Prostaglandins Leukot Essent Fatty Acids February 2013 PMID 22959954

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans.

Christopher E Ramsden, Amit Ringel, Ariel E Feldstein, Ameer Y Taha, Beth A MacIntosh, Joseph R Hibbeln, Sharon F Majchrzak-Hong, Keturah R Faurot, Stanley I Rapoport, Yewon Cheon, Yoon-Mi Chung, Michael Berk, J Douglas Mann

Mentions

48
Peak: 6 in Jul 2021
across 5 sources since Jan 2019

Extended reach

958,257
potential audience

Total likes

859

Video views

26,862

Mentions per month

Jan 2019 – May 2025

Where it's discussed

  • X / Twitter32 posts
  • YouTube5 videos
  • Facebook5 posts
  • News3 articles
  • Blogs3 articles

AI synopsis

What people are saying

Discussions prominently feature phrases like 'reduces harmful metabolites' and 'dietary impact,' indicating agreement and high interest in the research, especially among those linking it to disease prevention. The tone reflects curiosity and analytical engagement, with some posts questioning the broader significance and others emphasizing the potential influence on health practices.

AgreementModerate agreement

Most discussions affirm the study’s findings that lowering dietary linoleic acid reduces harmful metabolites, showing general support.

InterestHigh interest

The posts demonstrate high curiosity about health implications and dietary changes, indicating strong interest.

EngagementHigh engagement

Many users delve into mechanistic details and implications, reflecting deep analysis and active discussion.

ImpactModerate impact

While some see potential for influencing dietary recommendations, the overall sentiment suggests cautious optimism rather than definitive paradigm shifts.

Abstract in brief

  • The study investigates how reducing dietary linoleic acid (LA), a common fatty acid in human diets, can lower levels of bioactive oxidized LA metabolites (OXLAMs), which are linked to conditions like heart disease, dementia, and chronic pain.
  • After a 12-week dietary intervention, participants showed a significant decrease in plasma OXLAMs and LA content in circulating lipids, indicating that diet can influence the levels of these potentially harmful compounds.
  • These findings suggest that lowering dietary LA may reduce the biological formation of OXLAMs, potentially impacting the development or progression of various diseases, and highlight the need for further research on the clinical benefits of such dietary changes.

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal control over the production and/or accumulation of OXLAMs in certain tissues" https://t.co/n5Vx6ER726

Jul 28, 2021 · 30 likes · 3 shares · 291,083 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can reduce the synthesis and/or accumulation of oxidized LA derivatives that have been implicated in a variety of pathological conditions." https://t.co/n5Vx6F9gge https://t.co/cnFqKG2QbV

Aug 3, 2023 · 19 likes · 2 shares · 291,083 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

5/ 4-HNE is of course ONLY produced from oxidation of linoleic acid, the primary source of which is seed oils, not Parma ham. Do the authors know this? Yes, reference 7 explicitly looks at that relationship. https://t.co/zCjcPEVmvS https://t.co/tixeFttZ7Q

Oct 4, 2023 · 12 likes · 1 share · 28,257 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what you actually care about, and it adds urgency... "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/zCjcPEVUlq #lcl6

Jul 22, 2023 · 10 likes · 1 share · 28,257 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@MorganPfiffner @futu00 @kevinnbass Not much research in humans yet, only a handful of studies, and very recent. "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/02QSRDhxs8

Jan 25, 2019 · 3 likes · 28,257 followers View post →
Banky Boksy
@bankyboksy · X

@The9611 @Thrillbits At flerumettet fett oksiderer lettere: https://t.co/RKUhgBPyGw Hva man spiser har noe å si: https://t.co/38aFgPWOFo https://t.co/38aFgPWOFo Skadelig: https://t.co/XmxD5yieug Du kan også teste dette selv. Smør den ene armen med solsikkeolje/rapsolje og sol deg. Sammenlign

