PubHawk
N Engl J Med December 2012 PMID 23121374

Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.

Full text PDF Download social card

Mentions

68
Peak: 13 in Oct 2025
across 5 sources since Apr 2017

Extended reach

85,641
potential audience

Total likes

16

Video views

0

Mentions per month

Apr 2017 – Jan 2026

Where it's discussed

  • LinkedIn50 posts
  • News8 articles
  • X / Twitter7 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The group shows high interest in the EVOLVE trial's results, with comments referencing the controversy over adjusted analyses and the significance of unadjusted results, such as

AgreementModerate agreement

Many discussions reflect skepticism or cautious support, especially regarding the interpretation of EVOLVE trial results and the controversy over adjusted versus unadjusted analyses.

InterestHigh interest

Posts demonstrate high engagement with the implications of the trial and the controversy, indicating strong interest in the findings and methodological debates.

EngagementModerate engagement

Participants reference specific aspects like statistical adjustments, past studies, and clinical management, showing thoughtful engagement rather than dismissiveness.

ImpactNeutral impact

While the discussion is active, it mainly revolves around methodological and interpretative concerns; the posts suggest some influence but not definitive change in practice yet.

Abstract in brief

  • This clinical trial studied the effect of cinacalcet, a medication used to treat secondary hyperparathyroidism, on cardiovascular outcomes in dialysis patients and found that it did not significantly reduce the risk of death or major cardiovascular events despite some increased side effects.
  • Patients receiving cinacalcet experienced more cases of hypocalcemia and gastrointestinal issues compared to placebo, but the overall rate of primary adverse events was similar between the two groups.
  • The study suggests that, although cinacalcet is effective for managing mineral metabolism, its impact on reducing cardiovascular risk in dialysis patients remains uncertain based on the outcomes of this trial.
Read the full abstract

Top posts

Most liked on X and Bluesky
Graham Abra, MD
@GrahamAbra · X

@kidney_boy EVOLVE *ducks and runs away while argument ensues* https://t.co/1MKYrvkucD

Nov 30, 2025 · 6 likes · 2,676 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@ADAlthousePhD @statsepi @jd_wilko Yes (my opinion has changed on twitter thanks to you guys in the last few years) The feeling of cheating is strong Example from my field: https://t.co/1DyfvAEGQB Abstract specifically presents unadjusted results and that’s what all of us accepted https://t.co/AMeQ2ZwJaI

Aug 4, 2020 · 4 likes · 21,688 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@DominicMagirr @hvanspall @tmorris_mrc @load_dependent @ADAlthousePhD @joyfeed @statsepi Another older example 2012, EVOLVE The nephrology community did not accept the adjusted-for-baseline result and stuck to the unadjusted results here https://t.co/1DyfvAEGQB (Wrongly as we know now, though not prespecified) 1/2 https://t.co/uwnL6bD6od

Jul 24, 2021 · 2 likes · 21,688 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@ericau @boback @ADAlthousePhD @statsepi @jd_wilko see here https://t.co/EXgY5uZcPR I am not sure - in main paper they say this "We conducted prespecified multivariable analyses in which we adjusted for baseline characteristics." @eric_weinhandl might have more to add... https://t.co/5RfrBZKUt9

Aug 4, 2020 · 2 likes · 21,688 followers View post →
Tejas Desai, MD, MBA
@nephondemand · X

@GenNextMD EVOLVE https://t.co/C5pnJKnnSR Negative neph trial

Aug 22, 2019 · 1 like · 11,976 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

Mineral bone disease, phosphorus, and PTH are usually managed by protocol by the patient’s dialysis physician. There is no compelling evidence for calcium vs. non-calcium based phosphorus binders, & no clear clinical benefit for clinical lowering PTH. https://t.co/9J3co8HtHM

Feb 10, 2020 · 1 like · 5,082 followers View post →

All mentions

Graham Abra, MD
@GrahamAbra · X

@kidney_boy EVOLVE *ducks and runs away while argument ensues* https://t.co/1MKYrvkucD

Nov 30, 2025 · 6 likes · 2,676 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@DominicMagirr @hvanspall @tmorris_mrc @load_dependent @ADAlthousePhD @joyfeed @statsepi Another older example 2012, EVOLVE The nephrology community did not accept the adjusted-for-baseline result and stuck to the unadjusted results here https://t.co/1DyfvAEGQB (Wrongly as we know now, though not prespecified) 1/2 https://t.co/uwnL6bD6od

Jul 24, 2021 · 2 likes · 21,688 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@ericau @boback @ADAlthousePhD @statsepi @jd_wilko see here https://t.co/EXgY5uZcPR I am not sure - in main paper they say this "We conducted prespecified multivariable analyses in which we adjusted for baseline characteristics." @eric_weinhandl might have more to add... https://t.co/5RfrBZKUt9

