Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers.

Abstract in brief

• The study examined how around-the-clock oral THC affects sleep in male daily cannabis smokers and found that higher plasma THC levels were linked to quicker sleep onset and increased daytime sleep, but overall nocturnal sleep duration slightly decreased over time.
• Despite animal studies and clinical use suggesting THC promotes sleep, human lab studies have shown inconsistent results; this research indicates that tolerance to THC's sedative effects may develop with chronic high-dose use.
• The findings have potential implications for patients using oral THC regularly for medicinal reasons, such as managing cannabis dependence, as somnolence may diminish with continued use.]