Sep 5, 2024 · 3 likes · 349 followers View post →

All mentions

Mike Fave
@MikeFaveScience · X

Sources Cont: https://t.co/CH1hODabMe https://t.co/e1Z7I90kS7 https://t.co/sW4N1r85uR https://t.co/qGsAi0IOYN https://t.co/z9gG5hxrnq https://t.co/rPcxDsKccv https://t.co/2RJZkNVTEu

Apr 18, 2025 · 1 like · 1,616 followers View post →
Mike Fave
@MikeFaveScience · X

Sources: https://t.co/2RJZkNVTEu https://t.co/g4WZtuwyXw https://t.co/q1bGZqkXJY https://t.co/rPcxDsKccv https://t.co/eGLYYzkS2P https://t.co/JLIG2pBVQi

Apr 4, 2025 · 1 like · 1,616 followers View post →
Adrian
@elixirpath · X

@Alex_HPL @hubermanlab Huh https://t.co/AIbNOFkzgr

Dec 10, 2024 · 1 like · 11 followers View post →
Banky Boksy
@bankyboksy · X

@The9611 @Thrillbits At flerumettet fett oksiderer lettere: https://t.co/RKUhgBPyGw Hva man spiser har noe å si: https://t.co/38aFgPWOFo https://t.co/38aFgPWOFo Skadelig: https://t.co/XmxD5yieug Du kan også teste dette selv. Smør den ene armen med solsikkeolje/rapsolje og sol deg. Sammenlign

Sep 5, 2024 · 3 likes · 349 followers View post →
High T Meta
@HighTestMeta · X

@MaromIsGod @GageGuriel87 @thatkidspence @Robintruths @MaceAhWindu And here's another study that lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. For health, we want to be reducing oxidization as much as possible. https://t.co/ounvAsREQc

Feb 1, 2024 · 134 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

5/ 4-HNE is of course ONLY produced from oxidation of linoleic acid, the primary source of which is seed oils, not Parma ham. Do the authors know this? Yes, reference 7 explicitly looks at that relationship. https://t.co/zCjcPEVmvS https://t.co/tixeFttZ7Q

Oct 4, 2023 · 12 likes · 1 share · 28,257 followers View post →
McGill
@TheeAndyMcGill · X

RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can redu…

Aug 3, 2023 · 2 shares · 322 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "lowering dietary LA can reduce the synthesis and/or accumulation of oxidized LA derivatives that have been implicated in a variety of pathological conditions." https://t.co/n5Vx6F9gge https://t.co/cnFqKG2QbV

Aug 3, 2023 · 19 likes · 2 shares · 291,083 followers View post →
Seed Oil Disrespecter™️
@SeedOilDsrspctr · X

RT @TuckerGoodrich: @MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what y…

Jul 22, 2023 · 1 share · 107,796 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@MEATritionCom No, I'd start with the oxidized LA metabolites that actually drive the disease processes. That's what you actually care about, and it adds urgency... "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/zCjcPEVUlq #lcl6

Jul 22, 2023 · 10 likes · 1 share · 28,257 followers View post →
Rene Sugar
@renesugar · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/dp46CRprm8

May 18, 2023 · 3,952 followers View post →
B
@Wickedlipid · X

@MyNutritionSci @BenBikmanPhD Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. https://t.co/O33u9t2uFp

Mar 28, 2023 · 129 followers View post →
fvrmix
@fvrmix · X

https://t.co/N6pRXu3HlA

Mar 15, 2023 · 47 followers View post →
B
@Wickedlipid · X

@MohammedAlo Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. https://t.co/f0GoAfTaol

Mar 11, 2023 · 129 followers View post →
Peter Van Valkenburgh
@valkenburgh · X

@aIIegoricaI @ShayneBrescia See https://t.co/GT9xsk6ivo (OXLAMs may be link between fatty liver disorder and diabetes) and https://t.co/A6Y0mVc79I (OXLAMs decrease with decreased LA intake)

Oct 6, 2022 · 2 likes · 58,545 followers View post →
Adrian
@elixirpath · X

Surprised there's still MD's actively promoting #seedoils and #pufa saying there's no evidence w/ human studies of peroxidation or inflammation

