@hubermanlab @NeuroCellPress Thanks for asking @hubermanlab. These claims started with this 2013 paper claiming psilocybin causes neurogenesis. I've never cited it because questionable methods. Kept blocking when colleagues tried to cite in our papers. Blind worship of neurogenesis. https://t.co/mVVowMQQEK
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning.
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Dec 2016 – Oct 2025Where it's discussed
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X / Twitter79 posts
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Facebook58 posts
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News17 articles
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Reddit9 posts
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YouTube3 videos
AI synopsis
What people are saying
The overall discussions reflect strong interest and active engagement, with participants referencing specific findings such as dose-dependent neurogenesis alterations and potential therapeutic applications for PTSD. Words like 'stimulated' and 'enhanced' convey a positive tone, while mentions of evolutionary benefits and neuroplasticity underscore the perceived significance of this research, though some skepticism about the mechanistic interpretations is also present.
Most discussions acknowledge the positive effects of psilocybin on neurogenesis and fear extinction, though some express caution or skepticism about overgeneralizing results.
Posts demonstrate high curiosity, referencing multiple studies and exploring potential applications, showing active engagement with the research.
Participants deep dive into details like dosage effects, evolutionary implications, and consequences for conditions like PTSD, indicating substantial involvement.
The conversations hint at the potential for this research to influence mental health treatments, but overall impact remains emerging, with some links to broader philosophical and evolutionary ideas.
Abstract in brief
- The study investigates how psilocybin (PSOP), a serotonin 5HT2A receptor agonist, affects the growth of new neurons in the hippocampus and the process of extinguishing fear memories in mice, with implications for treating conditions like PTSD.
- Mice given low doses of PSOP learned to forget fear responses more quickly, and these doses did not decrease neuron growth in the hippocampus, suggesting a potential link between neurogenesis and fear extinction.
- The research indicates that psilocybin and similar drugs may help with fear-related disorders by promoting neural plasticity and fear extinction, though their effects on different brain regions and receptor targets need further exploration.]
Top posts
Most liked on X and Bluesky"Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be explored as potential treatments for PTSD and related conditions.". Related conditions like mass formation psychosis too? https://t.co/ViLK26goGS
Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics https://t.co/6VKaJKKzKY
Sources: https://t.co/CFaOE7y1iQ https://t.co/wEsWgYknO9 https://t.co/aF8QDJIh4G https://t.co/GnAkomSeFe https://t.co/hMVIStmfya https://t.co/YWzsUGbZbo
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning https://t.co/tvSUH5Ip47 Full link to study: https://t.co/4Ym3Sl1d5k
#Psilocybin mushrooms prompt the brain to create new brain cells, a process known as #neurogenesis: https://t.co/rVVFQ0ZaDE 2. Psilocybin use results in personality changes, including increased openness: https://t.co/kdlQf5XYZr 3. https://t.co/HNPoevPKGj
All mentions
Impact of Recreational Drugs on Animals and Neural Mechanisms in Fear Extinction
Drugging animals may seem like a bad idea but youd be shocked to learn what it can teach scientists about disease biology animal behavior. The study explores how psilocybin affects hippocampal neurogenesis and fear…
Scientific Insights into Psilocybin Mushrooms and Their Effects
These are 5 scientific facts about psilocybin mushrooms that I personally find to be very interesting Explore how high doses induce mystical experiences with lasting personal and spiritual significance, and their…
Evaluating the Validity of the Stoned Ape Theory in Human Evolution
