Diabetologia January 2014 PMID 24121625

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.

Richard A Oram, Angus G Jones, Rachel E J Besser, Bridget A Knight, Beverley M Shields, Richard J Brown, Andrew T Hattersley, Timothy J McDonald

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Peak: 2 in Aug 2020

across 4 sources since Aug 2020

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What people are saying

The overall digital discussions display a moderate interest and agreement with the article, with posters referencing specific insulin levels and past studies, such as mentions of beta cell activity after 20 years and normal value ranges, which shows a focus on scientific details and implications for diabetes management. The tone is primarily inquisitive and analytical, contributing to a nuanced appreciation of the research findings.

AgreementModerate agreement

Most discussions acknowledge the article's findings about residual insulin production in long-term type 1 diabetes, reflecting moderate support.

InterestModerate interest

Participants show some curiosity, referencing further studies and details about beta cell activity and insulin levels.

EngagementModerate engagement

Comments engage with the topic by recalling other research and sharing personal insights, indicating moderate involvement.

ImpactNeutral impact

The discussions do not suggest a major shift in understanding but highlight relevance to ongoing research and treatment perspectives.

Abstract in brief

Most patients with longstanding type 1 diabetes still produce very low levels of insulin, as detected by ultrasensitive tests, and these levels often increase after meals.
Despite the progressive loss of insulin over time, a significant number of patients (about 73%) still have detectable C-peptide, indicating some remaining beta cell activity.
The findings suggest that these residual beta cells may either be escaping immune destruction or regenerating, which could have implications for future treatments aiming to preserve or restore insulin production.]

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All mentions

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Stefan Sarin

@Stefan999 · X

@Mike24816 @NTSTranslation @Michael_INTJ @drtroystapleton @idlake @KenDBerryMD @drandyphung @Type1Berger Yes, there is a decline in working beta cells over time, see https://t.co/9bBoolpwoa, quick google says normal values is 0.5-2.7 ng/mL => 167-900 pmol/l, so <20 years, possible and normal means high carb. https://t.co/GmrIy4hwMu

Oct 16, 2020 · 63 followers View post →

Andrew Berger

@Type1Berger · X

RT @Stefan999: @Type1Berger I think I read a more conclusive study many years ago, but this says at least some insulin production after 20…

Aug 25, 2020 · 1 share · 1,286 followers View post →