March 2013 PMID 23508038

The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions.

Ayumu Inutsuka, Akihiro Yamanaka

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Mentions

17
Peak: 2 in Jul 2024
across 4 sources since Oct 2021

Extended reach

429,941
potential audience

Total likes

5,614

Video views

426,456

Mentions per month

Oct 2021 – Sep 2025

Where it's discussed

  • Facebook6 posts
  • X / Twitter4 posts
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

Many discussions highlight the multifaceted roles of orexin, such as its connection to feeding, sleep, and reward, with some references to clinical conditions like narcolepsy, reflecting curiosity and recognition of research significance. The tone varies from informative to speculative, demonstrating curiosity-driven engagement and acknowledgment of the potential implications for neuroendocrine health and treatment.

AgreementModerate agreement

Most discussions acknowledge the significance of orexin in sleep regulation and related functions, especially in relation to narcolepsy.

InterestHigh interest

Posts reveal high curiosity about orexin's multiple roles, including feeding, sleep, and reward processing, indicating strong engagement with the topic.

EngagementModerate engagement

Participants reference specific mechanisms and potential implications, such as drug resistance in narcolepsy, showing moderate but thoughtful involvement.

ImpactModerate impact

The discussions underline the importance of orexin research in understanding sleep disorders and neuroendocrine functions, suggesting a meaningful scientific impact.

Abstract in brief

  • Orexins, also called hypocretins, are hormones in the hypothalamus that primarily help regulate sleep and wakefulness, but they also play roles in feeding, emotion, and energy balance.
  • These neurons respond to metabolic signals like ghrelin, leptin, and glucose, linking body's energy status to arousal and alertness, and they connect with systems involved in emotion, reward, and addiction.
  • The review explains how orexins maintain proper wakefulness and interact with other body systems to ensure survival by coordinating sleep, energy levels, emotional responses, and reward mechanisms.]

Top posts

Most liked on X and Bluesky
Simon L
@SnupSnus · X

@e_mc2_naruko @TakeshiSakurai There are some hint's (not proof-but tantalising hints) that narcoleptics seem resistant to drug addiction/stimulant seeking behavior: See: Inutsuka&Yamanaka, they report (1/3): https://t.co/RrnDNj18cu

Oct 16, 2021 · 1 like · 1,715 followers View post →
Love Your Lungs
@KingsResp · X

Narcolepsy with cataplexy (type 1) has been linked to low levels of the brain chemical hypocretin (AKA orexin). It is a neurotransmitter & plays a role in control of sleep-wake. Most hypocretin secreting cells are in the hypothalamus https://t.co/CdzWOfGZpl 5/n #RespEd #sleep https://t.co/waD2pLWk2W

May 21, 2023 · 1,622 followers View post →
All Files&News
@AllFilesNews1 · X

Frontiers | The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions | Endocrinology https://t.co/VueILzGZm8

Sep 7, 2022 · 117 followers View post →
Padma S
@sleepiatry · X

https://t.co/wVQLaXp3eL The various physiological roles for #orexin - feeding, maintenance of #sleep, autonomous regulation, and reward processing. https://t.co/OZUBzEvWTD

Dec 26, 2023 · 31 followers View post →

All mentions

Padma S
@sleepiatry · X

https://t.co/wVQLaXp3eL The various physiological roles for #orexin - feeding, maintenance of #sleep, autonomous regulation, and reward processing. https://t.co/OZUBzEvWTD

Dec 26, 2023 · 31 followers View post →
Love Your Lungs
@KingsResp · X

Narcolepsy with cataplexy (type 1) has been linked to low levels of the brain chemical hypocretin (AKA orexin). It is a neurotransmitter & plays a role in control of sleep-wake. Most hypocretin secreting cells are in the hypothalamus https://t.co/CdzWOfGZpl 5/n #RespEd #sleep https://t.co/waD2pLWk2W

May 21, 2023 · 1,622 followers View post →
All Files&News
@AllFilesNews1 · X

Frontiers | The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions | Endocrinology https://t.co/VueILzGZm8

Sep 7, 2022 · 117 followers View post →
Simon L
@SnupSnus · X

@e_mc2_naruko @TakeshiSakurai There are some hint's (not proof-but tantalising hints) that narcoleptics seem resistant to drug addiction/stimulant seeking behavior: See: Inutsuka&Yamanaka, they report (1/3): https://t.co/RrnDNj18cu

Oct 16, 2021 · 1 like · 1,715 followers View post →