Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents?

Abstract in brief

• This study explores the potential link between oxidized linoleic acid metabolites (OXFAs) and the development of fatty liver disease and type 2 diabetes in obese adolescents, showing certain OXFAs are associated with liver injury markers and insulin secretion.
• The research finds that adolescents with fatty liver (NAFLD) and higher OXFAs levels, especially those with type 2 diabetes, may have a connection mediated by genetic factors like the PNPLA3 gene variant, suggesting OXFAs could play a role in disease progression.
• The findings propose that targeting OXFAs could be a new way to treat or prevent early-onset fatty liver disease and diabetes in obese teens, indicating potential for novel therapeutic approaches.