Aug 4, 2020 · 2 likes · 21,688 followers View post →
Swapnil Hiremath @hswapnil.medsky.social
@hswapnil · X

@ADAlthousePhD @statsepi @jd_wilko Yes (my opinion has changed on twitter thanks to you guys in the last few years) The feeling of cheating is strong Example from my field: https://t.co/1DyfvAEGQB Abstract specifically presents unadjusted results and that’s what all of us accepted https://t.co/AMeQ2ZwJaI

Aug 4, 2020 · 4 likes · 21,688 followers View post →
Travis Smith, D.O. FAAEM
@RosenelliEM · X

Mineral bone disease, phosphorus, and PTH are usually managed by protocol by the patient’s dialysis physician. There is no compelling evidence for calcium vs. non-calcium based phosphorus binders, & no clear clinical benefit for clinical lowering PTH. https://t.co/9J3co8HtHM

Feb 10, 2020 · 1 like · 5,082 followers View post →
Tejas Desai, MD, MBA
@nephondemand · X

@GenNextMD EVOLVE https://t.co/C5pnJKnnSR Negative neph trial

Aug 22, 2019 · 1 like · 11,976 followers View post →
Hams
@Hams00na · X

RT @NEJM: Cinacalcet doesn’t lower death or major CV event risks in patients undergoing dialysis. http://t.co/ZOTX9OFY #kidneywk12

Jan 12, 2019 · 32 shares · 195 followers View post →
Joel Topf
@kidneyboy.bsky.social · Bluesky

Russian shenanigans in TOPCAT makes me wonder about near misses with Russian recruitment. EVOLVE? http://www.nejm.org/doi/full/10.1056/NEJMoa1205624#t=article

Apr 28, 2017 · 2 shares View post →
Novel Agents in CKD-MBD A Second Lease on Life or Flogging a ...
News

doi: 10.1056/NEJMoa1205624. PubMed. Chertow GM , Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis . N Engl J Med 2012 ; 367 ...

Jan 8, 2026 View →
Renal hyperparathyrodism | PPT
News

... 10.1056/NEJMoa1205624 Lai et al. Secondary and tertiary hyperparathyroidism: role of preoperative localization. ANZ J Surg. 2007 Oct;77(10):880-2 NICE ...

Jan 8, 2026 View →
ESKD | PDF | Chronic Kidney Disease | Nephrology
News

367: 2482–2494, 2012 10.1056/NEJMoa1205624 PubMed 07.024 PubMed 105. D€orr K, Kammer M, Reindl-Schwaighofer R, Lorenz M, Prikoszovich 90. Saravanan P ...

Jan 8, 2026 View →
s41598 025 29458 5 - Reference | PDF | Hemodialysis | Medical ...
News

2 https://doi.org/10.1056/NEJMoa1205624 (2012). 3 14. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD. 4 Update Work group. KDIGO 2017 clinical ...

Jan 8, 2026 View →
2023 ESC Guidelines For The Management of Cardiovascular ...
News

... 10.1056/NEJMoa2206038. Europe. Eur Heart J 2023 May 29:ehad260. https://doi ... NEJMoa1205624 1093/eurheartj/ehab777 742. Jamal SA, Vandermeer B, Raggi ...

Jan 8, 2026 View →
Articulo 8 | PDF | Dose (Biochemistry) | Chemistry
News

... 10.1056/NEJMoa1205624 PMID: 23121374. PLOS ONE | https://doi.org/10.1371/journal.pone.0235135 July 6, 2020 14 / 14. You might also like. Nutrients 05 01002 PDF.

Jan 8, 2026 View →
Understanding IgA Nephropathy: Insights from a Consultant ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Nov 12, 2025 View →
#aav #vasculitis #sharedcare #lumc #rheumatology #nephrology ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Nov 10, 2025 View →
BHV-1400: A novel TRAP degrader for IgA nephropathy treatment ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Nov 7, 2025 View →
Hyperlipidemia's role in Meibomian Gland Dysfunction: A review ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Nov 6, 2025 View →
EUS improves liver biopsy and portal pressure readings in clinical ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 31, 2025 View →
Noninvasive Liver Fibrosis Assessment: A Review | Emmanuel ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 29, 2025 View →
Acute brain injury | Quentin Monchicourt
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 29, 2025 View →
New dialysis filter shows promise for improving survival and health ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 27, 2025 View →
AI tool predicts CKD progression, improves resource allocation | Len ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 26, 2025 View →
Understanding Heart Failure: Pathophysiology and Management ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 24, 2025 View →
EVOLVE Trial: Cinacalcet and Cardiovascular Events in ...
LinkedIn

... Cardiovascular Disease in Patients Undergoing Dialysis. N Engl J Med. 2012;367(26):2482–2494. doi:10.1056/NEJMoa1205624.

