@whsource @JimJohnsonSci With respect to @JimJohnsonSci this goes against both conventional wisdom and detailed cause of death analysis by the NIA Interventions Testing Program - e.g. looks like less than 5% of deaths are from CVD linked issues in this study (Table S1) https://t.co/SzXp18boIh
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.
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Sep 2020 – Sep 2025Where it's discussed
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X / Twitter8 posts
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Blogs4 articles
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News3 articles
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YouTube2 videos
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AI synopsis
What people are saying
The comments reflect a genuine interest in the sex-specific effects of compounds like acarbose and estradiol, with mentions of hormones, hormone replacement therapy, and causes of mortality, such as cardiovascular disease. The tone varies from cautious acknowledgment to curiosity about broader implications, illustrating moderate engagement and perceived impact in aging research.
Most discussions recognize the validity and significance of the research findings, with some referencing the specific effects on male vs. female lifespan.
Posts show moderate curiosity by mentioning broader impacts like hormones and aging, but lack in-depth analysis or critique.
Participants engage by linking the findings to related topics such as hormone therapy and causes of death, indicating active interest.
The discussions suggest the research could influence future aging studies and health interventions, but it's not portrayed as a revolutionary breakthrough.
Abstract in brief
- Several agents, including acarbose, 17-estradiol, and nordihydroguaiaretic acid (NDGA), were studied to see their effects on the lifespan of genetically diverse mice, with varying results based on sex and site of testing.
- Acarbose significantly extended male lifespan by 22% and females by 5%, with a stronger effect on maximum lifespan in both sexes; 17-estradiol mainly extended male lifespan but did not affect females or maximum lifespan, and its effects varied by testing site; NDGA increased male lifespan notably but did not benefit females, indicating sex-specific responses.
- Methylene blue showed minimal impact on median lifespan but modestly increased female maximum lifespan; overall, these findings suggest potential for drugs to influence aging differently in males and females, aiding in understanding aging processes and sex differences.
Top posts
Most liked on X and BlueskyAcarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/L8NUdRKo3F
@DonColaFitness @Blagosklonny Thanks - 17 - alpha - estradiol https://t.co/OpIl3OYxlf
@john_r365 @thereal_willsav There are three studies: https://t.co/o4KqAjgavc https://t.co/1VuUBWgP0t
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/ot0egUNCBL
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2014) https://t.co/xy5n2u5XHE @AgingCell #ITP
All mentions
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@LaurieGreen36 Here's Interventions Testing Program studies: https://t.co/N0MbJHLuZR https://t.co/Jo5hCTibME
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2014) https://t.co/xy5n2u5XHE @AgingCell #ITP
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/L8NUdRKo3F
@joneslinda @betsvigi9 @mrravenclawed This mice study incidate that it's about hormones which are changed by HRT https://t.co/VSPqlGbJsG
@DonColaFitness @Blagosklonny Thanks - 17 - alpha - estradiol https://t.co/OpIl3OYxlf
Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males https://t.co/ot0egUNCBL
@john_r365 @thereal_willsav There are three studies: https://t.co/o4KqAjgavc https://t.co/1VuUBWgP0t
@whsource @JimJohnsonSci With respect to @JimJohnsonSci this goes against both conventional wisdom and detailed cause of death analysis by the NIA Interventions Testing Program - e.g. looks like less than 5% of deaths are from CVD linked issues in this study (Table S1) https://t.co/SzXp18boIh
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