Am J Physiol Endocrinol Metab May 2013 PMID 23512807

Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals.

Marjolein A Wijngaarden, Gerard C van der Zon, Ko Willems van Dijk, Hanno Pijl, Bruno Guigas

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Peak: 12 in Dec 2021

across 2 sources since Sep 2019

Extended reach

2,929,658

potential audience

Total likes

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Sep 2019 – Dec 2023

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AI synopsis

What people are saying

The discussions balance recognition of the study's potential, such as mentioning its focus on fasting's effects on metabolism, with skepticism about its conclusions, as seen in comments about its limited scope and transient effects. Words like 'interesting,' 'questionable,' and references to specific metabolic pathways contribute to an overall tone of cautious curiosity and moderate engagement.

AgreementModerate agreement

Most discussions acknowledge the relevance of the study, with some expressing curiosity about its findings, indicating moderate support and recognition of its importance.

InterestModerate interest

Participants show a moderate level of interest, referencing specific mechanisms like AMPK signaling and mitochondrial content, but also some dismissive comments about the study's limitations.

EngagementModerate engagement

Posts include technical references, such as activation of PPAR-alpha, and personal opinions, which demonstrate a reasonable level of engagement, though some dismiss ideas without deep analysis.

ImpactModerate impact

The overall tone suggests that the publication is seen as potentially impactful, but the discussions focus on its preliminary nature and limitations, reflecting moderate perceived significance.

Abstract in brief

The study found that prolonged fasting causes different metabolic responses in lean and obese individuals, including less body weight loss and a blunted shift from glucose to fat oxidation in obese subjects.
Obese individuals have lower baseline levels of insulin receptor expression and mitochondrial respiratory chain components in their skeletal muscle, and these differences are linked to their reduced metabolic flexibility during fasting.
Fasting decreased AMPK activity in lean individuals, but not in obese individuals, suggesting that altered energy-sensing pathways may contribute to the metabolic inflexibility seen in obesity.]

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All mentions

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Copy&Paste©️

@wdmorgan2 · X

How to Do Fat Fasting - What to Eat & How Often https://t.co/4XirszNSNE

Dec 19, 2023 · 2 likes · 3,257 followers View post →

Carnivore Augustus

@CarnivoreAugust · X

@gatordadsteve @DimitriRadoux @BHBEnjoyer @_shaunography_ @KetoCarnivore @anti_wokeist @exfatloss @markeatsmeat @BowTiedRunning Yes. https://t.co/6svAEJxRU8 https://t.co/GWYVTwA7tl

Aug 23, 2023 · 859 followers View post →

Carnivore Augustus

@CarnivoreAugust · X

@SamaHoole @bodyofwine PPAR-alpha gets activated when it senses lots of fat. https://t.co/7jFzSfgLDo

Jan 10, 2023 · 3 likes · 859 followers View post →

Patricia Alford

@plathelibrarian · X

@AlisaValdesRod1 "The protein expression of mitochondrial respiratory chain components, although not modified by fasting, was significantly reduced in obese subjects." This was limited study, & had they followed the subjects longer, thru more fasts, & diff measures, IDK? https://t.co/Xmvj7C3dTs

May 5, 2022 · 1,458 followers View post →

Kevin Davy

@davykevinp · X

Mar 23, 2022 · 3 likes · 1,309 followers View post →

Jan Vyjidak

@janvyjidak · X