PubHawk
FASEB J September 2013 PMID 23739654

Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial.

Stefan M Pasiakos, Jay J Cao, Lee M Margolis, Edward R Sauter, Leah D Whigham, James P McClung, Jennifer C Rood, John W Carbone, Gerald F Combs, Andrew J Young

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Mentions

204
Peak: 7 in Apr 2023
across 6 sources since Jul 2018

Extended reach

282,825
potential audience

Total likes

1,511

Video views

46,122

Mentions per month

Jul 2018 – Jul 2025

Where it's discussed

  • Facebook108 posts
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  • Blogs5 articles
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  • Reddit2 posts

AI synopsis

What people are saying

Overall, the group actively engages with the research's implications, with examples like references to consuming 1.5 g/kg/day of protein to preserve lean mass, and questions about optimal protein intake, illustrating their interest and depth of discussion. The tone combines scientific curiosity with practical advice, supporting the higher agreement and engagement scores.

AgreementModerate agreement

Most discussions support the idea that consuming higher levels of protein helps preserve muscle during weight loss, reflecting moderate agreement with the study's findings.

InterestHigh interest

The discussions indicate a high level of interest, as many posts reference specific protein amounts, study implications, and practical applications.

EngagementHigh engagement

Posts often elaborate on methods, question RDA adequacy, and suggest training strategies, showing deep engagement with the research.

ImpactModerate impact

While the influence on personal fitness practices is noted, the broader impact remains moderate given the focus on individual and community insights rather than policy changes.

Abstract in brief

  • The study tested how different levels of dietary protein affect body composition and muscle protein synthesis during calorie restriction, with participants consuming 0.8 RDA, 1.6 RDA, and 2.4 RDA for 31 days.
  • Results showed that all participants lost weight, but those who ate higher protein (2RDA and 3RDA) lost a smaller proportion of fat-free mass and preserved more fat mass compared to the RDA group, indicating better preservation of muscle tissue.
  • Muscle protein synthesis in response to a protein-rich meal was similar during weight loss and maintenance for higher protein groups but was reduced during weight loss for the RDA group, suggesting that consuming more protein than the RDA can help prevent muscle loss during short-term dieting.]
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Top posts

Most liked on X and Bluesky
Dani Trainer
@Dani_trainer_ · X

Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y consumir el doble (1.6) y el triple (2.4) Consumiendo doble o triple de cantidad recomendada se pierde más grasa y se mantiene más músculo https://t.co/KQ0ObrwO0w https://t.co/BikG3qTqvO

Jun 6, 2023 · 29 likes · 7 shares · 18,544 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

In this week's video, @DrNadolsky goes over the basics on how to *GAIN* weight in a healthy way. No fads. No Sophie's choices. No gimmicks https://t.co/t4vXydXZm3

Apr 19, 2023 · 15 likes · 3 shares · 27,743 followers View post →
Brett Singer MS,RD,CSSD
@BSinger10 · X

Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: A randomized controlled trial https://t.co/9qGrupazPp

Oct 10, 2020 · 7 likes · 1 share · 2,812 followers View post →
Dr. Myohead
@DrMyohead · X

@ExphysPhD @NanciGuestRDPhD @mackinprof These are the closest to it that Im aware of: https://t.co/jgwlMr5QuN https://t.co/vTE4gdnj0G https://t.co/LFAXF8dmn2 https://t.co/MGidh6nusm

Apr 4, 2020 · 5 likes · 2,652 followers View post →
Amar
@Amarskmpni · X

@TheNutrivore Hi. Do you find any limitations in this? https://t.co/zvGo8ECTbU

Apr 7, 2023 · 5 likes · 1 share · 89 followers View post →
Evan Allen
@EAllen0417 · X

The second study did look at muscle synthesis and was a weight loss study. So neither study is looking at weight stable people who are training and simply maintaining body mass and trying to shift from fat mass to lean mass. https://t.co/4V2zROfqrQ

Feb 1, 2021 · 4 likes · 1 share · 2,796 followers View post →

All mentions

sadmiffy
@etherealnoah777 · X

@abeingbehaving @susicologa_ https://t.co/sZLmYBhfRx

Jul 23, 2025 · 1 followers View post →
каменяр
@PIBHE_BEPEC · X

@1msorussophobic @filatovadds З чого ти взяв, що катаболізм крайня міра? Організм розчепить мʼязи залюбки, якщо не буде стимулу і анаболізму. https://t.co/vIEfafvxld На тобі ще одне, тут конкретно, що вага пішла та ж сама, а При чому люди 25-28% RDA група більше мʼязів втратила.

