 1 like · 352 followers View post →
Éric Maeker
@dr.maeker.fr · Bluesky

Multidisciplinary inpatient rehabilitation for older adults with COVID-19: a systematic review and meta-analysis of clinical and process outcomes. BMC Geriatr 2023 2/5

Apr 22, 2024 · 1 share View post →
POPLINE
@POPLINE_org · X

Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors https://t.co/piFqMvnzMj https://t.co/SKEwI3VflW

Feb 17, 2024 · 5,269 followers View post →
kenia91
@kenia913 · X

@LMiliu @Yo_soy_JulyR Por ejemplo? https://t.co/911rp3uxIi

Aug 1, 2023 · 1 like · 284 followers View post →
Piotr Leski
@LeskiPiotr · X

@TomaszLaszcz @Kamil_Paprotny @DrKermitHouse ale jakie to ma znaczenie, jaki bedzie LDL (choc są badania, ktore mowią, że nie podnosi), skoro z badan wynika, że diety niskoweglowodanowe nie zwiekszaja ryzyka chorbo sercowo-naczyniowych, a wręcz przeciwnie? https://t.co/xTlh2O8pmv

Jul 18, 2023 · 14,059 followers View post →
Perfect Keto
@perfectketones · X

May 15, 2023 · 5,242 followers View post →
Alvar Aaltopelti
@alvaraaltopelti · X

@JuhaniKnuuti Ja koska olet mahdollisesti niin boomer, ettet vain tajua, niin tässä vielä kerran. https://t.co/gv7SBig2rv

Apr 17, 2023 · 542 followers View post →
Alvar Aaltopelti
@alvaraaltopelti · X

@JuhaniKnuuti Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Katso tuo aiempi, vai etkö osaa käyttää edes twitteriä

Apr 17, 2023 · 542 followers View post →
Alvar Aaltopelti
@alvaraaltopelti · X

@JuhaniKnuuti Mikä siinä on niin vaikeaa? https://t.co/gv7SBig2rv

Apr 16, 2023 · 542 followers View post →
Doutor Doc MD.
@Doutor_Doc · X

@MnicaOl66576715 Referencias: https://t.co/AYO5ooILzZ https://t.co/Gnxw3a408S https://t.co/V0vrkEnsF6 https://t.co/Ungvpil14n https://t.co/v82ohQTq5S https://t.co/2LE1SKQTyt https://t.co/lAMDr4vjxb https://t.co/XIUDC3T8ed https://t.co/30WkXJVgLP

Feb 3, 2023 · 65,610 followers View post →
Doutor Doc MD.
@Doutor_Doc · X

@DenilsonFAraujo Referencias: https://t.co/AYO5ooILzZ https://t.co/Gnxw3a408S https://t.co/V0vrkEnsF6 https://t.co/Ungvpil14n https://t.co/v82ohQTq5S https://t.co/2LE1SKQTyt https://t.co/lAMDr4vjxb https://t.co/XIUDC3T8ed https://t.co/30WkXJVgLP

Feb 3, 2023 · 1 like · 65,610 followers View post →
Doutor Doc MD.
@Doutor_Doc · X

@MaxBearzi Referencias: https://t.co/AYO5ooILzZ https://t.co/Gnxw3a408S https://t.co/V0vrkEnsF6 https://t.co/Ungvpil14n https://t.co/v82ohQTq5S https://t.co/2LE1SKQTyt https://t.co/lAMDr4vjxb https://t.co/XIUDC3T8ed https://t.co/30WkXJVgLP

Feb 3, 2023 · 65,610 followers View post →
Doutor Doc MD.
@Doutor_Doc · X

Referencias: https://t.co/VAuzW6MQQg https://t.co/VJLl0UF9tu https://t.co/fU5AJqOOJO https://t.co/mGF7SdiMdV https://t.co/xNqtpQnirj https://t.co/oZHp1EKU1C https://t.co/lAMDr4vjxb https://t.co/DQeMsjP0oH https://t.co/pdw0C4m9mL

Feb 3, 2023 · 3 likes · 65,610 followers View post →
歌島大輔@日本一の整形外科医YouTube(22万人)
@pedro0507 · X