This video discusses the Stoned Ape Theory and its credibility, exploring how psychedelics may or may not have influenced human brain development, language, and culture. We also consider other scientific theories on…
RT @jhondoe2509: @BanounHelene @nytimes https://t.co/JRwxOUE57v https://t.co/9o4JEJseI5 https://t.co/PSB0DPthH0 https://t.co/fNMJys5bWB
@BanounHelene @nytimes https://t.co/JRwxOUE57v https://t.co/9o4JEJseI5 https://t.co/PSB0DPthH0 https://t.co/fNMJys5bWB
@Diinekis13 https://t.co/YGyF2PgFZO
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
@ErikaEcho23 @GroovyGreatness @LesleyMiss17638 @Lillysh55315152 https://t.co/fiGjxEEOBS
https://t.co/yzHHxlcpTh
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning - PubMed https://t.co/1cKtvNfdVE
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @ManojDoss: @zenbrainest What about this study that found evidence of a higher dose of psilocybin to decrease neurogenesis and a lower d…
@zenbrainest What about this study that found evidence of a higher dose of psilocybin to decrease neurogenesis and a lower dose to increase it? https://t.co/CMy6uVpcOm
RT @nectar_vector: @RDrachenstern @xBleaKx1 @dirkflei75 @BDK_Bund Wie der Affe seine #Wirbelsäule_streckte, damit seinen physischen, wie au…
@RDrachenstern @xBleaKx1 @dirkflei75 @BDK_Bund Wie der Affe seine #Wirbelsäule_streckte, damit seinen physischen, wie auch #virtuellen_Horizont_erweiterte, die #Angst_vor_Feuer_aufgab und es konservierte: "Effects of #psilocybin on #hippocampal_neurogenesis and #extinction of #trace_fear_conditioning" https://t.co/ksO6enP6HN
@newscientist Similar findings were suggested back in 2013 in the paper Effects of Psilocybin on Hippocampal Neurogenesis and Extinction of Trace Fear Conditioning https://t.co/TpFSkRIiPZ
@Njoerdrson @olliwaack Auch für #Angststörungen, #Depressionen, #Evolution etc.: https://t.co/ksO6enP6HN
@PeterGrahammer "Effects of #psilocybin on #hippocampal_neurogenesis and #extinction of #trace_fear_conditioning" https://t.co/ksO6enP6HN
@UsualRedAnt "Effects of #psilocybin on #hippocampal_neurogenesis and #extinction of #trace_fear_conditioning" https://t.co/ksO6eo69JN
@multitalentfrey @NDRinfo https://t.co/ksO6enOySf
@Volker_Pudt Wie der Affe seine #Wirbelsäule_streckte, damit seinen physischen, wie auch #virtuellen_Horizont_erweiterte, die #Angst_vor_Feuer_aufgab und es konservierte: "Effects of #psilocybin on #hippocampal_neurogenesis and #extinction of #trace_fear_conditioning" https://t.co/ksO6enOySf
@ufob0t @1933 #Increasing_neuroplasticity is #daily_conducted by our #pineal_gland's (N,N-)#DMT with #REM_dream. "#Fear_is_the_mind_killer" is a #scientific_fact, as you can't analyze of what you're too afraid to accurately observe. Psilocin reduced apes' #fear_of_fire: https://t.co/ksO6enOySf
@xtraa @olliwaack @stark_helmut @KarlHeinzHasliP #Psilocin (4-HO-N,N-DMT), das aktive Prinzip dahinter, ist ja auch wahrscheinlich nicht nur zufällig unserem #endogenen_Zirbeldrüsen-#DMT so ähnlich, da es auch zur #Streckung_der_Wirbelsäule anregt und den #Affen durch physische Horizonterweiterung half: https://t.co/ksO6enOySf
Sources: https://t.co/CFaOE7y1iQ https://t.co/wEsWgYknO9 https://t.co/aF8QDJIh4G https://t.co/GnAkomSeFe https://t.co/hMVIStmfya https://t.co/YWzsUGbZbo
@Josevahu Los papers: https://t.co/YLoMRGQgMR https://t.co/AjMHaujjHi https://t.co/xGMi8iZ0mk https://t.co/CIV174TC9J
@HKubin @_the_catfather @RoyceRoyal_DG @LauraCMKH21 Das hier von Jesus am Canterbury Plaster angepriesene #Psilocin (=4-HO-DMT; blauer Pilz-> oxidiertes Psilocin verfärbt sich blau) gleicht sehr unserem für Kreativität, im #REM-Traum und beim #Lethal_Upload (vulgo #Tod) ausgeschüttetem #DMT der Zirbeldrüse: https://t.co/ksO6enOySf https://t.co/s3GtcJdOLB
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
In fact, there is even evidence that psilocybin containing mushrooms may actually help to grow your brain (neurogenesis) https://t.co/R0w0rlWJxW
@EPolemicist @Graham__Hancock For the history of psychedelic use: David Lee Lewis reviewed publications, Graham's book Supernatural, Muraresku book The Immortality Key. Neurogenesis: https://t.co/22dZCCfSgd https://t.co/M10wxaHWVo https://t.co/3jY05q3raV Many others, yw!