Jul 8, 2025 · 9 followers View post →
ben_r_hoffman
@ben_r_hoffman · X

@RomeoStevens76 @AmandaAskell So I'm reverting to my prior estimate of outside-view 0.8 g / kg, but inside-view probably the body can't use more than it feels OK to eat. https://t.co/EUcaTLoWRr And if I fit a quadratic curve to the points measured in this study I get a similar result: https://t.co/dOtNtdI2PK

Feb 22, 2025 · 1,891 followers View post →
Ismael Galancho
@IsmaelGalancho · X

@jesuslimonjl 1.- https://t.co/CdtB4VLIZW 2.- https://t.co/7kZhTLklfl 3.- https://t.co/XzdycMXueS 4.- https://t.co/mOI7l4d1Ng 5.- https://t.co/KP6SpfoOls 6.- https://t.co/U6SICcyXbf 7.- https://t.co/XzTDZR2K7i

Nov 26, 2024 · 1 like · 40,814 followers View post →
まいち
@maiti_86 · X

@morningdietapp @digidigidaisy 60gが足りないといっているんですよ。 https://t.co/k1281Z0N2y

Nov 4, 2023 · 10,925 followers View post →
おじゃる丸～反グローバリズム
@jQfcNUsUIr5AMr8 · X

RT @maiti_86: @digidigidaisy PFCバランスを保ってカロリーを制限したらその前よりタンパク質の摂取量が減るでしょって話をしています。 過剰摂取であってもタンパク質は減らすべきではないということですよ。 減量中に60gを摂ればいいという話ですらない。…

Nov 3, 2023 · 1 share · 3,672 followers View post →
おじゃる丸～反グローバリズム
@jQfcNUsUIr5AMr8 · X

RT @maiti_86: @digidigidaisy https://t.co/k1281Z0N2y もう一度貼りますね。 私はそもそも推奨しているタンパク質量自体に問題があると考えている。 糖質過多の食事をしている時点でタンパク質量は足りていないんですよ。

Nov 3, 2023 · 2 shares · 3,672 followers View post →
yu-w
@yuw_75 · X

RT @maiti_86: @digidigidaisy https://t.co/k1281Z0N2y もう一度貼りますね。 私はそもそも推奨しているタンパク質量自体に問題があると考えている。 糖質過多の食事をしている時点でタンパク質量は足りていないんですよ。

Nov 3, 2023 · 2 shares · 515 followers View post →
まいち
@maiti_86 · X

@digidigidaisy https://t.co/k1281Z0N2y もう一度貼りますね。 私はそもそも推奨しているタンパク質量自体に問題があると考えている。 糖質過多の食事をしている時点でタンパク質量は足りていないんですよ。

Nov 3, 2023 · 2 likes · 2 shares · 10,925 followers View post →
まいち
@maiti_86 · X

@digidigidaisy PFCバランスを保ってカロリーを制限したらその前よりタンパク質の摂取量が減るでしょって話をしています。 過剰摂取であってもタンパク質は減らすべきではないということですよ。 減量中に60gを摂ればいいという話ですらない。 https://t.co/k1281Z0N2y

Nov 3, 2023 · 1 like · 1 share · 10,925 followers View post →
cyde
@TrueCyde · X

@njokicfanclub @NutritionMadeS3 https://t.co/iuEWCNhQcd

Jul 23, 2023 · 133 followers View post →
DIEGO PANDURO
@dediegoblogs · X

RT @Dani_trainer_: Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y cons…

Jun 6, 2023 · 7 shares · 1,583 followers View post →
Pedro
@Zirculovizioso · X

RT @Dani_trainer_: Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y cons…

Jun 6, 2023 · 7 shares · 249 followers View post →
Kory Guerrero
@koryguerrero7 · X