Oct 23, 2025 View →
#pickedproject #ckd #msca #horizoneu #nephrology #erknet ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 20, 2025 View →
#edtnaerca #kidneytransplantation #chronickidneydisease ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 19, 2025 View →
ICD-10-CM 2026 Updates: Oncology, Endocrinology, Neurology ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 17, 2025 View →
New JACC article proposes Adipokine Hypothesis for HFpEF ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 14, 2025 View →
Dr Rasheeda Hall on Nephrology and Transplantation Studies ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 7, 2025 View →
AASD review on non-diabetic hypoglycemia: pitfalls, phenotypes ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 6, 2025 View →
Presentation on Anemia in CKD: Understanding and Innovations ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Sep 28, 2025 View →
New review compares SCIG and IVIG for CIDP and MMN | Hans ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Sep 28, 2025 View →
Hypertension-Related Heart Wall Thickening Patterns Found in ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Sep 2, 2025 View →
Understanding Sarcopenia: A Healthcare Challenge | Physiopedia ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Sep 1, 2025 View →
Sonographic findings of xanthogranulomatous pyelonephritis ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Aug 28, 2025 View →
Study reveals UDP-4-keto-6-deoxyglucose deficiency in Catel ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Aug 25, 2025 View →
Hyperkalemia: causes, symptoms, ECG changes, and emergency ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Aug 20, 2025 View →
"New study on PGE1 treatment for posterior segment ischemia ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Aug 14, 2025 View →
Shanghai Donglei Brain Hospital joins MedicaTour as new partner ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Aug 1, 2025 View →
Erythropoietin injections for CKD patients on dialysis: Why they ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jul 16, 2025 View →
FibroScan vs iLivTouch: Which Transient Elastography Device is ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jul 13, 2025 View →
New study on blood biomarkers for pediatric concussion diagnosis ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jul 1, 2025 View →
Steroids: Double-edged sword in stroke recovery | Faisal F. Alamri ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jun 19, 2025 View →
Lamotrigine safe for epilepsy patients with heart issues | Rutgers ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jun 12, 2025 View →
Nephritic and Nephrotic Syndromes: A Medical Comparison | Dr. Md ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jun 12, 2025 View →
UCLH and UCL led UK trial for Friedreich's ataxia treatment ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jun 5, 2025 View →
taVNS ineffective for chronic constipation: study | UEG Journal ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

May 23, 2025 View →
Association of MS lesions with migraine | Panos Gklinos | 13 ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Apr 23, 2025 View →
GLP-1RAs and SGLT2is lower Alzheimer risk in type 2 diabetes ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Apr 12, 2025 View →
AAN Meeting: Presenting 15 Abstracts on Autoimmune Disease ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Apr 8, 2025 View →
Semaglutide improves walking distance in PAD and T2D patients ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Mar 30, 2025 View →
Palmitoyl-carnitine and Cact: Key Regulators in Lung Development ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Mar 19, 2025 View →
#mirtarett #childrenfirst #paediatricresearch #rarediseases #rett ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Mar 3, 2025 View →
New YouTube Channel for ABIM Board Exam Prep | Ashkan Nasr ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Feb 27, 2025 View →
#dfg #uksh #obesity #inflammation #chronicdiseases ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Feb 26, 2025 View →
Xenotransplantation of a Porcine Kidney for End-Stage Kidney ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Feb 14, 2025 View →
2024 ESC Guidelines for the management of elevate blood pressure ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jan 22, 2025 View →
Longitudinal visual outcomes in idiopathic intracranial hypertension ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jan 16, 2025 View →
#wilbourn #split #fasciculation #reverse #hirayama | Dr Sandhya ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jan 12, 2025 View →
Is a mood change an early 'tell" in Creutzfeldt-Jakob disease (sCJD ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Jan 2, 2025 View →
Risk of Cardiovascular Diseases After Nonfocal Transient ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Dec 27, 2024 View →
Renal nerves in physiology, pathophysiology and interoception ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Dec 12, 2024 View →
Dapagliflozin Safe and Effective in CKD Stages 4 and 5 ...
LinkedIn

doi:10.1056/NEJMoa1205624 …more. Play Video. Video Player is loading. Loaded: 0%. Play Back to start. Stream Type LIVE. Current Time 0:00. /.

Oct 28, 2024 View →
Why the DASH and Mediterranean diets do not work for patients on ...
News

2012;doi:10.1056/NEJMoa1205624. Cooper BA, et al. N Engl J Med. 2010;doi:10.1056/NEJMoa1000552. Eknoyan G, et al. N Eng J Med. 2002;doi ...

Dec 3, 2018 View →
Kein klarer Vorteil für Cinacalcet | PZ – Pharmazeutische Zeitung
News

... 10.1056/NEJMoa1205624). /. Zur Übersicht Pharmazie... Außerdem in dieser Ausgabe... loading... TEILEN. Datenschutz bei der PZ. THEMEN. Kreislauf ...

Nov 19, 2012 View →