F L Santos et al. Obes Rev. 2012 Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors

Jan 24, 2023 · 2 likes · 10,013 followers View post →
GregG
@GregG17241340 · X

@engwaiong @ScepticalDoctor @dr_cois https://t.co/OeHWlhuVZa

Apr 9, 2022 · 605 followers View post →
Jose C Souto, MD
@jcsouto · X

@Malelo2711 @mauriciomezomo @lsdefraga @TaschnerNatalia @hungryeyebrows @AJKowaltowski Sim, o texto (não é dela) está factualmente errado: https://t.co/1czVqKLFh0 Mas veja, ñ era esse o ponto do tweet. O ponto dela eram os graves efeitos deletérios sobre autoestima dos adolescentes causados p/ esses influenciadores digitais - o Instagram, de fato, faz mal à saúde

Mar 20, 2022 · 4 likes · 14,575 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

@theproof @DominicDAgosti2 ▪️ though a number of RCTs do show increased LDL-c with LC, which may be due to #LMHR or it may indeed be ⬆️ risk for ASVD. We don't know. Also, here's a systematic review & meta-analysis of 17 RCTs - image below shows the benefits of LC compared to LF

Mar 6, 2022 · 1,287 followers View post →
Vinagre
@Vinagre40482408 · X

@Uri85_ @_Punhal_ Además mejoran el control de glucosa. https://t.co/iVP06yXqjJ El síndrome metabólico: https://t.co/YvraUkCIAd Los triglicéridos: https://t.co/XX4R3fnngQ Etc etc etc.

Oct 29, 2021 · 733 followers View post →
Neil Appleby
@appleshk · X

RT @DiscoStew66: Low carb diets reduce body weight, body mass index, abdominal circumference, blood pressure, triglycerides, fasting plasma…

Mar 23, 2021 · 1 share · 763 followers View post →
DiscoStew
@DiscoStew66 · X

Low carb diets reduce body weight, body mass index, abdominal circumference, blood pressure, triglycerides, fasting plasma glucose, glycated haemoglobin, plasma insulin, plasma C-reactive protein, and increase HDL

Mar 23, 2021 · 9 likes · 1 share · 10,804 followers View post →
Kenar Jhaveri, MD
@kdjhaveri.bsky.social · Bluesky

Effect of Coffee Consumption on Renal Outcome: A Systematic Review and Meta-Analysis of Clinical Studies https://www.jrnjournal.org/article/S1051-2276(20)30209-0/fulltext#.YDF1fzEb5lt.twitter

Feb 20, 2021 View post →
SystematicReviewBot
@EvidenceRobot · X

RT @phantaszjia: Systematic review and meta‐analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk fac…

Dec 23, 2020 · 1 share · 6,708 followers View post →
Philip J Smith
@phantaszjia · X

Systematic review and meta‐analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors https://t.co/IAhiQbxqbH

Dec 23, 2020 · 1 share · 95 followers View post →
AleksJames
@aleksprisms · X

@TheEsteemedFox @AndreaLynnLewis https://t.co/AL4n6ESNKC

Oct 5, 2020 · 316 followers View post →
Belinda Keller
@belindakeller1 · X

https://t.co/g0z2q33Ckd

Jul 13, 2020 · 143 followers View post →
Alan Watson
@DietHeartNews · X

@moreyraortho https://t.co/o9QCgGXeMp

Jul 7, 2020 · 3 likes · 1 share · 70,468 followers View post →
⚡️JuninhoSereno
@juninhosereno1 · X

@NutritionMadeS3 @EAllen0417 @smac121 This meta-analysis of LCHF appears to show reductions in cardiovascular risk factors https://t.co/25HeZEVLEF And here, as an effective treatment of diabetes https://t.co/Aih0WPnZPb What might be the criticisms of such points of evidence that would rule them out as advisable?

Aug 22, 2019 · 307 followers View post →
Cameron McBride
@ketoCamMD · X

Santos FL, et al. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors. Obes Rev. 2012;13(11):1048-66.

Apr 4, 2019 · 71 followers View post →