PubHawk
Pharmacol Ther February 2014 PMID 24080471

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.

Gordon F Rushworth, Ian L Megson

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Mentions

9
Peak: 1 in May 2021
across 4 sources since May 2021

Extended reach

103,739
potential audience

Total likes

5,326

Video views

102,696

Mentions per month

May 2021 – Nov 2024

Where it's discussed

  • News3 articles
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  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions reflect awareness of NAC's therapeutic potential, with users referencing its role as a precursor to glutathione and mentioning regulatory challenges, such as the FDA's stance, using words like 'works' and 'butt hurt,' which convey both recognition of its efficacy and frustration with regulatory barriers. These tone choices highlight a mix of support and skepticism regarding NAC's status and recognition in medicine.

AgreementModerate agreement

The discussion suggests agreement on NAC's effectiveness and its role as a precursor to the key antioxidant glutathione, indicating a moderate positive stance.

InterestModerate interest

Participants show some interest in regulatory issues and the scientific background, but the engagement remains relatively superficial.

EngagementNeutral engagement

The comments briefly touch on the controversy and the nature of NAC's therapeutic use but do not delve deeply into scientific details or implications.

ImpactModerate impact

The conversation hints at broader discussions about pharmaceutical and regulatory influences, which could influence perceptions and policies, reflecting a moderate impact.

Abstract in brief

  • N-Acetylcysteine (NAC) has primarily been used to treat acetaminophen overdose by serving as a precursor for glutathione (GSH) synthesis in the liver, especially when GSH levels are depleted.
  • Beyond its initial use, NAC is also used to alleviate symptoms of cystic fibrosis by disrupting mucus through cysteine-mediated interactions, and recent studies have explored its antioxidant potential in conditions like contrast-induced nephropathy and thrombosis with mixed results.
  • The review emphasizes that NAC’s antioxidant effects depend on its conversion to GSH, not as a direct antioxidant, and its effectiveness relies on the presence of the cellular pathways for GSH synthesis, making it more of a targeted replenisher than a powerful antioxidant on its own.]
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Top posts

Most liked on X and Bluesky
Dr .JUAN RAUL GIL FRÍAS unam
@GILFRIAS · X

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione … https://t.co/XMt3oOXcfB

Jul 25, 2023 · 774 followers View post →
Tocqueville
@Tocqueville_eye · X

@mcuban In many cases yes. But the FDA is butt hurt over the supplement, NAC, because it works. A precursor to the 'master' antioxidant glutathione. Now they want to argue that it was studied as a drug first $$$. https://t.co/Iiq7KYURts

May 26, 2021 · 269 followers View post →

All mentions

Dr .JUAN RAUL GIL FRÍAS unam
@GILFRIAS · X

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione … https://t.co/XMt3oOXcfB

Jul 25, 2023 · 774 followers View post →
Tocqueville
@Tocqueville_eye · X

@mcuban In many cases yes. But the FDA is butt hurt over the supplement, NAC, because it works. A precursor to the 'master' antioxidant glutathione. Now they want to argue that it was studied as a drug first $$$. https://t.co/Iiq7KYURts

May 26, 2021 · 269 followers View post →