Inhibition of pancreatic cancer and potentiation of gemcitabine effects by the extract of Pao Pereira.

Abstract in brief

• The extract of Pao Pereira (Pao) shows potential in fighting pancreatic cancer by inducing apoptosis in cancer cell lines and significantly reducing tumor growth and metastasis in mouse models.
• When used alone, Pao inhibits pancreatic tumor progression more effectively than gemcitabine (Gem), the standard chemotherapy drug; combining Pao with Gem enhances their overall anti-tumor effects, allowing lower doses of Gem.
• The study suggests that Pao Pereira extract could be a promising natural therapy to improve current pancreatic cancer treatments, potentially overcoming some limitations of existing therapies.]