RT @Dani_trainer_: Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y cons…

Jun 6, 2023 · 7 shares · 225 followers View post →
cargonna
@cargonna · X

RT @Dani_trainer_: Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y cons…

Jun 6, 2023 · 7 shares · 39 followers View post →
Diego Sánchez
@Diegosb92 · X

RT @Dani_trainer_: Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y cons…

Jun 6, 2023 · 7 shares · 92 followers View post →
Dani Trainer
@Dani_trainer_ · X

Diferencias en pérdida de grasa tras consumir las recomendaciones oficiales de proteína (0.8 gramos x kg de peso) y consumir el doble (1.6) y el triple (2.4) Consumiendo doble o triple de cantidad recomendada se pierde más grasa y se mantiene más músculo https://t.co/KQ0ObrwO0w https://t.co/BikG3qTqvO

Jun 6, 2023 · 29 likes · 7 shares · 18,544 followers View post →
Dr. Spencer Nadolsky
@DrNadolsky · X

RT @NutritionMadeS3: In this week's video, @DrNadolsky goes over the basics on how to *GAIN* weight in a healthy way. No fads. No Sophie's…

Apr 20, 2023 · 3 shares · 58,860 followers View post →
Danijel
@MiocanDanijel · X

RT @NutritionMadeS3: In this week's video, @DrNadolsky goes over the basics on how to *GAIN* weight in a healthy way. No fads. No Sophie's…

Apr 20, 2023 · 3 shares · 1,116 followers View post →
Gabriel Stan
@StanGab79298982 · X

RT @NutritionMadeS3: In this week's video, @DrNadolsky goes over the basics on how to *GAIN* weight in a healthy way. No fads. No Sophie's…

Apr 19, 2023 · 3 shares · 216 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

In this week's video, @DrNadolsky goes over the basics on how to *GAIN* weight in a healthy way. No fads. No Sophie's choices. No gimmicks https://t.co/t4vXydXZm3

Apr 19, 2023 · 15 likes · 3 shares · 27,743 followers View post →
Alexander
@Alex_Hiden_ · X

RT @Amarskmpni: @TheNutrivore Hi. Do you find any limitations in this? https://t.co/zvGo8ECTbU

Apr 8, 2023 · 1 share · 2 followers View post →
Amar
@Amarskmpni · X

@TheNutrivore Hi. Do you find any limitations in this? https://t.co/zvGo8ECTbU

Apr 7, 2023 · 5 likes · 1 share · 89 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @FusionProgGuy: @Alan_Watson_ @jennyalaking @ScepticalDoctor @hubermanlab @davidasinclair @johnmcdougallmd @TheVeganRD @NutritionMadeS3…

Sep 27, 2022 · 1 share · 1,391 followers View post →
McOwl Who
@wubalubb · X

@mhd25112 @Veganella_ @_Ryan_Griggs @nutrition_facts @Mark_Sisson @consciousmuscle https://t.co/ICAztm2MQw

Sep 23, 2022 · 94 followers View post →
McOwl Who
@wubalubb · X

@Joduisms @mhd25112 @Veganella_ @_Ryan_Griggs @nutrition_facts @Mark_Sisson @consciousmuscle More protein. More muscle. Bro. https://t.co/ICAztm2f0Y

Sep 23, 2022 · 94 followers View post →
Robbie Puddick (MSc, RNutr)
@RPuddick · X

Consuming protein at or around 1.5g/kg/day helps to attenuate loss of fat-free mass during weight loss Works out at about 30-35g protein per meal (this is probably a good target for general health too)

Feb 4, 2022 · 134 followers View post →
Robbie Puddick (MSc, RNutr)
@RPuddick · X

@donlayman 100% ⬇️ https://t.co/6O3p6LJZ1I Add in weight training and you can probably attenuate all lean mass loss (and even see a gain)

Feb 2, 2022 · 134 followers View post →
Fusion Prog Guy @ fusionprogguy.bsky.social
@FusionProgGuy · X

