PubHawk
January 2013 PMID 23265337

The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.

Paul M Lavigne, Richard H Karas

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AI synopsis

What people are saying

The discussions frequently cite the clinical trials, emphasizing that niacin has been used for decades and is associated with reductions in cardiovascular events, as seen in phrases like 'niacin has been in clinical use for many decades.' The tone combines acknowledgment of historical usage with interpretations of recent trial data, reflecting moderate enthusiasm and recognition of its clinical significance.

AgreementModerate agreement

Most discussions support the idea that niacin has benefits for cardiovascular health based on the clinical data.

InterestModerate interest

Participants show moderate interest, focusing on the significance and history of niacin use in CVD prevention.

EngagementModerate engagement

Posts analyze the trials and mechanisms, indicating a basic but thoughtful engagement with the research details.

ImpactModerate impact

The discussions suggest that the publication influences perspectives on niacin’s role in preventing cardiovascular events, highlighting its historical and ongoing relevance.

Abstract in brief

  • The review analyzed data from 11 clinical trials with nearly 10,000 participants to evaluate if niacin helps prevent cardiovascular events, but results from the AIMHIGH trial challenged its overall effectiveness when added to statin therapy.
  • The meta-analysis found that niacin significantly reduces the risk of some cardiovascular events like coronary heart disease but did not show a significant effect on stroke incidence, and changes in HDL cholesterol levels caused by niacin were not directly linked to improved outcomes.
  • Overall, the evidence suggests that niacin may help reduce certain cardiovascular risks through mechanisms other than raising HDL cholesterol, but recent studies like AIMHIGH have raised questions about its benefit when used with other lipid-lowering treatments.]
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سعود الشهري
@saud_alshehry_ · X

للاستزادة

Jul 9, 2022 · 5 likes · 2 shares · 179,656 followers View post →
HOM3OSTASIS.com
@GPR109A · X

"Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" -- https://t.co/yo2NSrYi9Z https://t.co/AoeGEwadcU

Jun 22, 2023 · 5 likes · 1 share · 736 followers View post →
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@GPR109A · X

@skathire @VerveTx @EliLillyandCo Niacin tho: "Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" https://t.co/yo2NSrYi9Z

Jun 22, 2023 · 3 likes · 736 followers View post →
Dmitry Kats PhD, MPH
@InfinaLife · X

“The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State of Niacin in Cardiovascular Disease Prevention: A Systematic Review and Meta-Regression https://t.co/XcLN2T3xVm

Feb 27, 2024 · 2 likes · 3 shares · 1,160 followers View post →
HOM3OSTASIS.com
@GPR109A · X

@ifbacongrewont1 @NutritionMadeS3 @Drlipid @theproof "Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" -- https://t.co/yo2NSrYi9Z

Jun 22, 2023 · 2 likes · 1 share · 736 followers View post →
Andrey⚓️
@AndreyBur · X

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Andrey⚓️
@AndreyBur · X

https://t.co/0x9XS7YEXb

Sep 3, 2025 · 1 like · 2,726 followers View post →
Dmitry Kats PhD, MPH
@InfinaLife · X

RT @PureB3EF: “The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State o…

Jul 15, 2024 · 3 shares · 1,160 followers View post →
ХАРКІВ_РУЛІТ
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Jul 6, 2024 · 911 followers View post →
HOM3OSTASIS.com
@GPR109A · X

RT @GPR109A: “The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State of…

Mar 11, 2024 · 3 shares · 736 followers View post →
Dmitry Kats PhD, MPH
@InfinaLife · X

RT @GPR109A: “The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State of…

Mar 11, 2024 · 3 shares · 1,160 followers View post →
Dmitry Kats PhD, MPH
@InfinaLife · X

“The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State of Niacin in Cardiovascular Disease Prevention: A Systematic Review and Meta-Regression https://t.co/XcLN2T3xVm

Feb 27, 2024 · 2 likes · 3 shares · 1,160 followers View post →
Dmitry Kats PhD, MPH
@InfinaLife · X

“The consensus perspective derived from available clinical data supports that niacin reduces CVD events” The Current State of Niacin in Cardiovascular Disease Prevention: A Systematic Review and Meta-Regression - ScienceDirect https://t.co/XcLN2T3xVm

Feb 23, 2024 · 1 like · 1,160 followers View post →
HOM3OSTASIS.com
@GPR109A · X

RT @flushniacinNAG: "Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reductio…

Jul 3, 2023 · 1 share · 736 followers View post →
HOM3OSTASIS.com
@GPR109A · X

@skathire @VerveTx @EliLillyandCo Niacin tho: "Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" https://t.co/yo2NSrYi9Z

Jun 22, 2023 · 3 likes · 736 followers View post →
HOM3OSTASIS.com
@GPR109A · X

"Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" -- https://t.co/yo2NSrYi9Z https://t.co/AoeGEwadcU

Jun 22, 2023 · 5 likes · 1 share · 736 followers View post →
HOM3OSTASIS.com
@GPR109A · X

RT @flushniacinNAG: @ifbacongrewont1 @NutritionMadeS3 @Drlipid @theproof "Eleven eligible trials including 9,959 subjects were identified.…

Jun 22, 2023 · 1 share · 736 followers View post →
HOM3OSTASIS.com
@GPR109A · X

@ifbacongrewont1 @NutritionMadeS3 @Drlipid @theproof "Eleven eligible trials including 9,959 subjects were identified. Niacin use was associated with a significant reduction in the composite endpoints of any CVD event" "niacin has been in clinical use for many decades for the prevention of CVD" -- https://t.co/yo2NSrYi9Z

Jun 22, 2023 · 2 likes · 1 share · 736 followers View post →
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RT @saud_alshehry_: للاستزادة

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سعود الشهري
@saud_alshehry_ · X

للاستزادة

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