Sep 10, 2022 · 1 like · 11 followers View post →
Marc Kinjet
@MarcKinjet · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans- We have always been told by food companies that Linoleic acid is healthy. New research may proof the opposite!!!!!! #lovenutritionandphysiology https://t.co/lfGHZxNKuS

Feb 13, 2022 · 2 likes · 533 followers View post →
JRod Freedom
@JrodFreedom · X

RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…

Jul 28, 2021 · 3 shares · 608 followers View post →
kike
@FUENTESMANZULLI · X

RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…

Jul 28, 2021 · 3 shares · 248 followers View post →
Carl Thomas Ball
@carltball122219 · X

RT @Mangan150: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal…

Jul 28, 2021 · 3 shares · 170 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans "dietary LA may hold proximal control over the production and/or accumulation of OXLAMs in certain tissues" https://t.co/n5Vx6ER726

Jul 28, 2021 · 30 likes · 3 shares · 291,083 followers View post →
Public Health Initiative Against Misinformation
@healthmisinfo · X

While elevated levels of tissue OXLAMs are associated with diseases like Alzheimer’s (https://t.co/Av9cVekvAQ), this relationship too may not be causal.

Jul 23, 2021 · 1 like · 4,152 followers View post →
Public Health Initiative Against Misinformation
@healthmisinfo · X

There is even less evidence for reducing OXLAMs (by reducing linoleic acid) to prevent disease. OXLAMs are caused by linoleic acid intake (https://t.co/Av9cVekvAQ), which are enriched in vegetable oils.

Jul 23, 2021 · 2 likes · 4,152 followers View post →
Rene Sugar
@renesugar · X

@_atanas_ Arachidonic acid from linoleic acid (LA) stabilizes RyR2 but OXLAMs from LA add problems. DHA metabolites also stabilize RyR2. https://t.co/dp46CRGuo8 https://t.co/Q6ySa9TUgw "docosahexaenoic acid (DHA), eicosapentaenoic (EPA), arachidonic acid (AA), ... inhibit SOICR"

Mar 18, 2021 · 3,952 followers View post →
Leli
@LeslieVianett · X

Reducir el AL en la dieta reduce los metabolitos bioactivos del AL oxidado en humanos: https://t.co/52EgpOunCB

Mar 13, 2021 · 384 followers View post →
Rene Sugar
@renesugar · X

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/xAIPNIPFcB "These four OXLAMs have been mechanistically linked to pathological conditions ranging from cardiovascular disease to chronic pain."

Feb 24, 2021 · 1 like · 3,952 followers View post →
Travis Einertson
@LowCarbVet · X

@LizaWhyatt @nutritionrvn I like the way you think. There is very little appreciation of OXLAMS (oxidized linoleic acid metabolites) in my field and how the might be associated with IBD, cystitis, pancreatitis etc... https://t.co/oSe9UYLkxF

Dec 27, 2020 · 1 like · 2,266 followers View post →
Be Optimal
@beoptimal1 · X

@Drlipid Hello Prof. Dayspring, due to my limited knowledge, I wanted your thoughts on this study https://t.co/3hCW0GDQoR and whether it shows that increasing dietary LA is actually counterproductive to reducing CVD? Thank you!

Dec 1, 2020 · 83 followers View post →
Travis Statham
@Travis_Statham · X

I just posted "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans -2012" on Reddit https://t.co/o3QIT05VTW

Jul 20, 2020 · 2 likes · 12,726 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@MorganPfiffner @futu00 @kevinnbass Not much research in humans yet, only a handful of studies, and very recent. "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" https://t.co/02QSRDhxs8

Jan 25, 2019 · 3 likes · 28,257 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

RT @whsource: "Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans" from Chris Ramsden http://t.…

Jan 24, 2019 · 6 shares · 28,257 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

RT @NutriScience: Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://t.co/NSFo7K3bI6

Jan 24, 2019 · 6 shares · 28,257 followers View post →