@Alan_Watson_ @jennyalaking @ScepticalDoctor @hubermanlab @davidasinclair @johnmcdougallmd @TheVeganRD @NutritionMadeS3 @BioLayne @JeffNippard There's been a general recognition in the fitness community that the RDI is a relatively low target - eg for people with fat loss goals "..consuming dietary protein at levels exceeding the RDA may protect fat-free mass during short-term weight loss." https://t.co/4Jnl2EyebF https://t.co/hrqZbpx0v4

Dec 31, 2021 · 2 likes · 1 share · 1,589 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @Jacobiome: Is the RDA for protein (0.8g/kg/day) appropriate? Most likely not. To preserve muscle mass while undereating energy, an in…

Nov 2, 2021 · 1 share · 638 followers View post →
Jacob Guenther
@JacobAGuenther · X

Is the RDA for protein (0.8g/kg/day) appropriate? Most likely not. To preserve muscle mass while undereating energy, an intake of around 1.6g/kg/day yields significantly better results. However, from this study we don't know what the exact optimum is. https://t.co/8dhF1SBArp https://t.co/b8tSo6WYjX

Aug 1, 2021 · 2 likes · 1 share · 784 followers View post →
Dr. Myohead
@DrMyohead · X

@proftipper @MarkJHutson More studies: “Severe” https://t.co/gG38r2IItC 55% https://t.co/Tr067kGU1O Field study positive BODY nitrogen balance at 40%: https://t.co/N5ur7LemT5 Whole body at 40%: https://t.co/MGidh65T3M 40%: https://t.co/0KzCamgb0O Semi starvation: https://t.co/MC4n7dlQ4U

May 25, 2021 · 1 like · 2,652 followers View post →
Dr Shraboni Ghosal, PhD
@ShraboniGhosal · X

RT @EAllen0417: The second study did look at muscle synthesis and was a weight loss study. So neither study is looking at weight stable peo…

Feb 2, 2021 · 1 share · 1,927 followers View post →
Evan Allen
@EAllen0417 · X

The second study did look at muscle synthesis and was a weight loss study. So neither study is looking at weight stable people who are training and simply maintaining body mass and trying to shift from fat mass to lean mass. https://t.co/4V2zROfqrQ

Feb 1, 2021 · 4 likes · 1 share · 2,796 followers View post →
Fusion Prog Guy @ fusionprogguy.bsky.social
@FusionProgGuy · X

RT @TerryExSci: @ScepticalDoctor @FusionProgGuy @EntrepreneurFg https://t.co/KEc0F4GYUb I have a similar study that showed during energy d…

Jan 15, 2021 · 1 share · 1,589 followers View post →
Terry CB MSc
@TerryExSci · X

@ScepticalDoctor @FusionProgGuy @EntrepreneurFg https://t.co/KEc0F4GYUb I have a similar study that showed during energy deficit that 2x RDA and 3x RDA had a sparing effect on fat-free body mass and increase the amount of fat mass lost when compared to 0.8g RDA

Jan 15, 2021 · 2 likes · 1 share · 440 followers View post →
Shannon Fizer, M.Sc.
@shannon_fizer · X

RT @BSinger10: Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: A randomized controlled t…

Oct 11, 2020 · 1 share · 152 followers View post →
Brett Singer MS,RD,CSSD
@BSinger10 · X

Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: A randomized controlled trial https://t.co/9qGrupazPp

Oct 10, 2020 · 7 likes · 1 share · 2,812 followers View post →
أ.د.سها عبدالجواد-
@suhahashimm · X

هده دراسة توضح ان الناس اللي بتاخد ١،٦ جم بروتين لكل كجم من وزنهم يخسروا دهون اكتر من اللي يتناولوا ١،١ جم بروتين لكل كجم من وزنهم

Aug 23, 2020 · 3 likes · 24,438 followers View post →
Dr. Myohead
@DrMyohead · X

@ExphysPhD @NanciGuestRDPhD @mackinprof These are the closest to it that Im aware of: https://t.co/jgwlMr5QuN https://t.co/vTE4gdnj0G https://t.co/LFAXF8dmn2 https://t.co/MGidh6nusm

Apr 4, 2020 · 5 likes · 2,652 followers View post →