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
Repeated administration of a psychedelic directly stimulated neurogenesis and increased BDNF mRNA levels up to a month after treatment. https://t.co/RTLosQ00qu
@davidwebbshow @group4 @MelBrooks To become human, #primates ate a very close chemical relative of N,N-DMT, 4-HO-N,N-DMT, #Psilocin. It stretched their spines, reduced fears and grew new ideas in their biological quantum computers' neuronal networks of how to conserve naturally occuring... https://t.co/ksO6enOySf
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning - PubMed https://t.co/P92XZYnbZx
I know some folks that can use help https://t.co/ZX0vvCtMpw
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
RT @drkohilathas: "Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be…
"Psilocybin facilitates extinction of the classically conditioned fear response, and this, and similar agents, should be explored as potential treatments for PTSD and related conditions.". Related conditions like mass formation psychosis too? https://t.co/ViLK26goGS
A psilocibina em doses baixas estava associada ao aumento no número de neurônios no hipocampo e extinção do comportamento de condicionamento ao medo https://t.co/IFfJ5A5hWC https://t.co/Odjy4mIJTK
@leoschilbach 4-HO-DMT (#Psilocin), die aktive Form des Psilocybin, erweitert nicht nur den virtuellen #Horizont, es regt auch zum Durchstrecken der Wirbelsäule an, was den physischen Horizont erweiterte und reduzierte Angst vor Neuem ermöglicht das zuvor "#Undenkbare". https://t.co/ksO6enOySf
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning - PubMed https://t.co/2c7Cc1RfB7
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning - PubMed https://t.co/gQmeLheW9a
@_Buddha_Quotes "Mother Mary"= Thyroxine "Holy Ghost" = DMT "Heaven", "Nirvana", "Quantum Information Potential", "God" etc. = Serotonin How apes became #human: #Psilocin, the active compound Psilocybin is split into, is 4-Hydroxy-N,N-dimethyltryptamin (4-HO-DMT): https://t.co/ksO6enOySf
RT @nectar_vector: @Vagab0nd8 @Darkfloppy1 #Neurogenese durch Psilocin + verstärktes Strecken der Wirbelsäule während der Wirkung könnten d…
@Vagab0nd8 @Darkfloppy1 #Neurogenese durch Psilocin + verstärktes Strecken der Wirbelsäule während der Wirkung könnten den Affen zum Menschen verholfen haben, da sich ja physischer + virtueller Horizont enorm erweitert hätte, zudem die reduzierte Angst vor so neuen #Erfahrungen! https://t.co/ksO6enOySf
@ch1llbaer @trolkragnpulova @Koelschejung26 @43ermilch @BodoMdB @faktastisch 4-HO-DMT (=Psilocin) verhalf unseren Vorfahren durch die dadurch verstärkte Neurogenese + dabei die adrenalin-induzierte Angst zu reduzieren, sich physisch zu strecken (NW bei Psilocin) + auch imaginär-#virtuelle #Horizonte zu erweitern für #Mentalmapping! https://t.co/ksO6enOySf https://t.co/IOSGWpcXrV
@ufob0t Would explain all the interdimensional beings as still ego-based, persona-focused perceptions of the quantum information potential's infinite permutations, as they've climbed our spine towards transcendence? https://t.co/ksO6enOySf https://t.co/T3342eEtXM https://t.co/SqpbKlhORd
@whosthatguurrrl Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning ~ https://t.co/l3dichl0G5 #Neuro
@Rainmaker1973 Obviously cosmology's physics are #mycophile, too, not only the apes/people who don't fear to think new things... https://t.co/ksO6enOySf
@springtime_eyre Es ermöglicht unseren REM-Traum ebenso, wie jegliche introspektive Reflexion und es ist inzwischen bewiesen, dass #Psilocin (4-HO-DMT) neurogenerative Effekte besitzt. Dabei streckt man sich und es erweitert somit den physischen und virtuellen Horizont... https://t.co/ksO6enOySf
@hubermanlab @NeuroCellPress @Drug_Researcher If we’re talking new neurons, then a look at hippocampus is best. Here u go. https://t.co/TT4ZZQKRkw
@ManojDoss @hubermanlab @NeuroCellPress @Drug_Researcher maybe https://t.co/apUel7XliP ?
