April 2014 PMID 24245565

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.

David E Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon, James F Nelson, Scott Pletcher, James W Simpkins, Daniel Smith, J Erby Wilkinson

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Mentions

19
Peak: 2 in Sep 2021
across 5 sources since Sep 2020

Extended reach

413,124
potential audience

Total likes

82

Video views

2,271

Mentions per month

Sep 2020 – Sep 2025

Where it's discussed

  • X / Twitter8 posts
  • Blogs4 articles
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The comments reflect a genuine interest in the sex-specific effects of compounds like acarbose and estradiol, with mentions of hormones, hormone replacement therapy, and causes of mortality, such as cardiovascular disease. The tone varies from cautious acknowledgment to curiosity about broader implications, illustrating moderate engagement and perceived impact in aging research.

AgreementModerate agreement

Most discussions recognize the validity and significance of the research findings, with some referencing the specific effects on male vs. female lifespan.

InterestModerate interest

Posts show moderate curiosity by mentioning broader impacts like hormones and aging, but lack in-depth analysis or critique.

EngagementModerate engagement

Participants engage by linking the findings to related topics such as hormone therapy and causes of death, indicating active interest.

ImpactModerate impact

The discussions suggest the research could influence future aging studies and health interventions, but it's not portrayed as a revolutionary breakthrough.

Abstract in brief

  • Several agents, including acarbose, 17-estradiol, and nordihydroguaiaretic acid (NDGA), were studied to see their effects on the lifespan of genetically diverse mice, with varying results based on sex and site of testing.
  • Acarbose significantly extended male lifespan by 22% and females by 5%, with a stronger effect on maximum lifespan in both sexes; 17-estradiol mainly extended male lifespan but did not affect females or maximum lifespan, and its effects varied by testing site; NDGA increased male lifespan notably but did not benefit females, indicating sex-specific responses.
  • Methylene blue showed minimal impact on median lifespan but modestly increased female maximum lifespan; overall, these findings suggest potential for drugs to influence aging differently in males and females, aiding in understanding aging processes and sex differences.

Top posts

Most liked on X and Bluesky
Lamming Lab
@LammingLab · X

@whsource @JimJohnsonSci With respect to @JimJohnsonSci this goes against both conventional wisdom and detailed cause of death analysis by the NIA Interventions Testing Program - e.g. looks like less than 5% of deaths are from CVD linked issues in this study (Table S1) https://t.co/SzXp18boIh

Sep 12, 2020 · 4 likes · 5,852 followers View post →
Agingdoc
@agingdoc1 · X

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/L8NUdRKo3F

Mar 7, 2022 · 2 likes · 42,950 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@DonColaFitness @Blagosklonny Thanks - 17 - alpha - estradiol https://t.co/OpIl3OYxlf

Sep 21, 2021 · 1 like · 1 share · 295,789 followers View post →
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

@john_r365 @thereal_willsav There are three studies: https://t.co/o4KqAjgavc https://t.co/1VuUBWgP0t

Jun 29, 2021 · 1 like · 22,266 followers View post →
Orlando_uy
@Orlando_uy · X

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/ot0egUNCBL

Jul 6, 2021 · 1 like · 696 followers View post →
Agingdoc
@agingdoc1 · X

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2014) https://t.co/xy5n2u5XHE @AgingCell #ITP

Mar 22, 2022 · 42,950 followers View post →

All mentions

Flower_Girl_2115
@FlowerGirl_2115 · X

@LaurieGreen36 Here's Interventions Testing Program studies: https://t.co/N0MbJHLuZR https://t.co/Jo5hCTibME

Feb 9, 2024 · 339 followers View post →
Agingdoc
@agingdoc1 · X

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2014) https://t.co/xy5n2u5XHE @AgingCell #ITP

Mar 22, 2022 · 42,950 followers View post →
Agingdoc
@agingdoc1 · X

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/L8NUdRKo3F

Mar 7, 2022 · 2 likes · 42,950 followers View post →
vintologi2
@vintologi2 · X

@joneslinda @betsvigi9 @mrravenclawed This mice study incidate that it's about hormones which are changed by HRT https://t.co/VSPqlGbJsG

Sep 25, 2021 · 10 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@DonColaFitness @Blagosklonny Thanks - 17 - alpha - estradiol https://t.co/OpIl3OYxlf

Sep 21, 2021 · 1 like · 1 share · 295,789 followers View post →
Orlando_uy
@Orlando_uy · X

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/ot0egUNCBL

Jul 6, 2021 · 1 like · 696 followers View post →
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

@john_r365 @thereal_willsav There are three studies: https://t.co/o4KqAjgavc https://t.co/1VuUBWgP0t

Jun 29, 2021 · 1 like · 22,266 followers View post →
Lamming Lab
@LammingLab · X

@whsource @JimJohnsonSci With respect to @JimJohnsonSci this goes against both conventional wisdom and detailed cause of death analysis by the NIA Interventions Testing Program - e.g. looks like less than 5% of deaths are from CVD linked issues in this study (Table S1) https://t.co/SzXp18boIh

Sep 12, 2020 · 4 likes · 5,852 followers View post →