Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal control over the production and/or accumulation of OXLAMs in certain tissues" https://t.co/n5Vx6ER726
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans.
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Jan 2019 – May 2025Where it's discussed
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What people are saying
Discussions prominently feature phrases like 'reduces harmful metabolites' and 'dietary impact,' indicating agreement and high interest in the research, especially among those linking it to disease prevention. The tone reflects curiosity and analytical engagement, with some posts questioning the broader significance and others emphasizing the potential influence on health practices.
Most discussions affirm the study’s findings that lowering dietary linoleic acid reduces harmful metabolites, showing general support.
The posts demonstrate high curiosity about health implications and dietary changes, indicating strong interest.
Many users delve into mechanistic details and implications, reflecting deep analysis and active discussion.
While some see potential for influencing dietary recommendations, the overall sentiment suggests cautious optimism rather than definitive paradigm shifts.
Abstract in brief
- The study investigates how reducing dietary linoleic acid (LA), a common fatty acid in human diets, can lower levels of bioactive oxidized LA metabolites (OXLAMs), which are linked to conditions like heart disease, dementia, and chronic pain.
- After a 12-week dietary intervention, participants showed a significant decrease in plasma OXLAMs and LA content in circulating lipids, indicating that diet can influence the levels of these potentially harmful compounds.
- These findings suggest that lowering dietary LA may reduce the biological formation of OXLAMs, potentially impacting the development or progression of various diseases, and highlight the need for further research on the clinical benefits of such dietary changes.
Top posts
Most liked on X and BlueskyLowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can reduce the synthesis and/or accumulation of oxidized LA derivatives that have been implicated in a variety of pathological conditions." https://t.co/n5Vx6F9gge https://t.co/cnFqKG2QbV
5/ 4-HNE is of course ONLY produced from oxidation of linoleic acid, the primary source of which is seed oils, not Parma ham. Do the authors know this? Yes, reference 7 explicitly looks at that relationship. https://t.co/zCjcPEVmvS https://t.co/tixeFttZ7Q
@MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what you actually care about, and it adds urgency... "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/zCjcPEVUlq #lcl6
@MorganPfiffner @futu00 @kevinnbass Not much research in humans yet, only a handful of studies, and very recent. "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/02QSRDhxs8
@The9611 @Thrillbits At flerumettet fett oksiderer lettere: https://t.co/RKUhgBPyGw Hva man spiser har noe å si: https://t.co/38aFgPWOFo https://t.co/38aFgPWOFo Skadelig: https://t.co/XmxD5yieug Du kan også teste dette selv. Smør den ene armen med solsikkeolje/rapsolje og sol deg. Sammenlign
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Sources Cont: https://t.co/CH1hODabMe https://t.co/e1Z7I90kS7 https://t.co/sW4N1r85uR https://t.co/qGsAi0IOYN https://t.co/z9gG5hxrnq https://t.co/rPcxDsKccv https://t.co/2RJZkNVTEu
Sources: https://t.co/2RJZkNVTEu https://t.co/g4WZtuwyXw https://t.co/q1bGZqkXJY https://t.co/rPcxDsKccv https://t.co/eGLYYzkS2P https://t.co/JLIG2pBVQi
@Alex_HPL @hubermanlab Huh https://t.co/AIbNOFkzgr
@The9611 @Thrillbits At flerumettet fett oksiderer lettere: https://t.co/RKUhgBPyGw Hva man spiser har noe å si: https://t.co/38aFgPWOFo https://t.co/38aFgPWOFo Skadelig: https://t.co/XmxD5yieug Du kan også teste dette selv. Smør den ene armen med solsikkeolje/rapsolje og sol deg. Sammenlign
@MaromIsGod @GageGuriel87 @thatkidspence @Robintruths @MaceAhWindu And here's another study that lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. For health, we want to be reducing oxidization as much as possible. https://t.co/ounvAsREQc
5/ 4-HNE is of course ONLY produced from oxidation of linoleic acid, the primary source of which is seed oils, not Parma ham. Do the authors know this? Yes, reference 7 explicitly looks at that relationship. https://t.co/zCjcPEVmvS https://t.co/tixeFttZ7Q
RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can redu…
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can reduce the synthesis and/or accumulation of oxidized LA derivatives that have been implicated in a variety of pathological conditions." https://t.co/n5Vx6F9gge https://t.co/cnFqKG2QbV
RT @TuckerGoodrich: @MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what y…
@MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what you actually care about, and it adds urgency... "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/zCjcPEVUlq #lcl6
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/dp46CRprm8
@MyNutritionSci @BenBikmanPhD Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. https://t.co/O33u9t2uFp
https://t.co/N6pRXu3HlA
@MohammedAlo Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. https://t.co/f0GoAfTaol
@aIIegoricaI @ShayneBrescia See https://t.co/GT9xsk6ivo (OXLAMs may be link between fatty liver disorder and diabetes) and https://t.co/A6Y0mVc79I (OXLAMs decrease with decreased LA intake)
Surprised there's still MD's actively promoting #seedoils and #pufa saying there's no evidence w/ human studies of peroxidation or inflammation
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans- We have always been told by food companies that Linoleic acid is healthy. New research may proof the opposite!!!!!! #lovenutritionandphysiology https://t.co/lfGHZxNKuS
RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…
RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…
RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal control over the production and/or accumulation of OXLAMs in certain tissues" https://t.co/n5Vx6ER726
While elevated levels of tissue OXLAMs are associated with diseases like Alzheimer’s (https://t.co/Av9cVekvAQ), this relationship too may not be causal.
There is even less evidence for reducing OXLAMs (by reducing linoleic acid) to prevent disease. OXLAMs are caused by linoleic acid intake (https://t.co/Av9cVekvAQ), which are enriched in vegetable oils.
@_atanas_ Arachidonic acid from linoleic acid (LA) stabilizes RyR2 but OXLAMs from LA add problems. DHA metabolites also stabilize RyR2. https://t.co/dp46CRGuo8 https://t.co/Q6ySa9TUgw "docosahexaenoic acid (DHA), eicosapentaenoic (EPA), arachidonic acid (AA), ... inhibit SOICR"
Reducir el AL en la dieta reduce los metabolitos bioactivos del AL oxidado en humanos: https://t.co/52EgpOunCB
Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/xAIPNIPFcB "These four OXLAMs have been mechanistically linked to pathological conditions ranging from cardiovascular disease to chronic pain."
@LizaWhyatt @nutritionrvn I like the way you think. There is very little appreciation of OXLAMS (oxidized linoleic acid metabolites) in my field and how the might be associated with IBD, cystitis, pancreatitis etc... https://t.co/oSe9UYLkxF
@Drlipid Hello Prof. Dayspring, due to my limited knowledge, I wanted your thoughts on this study https://t.co/3hCW0GDQoR and whether it shows that increasing dietary LA is actually counterproductive to reducing CVD? Thank you!
I just posted "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans -2012" on Reddit https://t.co/o3QIT05VTW
@MorganPfiffner @futu00 @kevinnbass Not much research in humans yet, only a handful of studies, and very recent. "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/02QSRDhxs8
RT @whsource: "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" from Chris Ramsden http://t.…
RT @NutriScience: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/NSFo7K3bI6