N Engl J Med September 2012 PMID 22992073

Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.

Ralf Gold, Ludwig Kappos, Douglas L Arnold, Amit Bar-Or, Gavin Giovannoni, Krzysztof Selmaj, Carlo Tornatore, Marianne T Sweetser, Minhua Yang, Sarah I Sheikh, Katherine T Dawson

Mentions

43
Peak: 7 in Feb 2024
across 5 sources since Aug 2019

Extended reach

98,905
potential audience

Total likes

494

Video views

10,427

Mentions per month

Aug 2019 – Sep 2025

Where it's discussed

  • X / Twitter15 posts
  • News11 articles
  • Facebook9 posts
  • Blogs6 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions reflect high interest in the study's findings, with comments on Tecfidera's efficacy and MRI improvements, exemplified by phrases like '90% effective' and references to pivotal trials. The tone balances acknowledgment of positive results with caution about endpoints and real-world impact, indicating moderate engagement and perceived significance.

AgreementModerate agreement

Most posts acknowledge the positive results of the study, emphasizing Tecfidera's effectiveness and relevance.

InterestHigh interest

The discussion shows high interest, with references to specific trials, MRI results, and implications for treatment decisions.

EngagementModerate engagement

Posts actively engage with the data by comparing treatments, suggesting discussions with providers, and referencing related trials, indicating moderate depth.

ImpactModerate impact

While the posts highlight the potential significance of the findings for MS treatment, they also caution about endpoints and real-world applications, suggesting moderate impact.

Abstract in brief

  • The phase 3 study showed that oral BG12 (dimethyl fumarate) significantly reduced relapse rates and disability progression in patients with relapsing-remitting multiple sclerosis compared to a placebo.
  • Patients taking BG12 experienced fewer relapses (around 26-27%) versus 46% with placebo, and had lower annualized relapse rates, indicating better disease control.
  • The treatment also decreased the number of new brain lesions detectable by MRI, and adverse events were noted but not detailed in the summary.]

Top posts

Most liked on X and Bluesky
Dr. Brandon Beaber
@Brandon_Beaber · X

Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping gadolinium enhancing lesions compared to placebo (column 2). A reminder that MRI endpoints do not equal disability endpoints. https://t.co/0kFLxAqQy2 https://t.co/982bUmc2cy

Feb 24, 2024 · 75 likes · 10 shares · 18,440 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 9 likes · 4 shares · 18,307 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

@djcrva I would suggest you talk with your provider about this question. You can take a look at the DEFINE trial (one of the pivotal trials for tecfidera prior to FDA approval) to see some of the data: https://t.co/ZE9LMmUzYl https://t.co/KGHABR0l9Z

Aug 28, 2019 · 2 likes · 18,440 followers View post →
Must Stop MS!
@MustStopMS · X

RT @Brandon_Beaber: How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 4 shares · 10,870 followers View post →
Simphiwe
@DrMandlesilo · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 25, 2024 · 10 shares · 8,502 followers View post →
Celia Oreja-Guevara
@C_OrejaGuevara · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 27, 2024 · 10 shares · 4,431 followers View post →

All mentions

zipjet
@zipjet · X

RT @Brandon_Beaber: How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 13, 2025 · 4 shares · 2,865 followers View post →
Slash
@takikardi92 · X

RT @Brandon_Beaber: How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 4 shares · 26 followers View post →
Must Stop MS!
@MustStopMS · X

RT @Brandon_Beaber: How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 4 shares · 10,870 followers View post →
Jerod
@JerodEwert · X

RT @Brandon_Beaber: How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 4 shares · 2,292 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

How Good is Tecfidera Long-Term? https://t.co/io7bASi0ot

Feb 12, 2025 · 9 likes · 4 shares · 18,307 followers View post →
Valeria Pozzilli
@VPozzilli · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Mar 15, 2024 · 10 shares · 34 followers View post →
Celia Oreja-Guevara
@C_OrejaGuevara · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 27, 2024 · 10 shares · 4,431 followers View post →
Luise
@FlodderLuise · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 26, 2024 · 10 shares · 144 followers View post →
Debbie Walker
@DebbieWalker62 · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 25, 2024 · 10 shares · 84 followers View post →
A Poet
@PoetAndWriting · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 25, 2024 · 10 shares · 514 followers View post →
Simphiwe
@DrMandlesilo · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 25, 2024 · 10 shares · 8,502 followers View post →
Jerod
@blacksectional · X

RT @Brandon_Beaber: Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping…

Feb 25, 2024 · 10 shares · 2,331 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

Tecfidera, often considered to be a lower-efficacy disease modifying therapy for MS was still 90% effective at stopping gadolinium enhancing lesions compared to placebo (column 2). A reminder that MRI endpoints do not equal disability endpoints. https://t.co/0kFLxAqQy2 https://t.co/982bUmc2cy

Feb 24, 2024 · 75 likes · 10 shares · 18,440 followers View post →
Krishan Maggon
@kkmaggon · X

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis | NEJM https://t.co/Pw2RZYJbJr https://t.co/dwRxvpKAm2

Aug 29, 2019 · 999 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

@djcrva I would suggest you talk with your provider about this question. You can take a look at the DEFINE trial (one of the pivotal trials for tecfidera prior to FDA approval) to see some of the data: https://t.co/ZE9LMmUzYl https://t.co/KGHABR0l9Z

Aug 28, 2019 · 2 likes · 18,440 followers View post →