Nutr Cancer February 2014 PMID 23859042

Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells.

Dagmar Richter, Sibylle Abarzua, Mareike Chrobak, Thomas Vrekoussis, Tobias Weissenbacher, Christina Kuhn, Sandra Schulze, Markus S Kupka, Klaus Friese, Volker Briese, Birgit Piechulla, Antonis Makrigiannakis, Udo Jeschke, Darius Dian

Mentions

20
Peak: 1 in Feb 2023
across 5 sources since Feb 2023

Extended reach

4,486,131
potential audience

Total likes

41,396

Video views

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Mentions per month

Feb 2023 – Oct 2023

Where it's discussed

  • News11 articles
  • Facebook3 posts
  • Blogs3 articles
  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions highlight specific findings like PSE's ability to modulate estrogen and progesterone receptors, with phrases such as 'potential breakthrough' and 'promising natural therapy' showing enthusiasm. The tone remains cautiously optimistic, reflecting both curiosity and acknowledgment of ongoing research needs.

AgreementModerate agreement

Most discussions acknowledge the potential significance of pumpkin seed extracts in influencing hormone-related pathways in cancer cells, indicating moderate agreement with the study’s implications.

InterestModerate interest

Posts show a general curiosity about natural compounds and their role in cancer treatment, reflecting a mild level of interest.

EngagementModerate engagement

Participants reference specific findings, such as changes in hormone receptor levels, demonstrating a moderate level of detailed engagement.

ImpactModerate impact

The discussions suggest the possibility of future therapeutic applications, indicating perceived moderate impact on cancer research and treatment strategies.

Abstract in brief

  • The study explored how pumpkin seed extract (PSE), which contains lignans and flavones, affects hormone production and receptor expression in breast cancer and placental tumor cells.
  • PSE increased estradiol production in these cells and caused a decrease in estrogen receptor (ER) levels while increasing progesterone receptor (PR) levels in MCF7 cells.
  • These findings suggest that pumpkin seed lignans could potentially play a role in preventing or treating hormone-dependent cancers, but more animal studies are needed to confirm this.]

Top posts

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Greta Compton Dip DH RCSEd aka Gretsky
@Gretsky_Compton · X

Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells - PubMed https://t.co/WRKWJ9AgOX

Oct 18, 2023 · 899 followers View post →

All mentions

Greta Compton Dip DH RCSEd aka Gretsky
@Gretsky_Compton · X

Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells - PubMed https://t.co/WRKWJ9AgOX

Oct 18, 2023 · 899 followers View post →