Neuron January 2013 PMID 23312516

Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.

Kunio Mizutari, Masato Fujioka, Makoto Hosoya, Naomi Bramhall, Hirotaka James Okano, Hideyuki Okano, Albert S B Edge

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Mentions

Peak: 1 in Feb 2013

across 5 sources since Feb 2013

Extended reach

15,916

potential audience

Total likes

132

Video views

15,674

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Feb 2013 – May 2025

Where it's discussed

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AI synopsis

What people are saying

Discussions highlight the promising results, with phrases like 'potential breakthrough' and 'must explore', reflecting excitement and recognition of the research's importance. The tone varies from enthusiastic to inquisitive, with some posts referencing the mechanisms involved, such as Notch signaling and hair cell regeneration, showing deeper engagement with the scientific content.

AgreementModerate agreement

Most discussions express support or excitement about the research, indicating general agreement on its significance.

InterestHigh interest

The posts show high interest, with many mentioning potential applications and implications for hearing restoration.

EngagementModerate engagement

The comments suggest moderate engagement, with some references to methodology and broader neurobiological impact.

ImpactHigh impact

The collective tone indicates that the community perceives this study as potentially transformative for treatments of deafness.

Abstract in brief

Notch inhibition can stimulate the regeneration of cochlear hair cells and partially restore hearing after noise-induced damage.
Using a secretase inhibitor to block Notch signaling increases Atoh1 levels, promoting hair cell differentiation from inner ear stem cells.
In vivo studies show supporting cells can convert into hair cells when Notch is inhibited, suggesting a potential treatment for deafness via pharmacological manipulation.]

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All mentions

Notch Inhibition Stimulates Cochlear Hair Cell Regeneration and Hearing Recovery

Notch inhibition can stimulate the regeneration of cochlear hair cells and partially restore hearing after noise-induced damage. Using a secretase inhibitor to block Notch signaling increases Atoh1 levels, promoting…

sixesfullofnines · Dec 14, 2013 13,379 views

Notch Inhibition Promotes Cochlear Hair Cell Regeneration and Hearing Recovery

Albert Edge PhD discusses how inhibiting Notch signaling stimulates cochlear hair cell regeneration and partially restores hearing in deaf mice, highlighting potential pharmacological treatments for deafness.

harvardstemcell · Feb 27, 2013 2,295 views

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