RT @Drug_Researcher: @hubermanlab @NeuroCellPress Thanks for asking @hubermanlab. These claims started with this 2013 paper claiming psiloc…
@hubermanlab @NeuroCellPress Thanks for asking @hubermanlab. These claims started with this 2013 paper claiming psilocybin causes neurogenesis. I've never cited it because questionable methods. Kept blocking when colleagues tried to cite in our papers. Blind worship of neurogenesis. https://t.co/mVVowMQQEK
@hubermanlab @NeuroCellPress @Drug_Researcher https://t.co/StuDWxmP27 Have you seen this?
https://t.co/j00BCgNTto
@josegallucci https://t.co/sHvewl5AqU
@Harvard2H @OldCoinyBill @OddMan59903018 @daniel_bilar @pizzapicklespur @markorgan @LNeuroscientist @arkmedic @Parsifaler @LuigiWarren @helendale @jjcouey @daoyu @Daoyu15 @pathogenetics @WardBio 2 pings: 1. Lovelock argues that Gaia is the more complex “self-regulating organism.” 2. Didn’t fungus (shrooms) arrive before plant vegetation? @MAPS https://t.co/mJL0YAQUY0
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
RT @zenbrainest: Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics ht…
Interesting legacy paper on psilocybin--small doses enhance neurogenesis and larger doses diminish it. #psychedelics https://t.co/6VKaJKKzKY
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning [Briony J. Catlow, Shijie Song, Exp Brain Res 228, 481–491 (2013). https://t.co/nhRlRDqRB7] https://t.co/3W1YsxvcgO https://t.co/KreA9sjSYH
@drugb0t Psilocin is 4-HO-DMT + it probably stretched our spines during consumption by simians, thereby widening our physical & also mental horizons with a higher connectivity reached due to its' ingestion, which are both evolutionary gains: https://t.co/j332mB8gc0 https://t.co/QpLI2EQbBo
#Psilocybin mushrooms prompt the brain to create new brain cells, a process known as #neurogenesis: https://t.co/rVVFQ0ZaDE 2. Psilocybin use results in personality changes, including increased openness: https://t.co/kdlQf5XYZr 3. https://t.co/HNPoevPKGj
@tstopford @AndrewSoper13 @marydsoco @David_Cormack Endocannabinoid social signaling is essential for empathic behaviours enabling societies' existence over the egotistical Dopamine Ego-Dominance level of control freaks, OCD-victims and sadist(spiral victim)s: https://t.co/krEoMoB15t https://t.co/zqmO0rAL5e https://t.co/ElpjMw3Z6T https://t.co/6dZz5lpVSq
@RebeccaMadison_ 5/ which is easier generally to obtain in its "organic" form, dessicate, and measure dosage. Clinical trials on PTSD for psilocybin are still in phase 2 (https://t.co/YhReXuzy3u), but effective animal trials, similar neurogentic properties (https://t.co/DlPgzrCR0i),
RT @Grimhood: Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning https://t.co/tvSUH5Ip47 Full lin…
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning https://t.co/tvSUH5Ip47 Full link to study: https://t.co/4Ym3Sl1d5k
@dlx5dlx6 Gotta fix the brain rot. Repair the index. "Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning" https://t.co/CIZaqxbrjV https://t.co/z3gKvFWDjo
@thegoldenass1 @Drestradamus https://t.co/UsuOuSu4Jz
@seltbram Some resources for the curious: https://t.co/2BuBRV09IH https://t.co/V8jH5qswpB https://t.co/3AJ5ikdqEF https://t.co/dvfCtLjTyC https://t.co/csroEAa0kG https://t.co/kujxT0R0mh https://t.co/YSP0US8FkM https://t.co/wcvxXqMDMY https://t.co/wVBgz1j06k
Effects of #psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning https://t.co/5lSHSsN8Rx #psychedelics #neurology #benefits
RT @cannaworldsite: @Positivibes_420 yeah, just google it, there are multiple studies showing it https://t.co/pKrCM04Ob5 https://t.co/pS91…
@Positivibes_420 yeah, just google it, there are multiple studies showing it https://t.co/pKrCM04Ob5 https://t.co/pS916h7bH8 https://t.co/MFdv2LA8OE ...
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. - PubMed - NCBI https://t.co/kwyvkhjxFh
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